{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T13:00:26Z","timestamp":1790686826541,"version":"4.1.0"},"reference-count":36,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Microbial Drug Resistance"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:p>\n                    Carbapenemase-producing\n                    <jats:italic toggle=\"yes\">Pseudomonas aeruginosa<\/jats:italic>\n                    (CPPA) is a threat to public health. This study aimed to describe the first emergence and molecular characterization of NDM-1-producing\n                    <jats:italic toggle=\"yes\">P. aeruginosa<\/jats:italic>\n                    in South Korea. A total of 183 carbapenem-resistant\n                    <jats:italic toggle=\"yes\">P. aeruginosa<\/jats:italic>\n                    (CRPA) isolates were recovered from patients at a university hospital in Seoul, South Korea. The antimicrobial resistance genes and their genetic environments were determined through molecular sequencing. Antimicrobial susceptibility testing was performed using the VITEK 2 system and broth microdilution method. Genetic relatedness was assessed using multilocus sequence typing and pulsed-field gel electrophoresis. Whole genome sequencing (WGS) was carried out to analyze the entire genome of a CPPA isolated from the index patient; the first identified infected patient. All 16 CPPA isolates from the 183 CRPA carried the\n                    <jats:italic toggle=\"yes\">bla<\/jats:italic>\n                    <jats:sub>NDM-1<\/jats:sub>\n                    gene and exhibited a high level of resistance to \u03b2-lactams, aminoglycosides, and ciprofloxacin. Fifteen of the 16 isolates were recovered from urine samples. They were attributed to ST773 and showed high clonal similarity (&gt;86%). Post-WGS analysis revealed that the\n                    <jats:italic toggle=\"yes\">bla<\/jats:italic>\n                    <jats:sub>NDM-1<\/jats:sub>\n                    gene and the 16S rRNA methyltransferase gene\n                    <jats:italic toggle=\"yes\">rmtB4<\/jats:italic>\n                    were located in the integrative and conjugative element (ICE) on the chromosome. This ICE\n                    <jats:italic toggle=\"yes\">6660-like<\/jats:italic>\n                    region was very similar to the ICE\n                    <jats:italic toggle=\"yes\">6660<\/jats:italic>\n                    region carrying the\n                    <jats:italic toggle=\"yes\">bla<\/jats:italic>\n                    <jats:sub>NDM-1<\/jats:sub>\n                    gene and the 16S rRNA methyltransferase gene\n                    <jats:italic toggle=\"yes\">rmtD3<\/jats:italic>\n                    in a previously described\n                    <jats:italic toggle=\"yes\">P. aeruginosa<\/jats:italic>\n                    strain. This study described the first emergence and clonal spread of the NDM-1-producing\n                    <jats:italic toggle=\"yes\">P. aeruginosa<\/jats:italic>\n                    ST773 isolates possessing\n                    <jats:italic toggle=\"yes\">rmtB4<\/jats:italic>\n                    , at a university hospital in South Korea, suggesting that continuous surveillance is necessary to prevent infection and transmission of these CRPAs, which can endanger public health.\n                  <\/jats:p>","DOI":"10.1089\/mdr.2020.0374","type":"journal-article","created":{"date-parts":[[2020,12,17]],"date-time":"2020-12-17T14:58:04Z","timestamp":1608217084000},"page":"1063-1070","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":26,"title":["Molecular Characterization of the First Emerged NDM-1-Producing\n                    <i>Pseudomonas aeruginosa<\/i>\n                    Isolates in South Korea"],"prefix":"10.1177","volume":"27","author":[{"given":"Jun Sung","family":"Hong","sequence":"first","affiliation":[{"name":"Department of Laboratory Medicine and Research, Institute of Bacterial Resistance, Yonsei University College of Medicine, Seoul, South Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wonkeun","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Hallym University College of Medicine, Chuncheon, South Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min-Jeong","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Hallym University College of Medicine, Chuncheon, South Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seri","family":"Jeong","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Hallym University College of Medicine, Chuncheon, South Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nuri","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Hallym University College of Medicine, Chuncheon, South Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seok Hoon","family":"Jeong","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Research, Institute of Bacterial Resistance, Yonsei University College of Medicine, Seoul, South Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2021,8,12]]},"reference":[{"key":"e_1_3_3_2_2","first-page":"e01243","article-title":"Carbapenem-resistant Pseudomonas aeruginosa bacteremia: risk factors for mortality and microbiologic treatment failure","volume":"61","author":"Buehrle D.J.","year":"2016","unstructured":"Buehrle D.J., , Shields R.K, , Clarke L.G, , Potoski B.A, , Clancy C.J, , and Nguyen M.H.. 2016. 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Epidemiology and characteristics of metallo-\u03b2-lactamase-producing Pseudomonas aeruginosa. Infect. Chemother. 47:81\u201397.","journal-title":"Epidemiology and characteristics of metallo-\u03b2-lactamase-producing Pseudomonas aeruginosa. Infect. Chemother"},{"key":"e_1_3_3_5_2","doi-asserted-by":"crossref","first-page":"7216","DOI":"10.1128\/AAC.01601-16","article-title":"Clonal dissemination of Pseudomonas aeruginosa sequence type 235 isolates carrying bla\n                  IMP-6 and Emergence of bla\n                  GES-24 and bla\n                  IMP-10 on novel genomic islands PAGI-15 and -16 in South Korea","volume":"60","author":"Hong J.S.","year":"2016","unstructured":"Hong J.S., , Yoon E.J, , Lee H., , Jeong S.H, , and Lee K.. 2016. Clonal dissemination of Pseudomonas aeruginosa sequence type 235 isolates carrying blaIMP-6 and Emergence of blaGES-24 and blaIMP-10 on novel genomic islands PAGI-15 and -16 in South Korea. Antimicrob. Agents Chemother. 60:7216\u20137223.","journal-title":"Antimicrob. Agents Chemother"},{"key":"e_1_3_3_6_2","doi-asserted-by":"crossref","first-page":"3929","DOI":"10.1128\/AAC.00226-11","article-title":"Emergence of NDM-1 metallo-\u03b2-lactamase in Pseudomonas aeruginosa clinical isolates from Serbia","volume":"55","author":"Jovcic B.","year":"2011","unstructured":"Jovcic B., , Lepsanovic Z., , Suljagic V., , Rackov G., , Begovic J., , Topisirovic L., , and Kojic M.. 2011. Emergence of NDM-1 metallo-\u03b2-lactamase in Pseudomonas aeruginosa clinical isolates from Serbia. Antimicrob. Agents Chemother. 55:3929\u20133931.","journal-title":"Antimicrob. 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