{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T23:11:33Z","timestamp":1787008293763,"version":"build-2736575974"},"reference-count":15,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Microbial Drug Resistance"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:p>\n                    <jats:italic toggle=\"yes\">Staphylococcus aureus<\/jats:italic>\n                    bacteremia is a life-threatening condition associated with a substantial financial burden on the health care system. The use of the GeneXpert\n                    <jats:sup>\u00ae<\/jats:sup>\n                    methicillin-resistant\n                    <jats:italic toggle=\"yes\">S. aureus<\/jats:italic>\n                    (MRSA)\/\n                    <jats:italic toggle=\"yes\">S. aureus<\/jats:italic>\n                    blood culture (BC) test for the identification of\n                    <jats:italic toggle=\"yes\">S. aureus<\/jats:italic>\n                    may influence antibiotic stewardship and clinical outcomes. This study assessed the clinical and financial impact of utilizing GeneXpert MRSA\/SA in combination with criterion-based testing. The outcomes between October 1, 2018, and June 30, 2019, were evaluated in 65 adult patients who had positive BCs with Gram-positive cocci in clusters. GeneXpert MRSA\/SA significantly shortened the time to optimal antimicrobial therapy by 1.7 days (2.5 vs. 44\u2009hr,\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009&lt;\u20090.0001). The cost saved because of interventions based on GeneXpert testing results was $4,121. GeneXpert testing has shortened the time to optimal therapy and positively impacted cost, although it had no significant effect on length of hospital stay and mortality rate.\n                  <\/jats:p>","DOI":"10.1089\/mdr.2020.0347","type":"journal-article","created":{"date-parts":[[2021,2,5]],"date-time":"2021-02-05T11:36:55Z","timestamp":1612525015000},"page":"1037-1043","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":7,"title":["Impact of Rapid Identification of\n                    <i>Staphylococcus<\/i>\n                    Species in Positive Blood Culture Using GeneXpert Methicillin-Resistant\n                    <i>Staphylococcus aureus<\/i>\n                    \/\n                    <i>Staphylococcus aureus<\/i>\n                    Blood Culture Assay Combined with Antibiotic Stewardship"],"prefix":"10.1177","volume":"27","author":[{"given":"Hajar","family":"AlQahtani","sequence":"first","affiliation":[{"name":"Department of Pharmacy Services, King Abdul-Aziz Medical City, Ministry of National Guard, Health Affairs, Riyadh, Saudi Arabia."},{"name":"Department of Infectious Diseases, Piedmont Columbus Regional Healthcare System, Columbus, Georgia, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fulwah Yahya","family":"Alqahtani","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fadilah Sfouq","family":"Aleanizy","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saeed","family":"Baloch","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Piedmont Columbus Regional Healthcare System, Columbus, Georgia, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deanne","family":"Tabb","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Piedmont Columbus Regional Healthcare System, Columbus, Georgia, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2021,8,12]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.diagmicrobio.2004.05.003"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.165.15.1756"},{"key":"e_1_3_3_4_2","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1086\/660096","article-title":"Clinical impact of blood cultures contaminated with coagulase-negative staphylococci at an academic medical center","volume":"32","author":"van der Heijden Y.F.","year":"2011","unstructured":"van der Heijden Y.F., , Miller G., , Wright P.W, , Shepherd B.E, , Daniels T.L, , and Talbot T.R.. 2011. Clinical impact of blood cultures contaminated with coagulase-negative staphylococci at an academic medical center. Infect. Control Hosp. Epidemiol. 32:623\u2013625.","journal-title":"Infect. Control Hosp. Epidemiol"},{"issue":"2","key":"e_1_3_3_5_2","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1099\/jmm.0.050385-0","article-title":"Rapid identification of Gram-positive pathogens and their resistance genes from positive blood culture broth using a multiplex tandem RT-PCR assay","volume":"62","author":"Hazelton B.J.","year":"2013","unstructured":"Hazelton B.J., , Thomas L.C, , Unver T., , and Iredell J.R.. 2013. Rapid identification of Gram-positive pathogens and their resistance genes from positive blood culture broth using a multiplex tandem RT-PCR assay. J. Med. Microbiol. 62(Pt 2):223\u2013231.","journal-title":"J. Med. Microbiol"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-006-0096-0"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00700-07"},{"key":"e_1_3_3_8_2","first-page":"275","article-title":"Antibiotic discovery: state of the state","volume":"70","author":"Shlaes D.M.","year":"2004","unstructured":"Shlaes D.M., , Projan S.J, , and Edwards J.EJr. 2004. Antibiotic discovery: state of the state. ASM News, 70:275\u2013281.","journal-title":"ASM News"},{"key":"e_1_3_3_9_2","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1002\/phar.1557","article-title":"Outcomes of rapid identification for gram-positive bacteremia in combination with antibiotic stewardship at a community-based hospital system","volume":"35","author":"Box M.J.","year":"2015","unstructured":"Box M.J., , Sullivan E.L, , Ortwine K.N, , Parmenter M.A, , Quigley M.M, , Aguilar-Higgins L.M, , MacIntosh C.L, , Goerke K.F, , and Lim R.A.. 2015. Outcomes of rapid identification for gram-positive bacteremia in combination with antibiotic stewardship at a community-based hospital system. Pharmacotherapy, 35:269\u2013276.","journal-title":"Pharmacotherapy"},{"key":"e_1_3_3_10_2","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1093\/cid\/cix306","article-title":"Reducing contamination of blood cultures: consider costs and clinical benefits","volume":"65","author":"McAdam A.J.","year":"2017","unstructured":"McAdam A.J. 2017. Reducing contamination of blood cultures: consider costs and clinical benefits. Clin. Infect. Dis. 65:206\u2013207.","journal-title":"Clin. Infect. Dis"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.02245-16"},{"key":"e_1_3_3_12_2","unstructured":"Cepheid. 2008. Xpert\u2122 MRSA\/SA blood culture: package insert. Cepheid. 300-7188."},{"key":"e_1_3_3_13_2","doi-asserted-by":"crossref","first-page":"e0161684","DOI":"10.1371\/journal.pone.0161684","article-title":"Rapid diagnosis of staphylococcal catheter-related bacteraemia in direct blood samples by real-time PCR","volume":"11","author":"Zboromyrska Y.","year":"2016","unstructured":"Zboromyrska Y., , De la Calle C., , Soto M., , Sampietro-Colom L., , Soriano A., , Alvarez-Martinez M.J, , Almela M., , Marco F., , Arjona R., , Cobos-Trigueros N., , Morata L., , Mensa J., , Martinez J.A, , Mira A., , and Vila J.. 2016. Rapid diagnosis of staphylococcal catheter-related bacteraemia in direct blood samples by real-time PCR. PLoS One, 11:e0161684.","journal-title":"PLoS One"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1309\/AJCP07UGYOKBVVNC"},{"key":"e_1_3_3_15_2","first-page":"1074","volume":"51","author":"Bauer K.A.","year":"2010","unstructured":"Bauer K.A., , West J.E, , Balada-Llasat J.M, , Pancholi P., , Stevenson K.B, , and Goff D.A.. 2010. An antimicrobial stewardship program's impact with rapid polymerase chain reaction methicillin-resistant Staphylococcus aureus\/S. aureus blood culture test in patients with S. aureus bacteremia. Clin. Infect. Dis. 51:1074\u20131080.","journal-title":"An antimicrobial stewardship program's impact with rapid polymerase chain reaction methicillin-resistant Staphylococcus aureus\/S. aureus blood culture test in patients with S. aureus bacteremia. Clin. Infect. 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