{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T23:57:48Z","timestamp":1783727868574,"version":"3.55.0"},"reference-count":29,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Microbial Drug Resistance"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>The aim of this study was to assess the drivers of multidrug-resistant (MDR) bacterial infection development in coronavirus disease 2019 (COVID-19) and its impact on patient outcome.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Retrospective analysis on data from 32 consecutive patients with COVID-19, admitted to our intensive care unit (ICU) from March to May 2020. Outcomes considered were MDR infection and ICU mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Fifty percent of patients developed an MDR infection during ICU stay after a median time of 8 [4\u201311] days. Most common MDR pathogens were carbapenem-resistant\n                      <jats:italic toggle=\"yes\">Klebsiella pneumoniae<\/jats:italic>\n                      and\n                      <jats:italic toggle=\"yes\">Acinetobacter baumannii<\/jats:italic>\n                      , causing bloodstream infections and pneumonia. MDR infections were linked to a higher length of ICU stay (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.002), steroid therapy (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.011), and associated with a lower ICU mortality (odds ratio: 0.439, 95% confidence interval: 0.251\u20130.763;\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Low-dose aspirin intake was associated with both MDR infection (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.043) and survival (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.015). Among MDR patients, mortality was related with piperacillin-tazobactam use (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.035) and an earlier onset of MDR infection (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.042).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>MDR infections were a common complication in critically ill COVID-19 patients at our center. MDR risk was higher among those dwelling longer in the ICU and receiving steroids. However, MDR infections were not associated with a worse outcome.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/mdr.2020.0489","type":"journal-article","created":{"date-parts":[[2021,2,18]],"date-time":"2021-02-18T12:03:51Z","timestamp":1613649831000},"page":"1167-1175","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":54,"title":["Multidrug-Resistant Infections and Outcome of Critically Ill Patients with Coronavirus Disease 2019: A Single Center Experience"],"prefix":"10.1177","volume":"27","author":[{"given":"Arta","family":"Karruli","sequence":"first","affiliation":[{"name":"Department of Precision Medicine, University of Campania \u201cL. Vanvitelli\u201d, Napoli, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Filomena","family":"Boccia","sequence":"additional","affiliation":[{"name":"Department of Precision Medicine, University of Campania \u201cL. 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Vanvitelli\u201d, Napoli, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosanna","family":"De Rosa","sequence":"additional","affiliation":[{"name":"Intensive Care Unit, AORN Ospedali dei Colli-Monaldi Hospital, Napoli, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrizia","family":"Murino","sequence":"additional","affiliation":[{"name":"Intensive Care Unit, AORN Ospedali dei Colli-Monaldi Hospital, Napoli, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Ruocco","sequence":"additional","affiliation":[{"name":"Microbiology and Virology Laboratory, AORN Ospedali dei Colli-Monaldi Hospital, Napoli, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Corcione","sequence":"additional","affiliation":[{"name":"Intensive Care Unit, AORN Ospedali dei Colli-Monaldi Hospital, Napoli, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Andini","sequence":"additional","affiliation":[{"name":"Unit of Infectious and Transplant Medicine, AORN Ospedali dei Colli-Monaldi Hospital, Napoli, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosa","family":"Zampino","sequence":"additional","affiliation":[{"name":"Unit of Infectious and Transplant Medicine, AORN Ospedali dei Colli-Monaldi Hospital, Napoli, Italy."},{"name":"Department of Advanced Medical and Surgical Sciences, University of Campania \u201cL. 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