{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T16:46:00Z","timestamp":1793897160505,"version":"4.8.0"},"reference-count":28,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Microbial Drug Resistance"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:p>\n                    We analyzed the association between antibiotic resistance and recurrent urinary tract infection (rUTI) by\n                    <jats:italic toggle=\"yes\">Escherichia coli<\/jats:italic>\n                    . Susceptibility levels to 14 antimicrobial agents and the presence of extended-spectrum \u03b2-lactamases (ESBL) were established using MicroScan. Incidences of multidrug resistant (MDR), extensively drug resistant (XDR), and ESBL-producer isolates as well as rUTIs were estimated. The time to recurrence was established adjusted for number of antibiotic-resistant families and MDR as predictors of interest, respectively. Overall, 8,553 urinary tract infection (UTI) cases related to\n                    <jats:italic toggle=\"yes\">E. coli<\/jats:italic>\n                    , including 963 rITU, were analyzed with levels of resistance &gt;30% in all cases, except for amikacin, nitrofurantoin, and carbapenems. The incidence of rUTI was of 11.3%, being 46.5%, 24.3%, and 42.5% for MDR, XDR, and ESBLs, respectively. Bivariate analysis showed that rUTI was associated with age, gender, resistance to specific antimicrobials, MDR, and XDR. The number of antibiotic families tested as resistant, MDR, XDR, gender, and age were associated with time to recurrence when adjusted for number of antibiotic families, and MDR, gender, and age were related when adjusted for MDR. High rates of antibiotic resistance to the usual antibiotics was observed in\n                    <jats:italic toggle=\"yes\">E. coli<\/jats:italic>\n                    causing UTI, with female sex, age, and antibiotic resistance being risk factors for the development of rUTI.\n                  <\/jats:p>","DOI":"10.1089\/mdr.2021.0052","type":"journal-article","created":{"date-parts":[[2021,8,27]],"date-time":"2021-08-27T12:51:23Z","timestamp":1630068683000},"page":"185-190","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":16,"title":["Recurrence of Urinary Tract Infections due to\n                    <i>Escherichia coli<\/i>\n                    and Its Association with Antimicrobial Resistance"],"prefix":"10.1177","volume":"28","author":[{"given":"Maria Angeles","family":"Orme\u00f1o","sequence":"first","affiliation":[{"name":"Escuela de Medicina, Universidad Cient\u00edfica del Sur, Lima, Per\u00fa."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Jos\u00e9","family":"Orme\u00f1o","sequence":"additional","affiliation":[{"name":"Escuela de Medicina, Universidad Cient\u00edfica del Sur, Lima, Per\u00fa."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio M.","family":"Quispe","sequence":"additional","affiliation":[{"name":"Escuela de Medicina, Universidad Continental, Lima, Peru."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel Angel","family":"Arias-Linares","sequence":"additional","affiliation":[{"name":"Escuela de Medicina, Universidad Peruana de Ciencias Aplicadas, Lima, Peru."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elba","family":"Linares","sequence":"additional","affiliation":[{"name":"Servicio de Microbiolog\u00eda, Hospital Nacional Edgardo Rebagliati Martins, Lima, Per\u00fa."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felix","family":"Loza","sequence":"additional","affiliation":[{"name":"Servicio de Microbiolog\u00eda, Hospital Nacional Edgardo Rebagliati Martins, Lima, Per\u00fa."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4431-2036","authenticated-orcid":false,"given":"Joaquim","family":"Ruiz","sequence":"additional","affiliation":[{"name":"Escuela de Medicina, Universidad Cient\u00edfica del Sur, Lima, Per\u00fa."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8384-2315","authenticated-orcid":false,"given":"Maria J.","family":"Pons","sequence":"additional","affiliation":[{"name":"Escuela de Medicina, Universidad Cient\u00edfica del Sur, Lima, Per\u00fa."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2022,2,14]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro3432"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00345-019-03071-4"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.12816\/0003256"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1177\/1756287219832172"},{"key":"e_1_3_4_6_2","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.ajic.2006.09.006","article-title":"Factors associated with health care-acquired urinary tract infection","volume":"35","author":"Graves N.","year":"2007","unstructured":"Graves N., , Tong E., , Morton A.P, et al. 2007. Factors associated with health care-acquired urinary tract infection. Am. J. Infect. Control. 35:387\u2013392.","journal-title":"Am. J. Infect. Control"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.3390\/antibiotics9090630"},{"key":"e_1_3_4_8_2","doi-asserted-by":"crossref","first-page":"927","DOI":"10.2147\/IDR.S153601","article-title":"Epidemiology and molecular characterization of multidrug-resistant Escherichia coli isolates harboring bla CTX-M group 1 extended-spectrum \u03b2-lactamases causing bacteremia and urinary tract infection in Manhi\u00e7a, Mozambique","volume":"11","author":"Guiral E.","year":"2018","unstructured":"Guiral E., , Pons M.J, , Vubil D., et al. 2018. Epidemiology and molecular characterization of multidrug-resistant Escherichia coli isolates harboring bla CTX-M group 1 extended-spectrum \u03b2-lactamases causing bacteremia and urinary tract infection in Manhi\u00e7a, Mozambique. Infect. Drug Resist. 11:927\u2013936.","journal-title":"Infect. 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