{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T15:35:04Z","timestamp":1789227304802,"version":"build-2803163510"},"reference-count":44,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Microbial Drug Resistance"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:p>\n                    Trimethoprim-\/sulfamethoxazole-resistant small colony variants (SCVs) of\n                    <jats:italic toggle=\"yes\">Staphylococcus aureus<\/jats:italic>\n                    , which are selected by use of trimethoprim\/sulfamethoxazole, are involved in intractable biofilm-forming infection. This study aimed to determine the biofilm formation ability in trimethoprim-\/sulfamethoxazole-resistant SCVs of\n                    <jats:italic toggle=\"yes\">S. aureus<\/jats:italic>\n                    and investigate the bactericidal activity of differential antimicrobial agents to its biofilm-forming\n                    <jats:italic toggle=\"yes\">S. aureus<\/jats:italic>\n                    . Between 32\n                    <jats:italic toggle=\"yes\">S. aureus<\/jats:italic>\n                    wild type (WT) and 32 SCVs selected from its WT, the amount of formed biofilm was compared. Vancomycin, daptomycin, rifampicin, and minocycline were exposed to biofilm-forming\n                    <jats:italic toggle=\"yes\">S. aureus<\/jats:italic>\n                    to determine viable bacterial counts and its susceptibility. The biofilm-producing quantify of SCVs was approximately twice that formed by its WT. Vancomycin and daptomycin reduce 4 logs the bacterial counts of biofilm-forming WT at 24 hours, but did not affect SCVs. Rifampicin and minocycline considerably decreased both WT and SCVs; however, both bacterial counts recovered to an initial number 48 hours later. These survival strains showed resistance to each drug, and\n                    <jats:italic toggle=\"yes\">rpoB<\/jats:italic>\n                    mutation or\n                    <jats:italic toggle=\"yes\">tet38<\/jats:italic>\n                    mRNA overexpression was confirmed.\n                  <\/jats:p>","DOI":"10.1089\/mdr.2020.0379","type":"journal-article","created":{"date-parts":[[2021,3,10]],"date-time":"2021-03-10T17:00:00Z","timestamp":1615395600000},"page":"1282-1289","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["<i>In vitro<\/i>\n                    Tolerability of Biofilm-Forming Trimethoprim-\/Sulfamethoxazole-Resistant Small Colony Variants of\n                    <i>Staphylococcus aureus<\/i>\n                    Against Various Antimicrobial Agents"],"prefix":"10.1177","volume":"27","author":[{"given":"Takumi","family":"Sato","sequence":"first","affiliation":[{"name":"Division of Clinical Infectious Diseases and Chemotherapy, Tohoku Medical and Pharmaceutical University, Sendai, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Uno","sequence":"additional","affiliation":[{"name":"Division of Clinical Infectious Diseases and Chemotherapy, Tohoku Medical and Pharmaceutical University, Sendai, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masato","family":"Kawamura","sequence":"additional","affiliation":[{"name":"Division of Clinical Infectious Diseases and Chemotherapy, Tohoku Medical and Pharmaceutical University, Sendai, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigeru","family":"Fujimura","sequence":"additional","affiliation":[{"name":"Division of Clinical Infectious Diseases and Chemotherapy, Tohoku Medical and Pharmaceutical University, Sendai, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2021,9,9]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1056\/NEJM199808203390806","article-title":"Staphylococcus aureus infections","volume":"339","author":"Lowy, F.D","year":"1998","unstructured":"Lowy, F.D. 1998. 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