{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T11:28:12Z","timestamp":1790681292881,"version":"4.1.0"},"reference-count":43,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Microbial Drug Resistance"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:p>\n                    Fecal carriage of multidrug-resistant\n                    <jats:italic toggle=\"yes\">Escherichia coli<\/jats:italic>\n                    , particularly sequence type 131 (ST131), is becoming a global concern. This study aimed at determining the prevalence rate and molecular epidemiology of extended-spectrum\n                    <jats:italic toggle=\"yes\">\u03b2<\/jats:italic>\n                    -lactamase-producing\n                    <jats:italic toggle=\"yes\">E. coli<\/jats:italic>\n                    (ESBL-Ec), carbapenemase-producing\n                    <jats:italic toggle=\"yes\">E. coli<\/jats:italic>\n                    (CPEc), ceftazidime\/avibactam (CAZ\/AVI)-resistant\n                    <jats:italic toggle=\"yes\">E. coli<\/jats:italic>\n                    , and ST131 isolates in healthy fecal carriers in Tehran, Iran. Among 540 samples studied, 233 (43.1%) carried ESBL-Ec, with the majority (93.9%) harboring the\n                    <jats:italic toggle=\"yes\">bla<\/jats:italic>\n                    <jats:sub>CTX-M.<\/jats:sub>\n                    The carriage rate of CPEc was 2.5% (\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    \u2009=\u200914\/540), and\n                    <jats:italic toggle=\"yes\">bla<\/jats:italic>\n                    <jats:sub>NDM<\/jats:sub>\n                    gene was the predominant carbapenemase gene. Most CPEc isolates (\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    \u2009=\u200911\/14) was shown to be resistant to CAZ\/AVI. Among ESBL-Ec\/CPEc, 7.3% (\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    \u2009=\u200917\/233) belonged to\n                    <jats:italic toggle=\"yes\">E. coli<\/jats:italic>\n                    ST131 clone, which was identified by polymerase chain reaction and confirmed by multilocus sequence typing. The ST131 isolates genetically typed by pulsed-field gel electrophoresis were heterogeneous and four different plasmids were detected by plasmid typing, with the IncFIA\/FIB being the major type. Our findings disclose that the presence of carbapenem-resistant ST131 isolates, which are also resistant to CAZ\/AVI, contributes to the spread of resistant strains in the community. Therefore, screening and monitoring of such resistant clone in healthy people is necessary.\n                  <\/jats:p>","DOI":"10.1089\/mdr.2021.0001","type":"journal-article","created":{"date-parts":[[2021,10,26]],"date-time":"2021-10-26T09:09:14Z","timestamp":1635239354000},"page":"210-216","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":9,"title":["Prevalence of O25b-ST131\n                    <i>Escherichia coli<\/i>\n                    Clone: Fecal Carriage of Extended-Spectrum\n                    <i>\u03b2<\/i>\n                    -Lactamase and Carbapenemase\u2014Producing Isolates in Healthy Adults in Tehran, Iran"],"prefix":"10.1177","volume":"28","author":[{"given":"Azade","family":"Hajihasani","sequence":"first","affiliation":[{"name":"Department of Bacteriology, Pasteur Institute of Iran, Tehran, Iran."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mina","family":"Ebrahimi-Rad","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Pasteur Institute of Iran, Tehran, Iran."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masoumeh","family":"Rasoulinasab","sequence":"additional","affiliation":[{"name":"Department of Bacteriology, Pasteur Institute of Iran, Tehran, Iran."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad Mehdi","family":"Aslani","sequence":"additional","affiliation":[{"name":"Department of Bacteriology, Pasteur Institute of Iran, Tehran, Iran."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fereshteh","family":"Shahcheraghi","sequence":"additional","affiliation":[{"name":"Department of Bacteriology, Pasteur Institute of Iran, Tehran, Iran."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2022,2,14]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"crossref","first-page":"1941","DOI":"10.3389\/fmicb.2019.01941","article-title":"Understanding the epidemiology of multi-drug resistant gram-negative bacilli in the Middle East using a one health approach","volume":"10","author":"Dandachi I.","year":"2019","unstructured":"Dandachi I., , Chaddad A., , Hanna J., , Matta J., , and Daoud Z.. 2019. 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