{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T19:31:23Z","timestamp":1777923083023,"version":"3.51.4"},"reference-count":39,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Microbial Drug Resistance"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:sec>\n                    <jats:title>Aims:<\/jats:title>\n                    <jats:p>\n                      The fluid of\n                      <jats:italic toggle=\"yes\">Nepenthes gracilis<\/jats:italic>\n                      harbors diverse bacterial taxa that could serve as a gene pool for the discovery of the new genre of antimicrobial agents against multidrug-resistant\n                      <jats:italic toggle=\"yes\">Klebsiella pneumoniae<\/jats:italic>\n                      . The aim of this study was to explore the presence of antibacterial genes in the fluids of\n                      <jats:italic toggle=\"yes\">N. gracilis<\/jats:italic>\n                      growing in the wild.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      Using functional metagenomic approach, fosmid clones were isolated and screened for antibacterial activity against three strains of\n                      <jats:italic toggle=\"yes\">K. pneumoniae<\/jats:italic>\n                      . A clone that exhibited the most potent antibacterial activity was sent for sequencing to identify the genes responsible for the observed activity. The secondary metabolites secreted by the selected clone was sequentially extracted using hexane, chloroform, and ethyl acetate. The chemical profiles of a clone (C6) hexane extract were determined by gas chromatography\/mass spectrometry (GC-MS).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Fosmid clone C6 from the fluid of pitcher plant that exhibited antibacterial activity against three strains of\n                      <jats:italic toggle=\"yes\">K. pneumoniae<\/jats:italic>\n                      was isolated using functional metagenome approach. A majority of the open reading frames detected from C6 were affiliated with the largely understudied\n                      <jats:italic toggle=\"yes\">Acidocella<\/jats:italic>\n                      genus. Among them, the gene that encodes for coproporphyrinogen III oxidase in the heme biosynthesis pathway could be involved in the observed antibacterial activity. Based on the GC-MS analysis, the identities of the putative bioactive compounds were 2,5-di-\n                      <jats:italic toggle=\"yes\">tert<\/jats:italic>\n                      -butylphenol and 1-ethyl-2-methyl cyclododecane.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>\n                      The gene that encodes for coproporphyrinogen III oxidase in the heme biosynthesis pathway as well as the secondary metabolites, namely 2,5-di-\n                      <jats:italic toggle=\"yes\">tert<\/jats:italic>\n                      -butylphenol and 1-ethyl-2-methyl cyclododecane could be the potential antibacterial molecules responsible for the antibacterial activity of C6.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/mdr.2020.0311","type":"journal-article","created":{"date-parts":[[2020,12,16]],"date-time":"2020-12-16T12:55:30Z","timestamp":1608123330000},"page":"1018-1028","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["The Antibacterial Agent Identified from\n                    <i>Acidocella<\/i>\n                    spp. in the Fluid of\n                    <i>Nepenthes gracilis<\/i>\n                    Against Multidrug-Resistant\n                    <i>Klebsiella pneumoniae<\/i>\n                    : A Functional Metagenomic Approach"],"prefix":"10.1177","volume":"27","author":[{"given":"Elaine Wan Ling","family":"Chan","sequence":"first","affiliation":[{"name":"Institute for Research, Development and Innovation, International Medical University, Kuala Lumpur, Malaysia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mei Yu","family":"Chin","sequence":"additional","affiliation":[{"name":"School of Pharmacy, International Medical University, Kuala Lumpur, Malaysia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi Hui","family":"Low","sequence":"additional","affiliation":[{"name":"School of Pharmacy, International Medical University, Kuala Lumpur, Malaysia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui Yin","family":"Tan","sequence":"additional","affiliation":[{"name":"School of Pharmacy, International Medical University, Kuala Lumpur, Malaysia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi Sing","family":"Ooi","sequence":"additional","affiliation":[{"name":"School of Pharmacy, International Medical University, Kuala Lumpur, Malaysia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chun Wie","family":"Chong","sequence":"additional","affiliation":[{"name":"Institute for Research, Development and Innovation, International Medical University, Kuala Lumpur, Malaysia."},{"name":"School of Pharmacy, Monash University Malaysia, Bandar Sunway, Malaysia."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2021,8,12]]},"reference":[{"key":"e_1_3_4_2_2","first-page":"277","article-title":"The antibiotic resistance crisis: part 1: causes and threats","volume":"40","author":"Ventola, C.L","year":"2015","unstructured":"Ventola, C.L. 2015. 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