{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T00:56:07Z","timestamp":1778028967542,"version":"3.51.4"},"reference-count":43,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Microbial Drug Resistance"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:p>\n                    The increasing prevalence and dissemination of carbapenemase-producing\n                    <jats:italic toggle=\"yes\">Enterobacterales<\/jats:italic>\n                    represent a serious concern for public health. We studied the genetic features of a multidrug-resistant isolate of high-risk clone ST147\n                    <jats:italic toggle=\"yes\">Klebsiella pneumoniae<\/jats:italic>\n                    coharboring\n                    <jats:italic toggle=\"yes\">mcr<\/jats:italic>\n                    -1 and\n                    <jats:italic toggle=\"yes\">bla<\/jats:italic>\n                    <jats:sub>NDM-1<\/jats:sub>\n                    recovered from a human clinical urine sample in 2017 in Peru. Whole-genome sequencing and conjugation assays identified\n                    <jats:italic toggle=\"yes\">mcr-1<\/jats:italic>\n                    and\n                    <jats:italic toggle=\"yes\">bla<\/jats:italic>\n                    <jats:sub>NDM-1<\/jats:sub>\n                    genes on two different conjugative plasmids, which belong to IncI2 and IncFIB\/HI1B incompatibility groups, respectively. The presence of\n                    <jats:italic toggle=\"yes\">bla<\/jats:italic>\n                    <jats:sub>CTX-M-15<\/jats:sub>\n                    (in the studied isolate, located on the chromosome) and mutations in GyrA S83I and ParC S80I were detected, as expected for ST147. In addition, other \u03b2-lactamases (\n                    <jats:italic toggle=\"yes\">bla<\/jats:italic>\n                    <jats:sub>TEM-26<\/jats:sub>\n                    and\n                    <jats:italic toggle=\"yes\">bla<\/jats:italic>\n                    <jats:sub>OXA-1<\/jats:sub>\n                    ) and PMQR (\n                    <jats:italic toggle=\"yes\">qnrE2<\/jats:italic>\n                    and\n                    <jats:italic toggle=\"yes\">aac(6\u2032)-Ib-cr<\/jats:italic>\n                    ) among several resistance determinants were identified. The coexistence not previously described of these genes in the same high-risk clone is a cause for serious concern that supports the need for implementation of genomic surveillance studies.\n                  <\/jats:p>","DOI":"10.1089\/mdr.2021.0128","type":"journal-article","created":{"date-parts":[[2021,10,26]],"date-time":"2021-10-26T09:08:38Z","timestamp":1635239318000},"page":"171-179","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":12,"title":["Whole-Genome Analysis of a High-Risk Clone of\n                    <i>Klebsiella pneumoniae<\/i>\n                    ST147 Carrying Both\n                    <i>mcr-1<\/i>\n                    and\n                    <i>bla<\/i>\n                    <sub>NDM-1<\/sub>\n                    Genes in Peru"],"prefix":"10.1177","volume":"28","author":[{"given":"Edgar","family":"Gonzales-Escalante","sequence":"first","affiliation":[{"name":"Facultad de Farmacia y Bioqu\u00edmica, Instituto de Investigaciones en Bacteriolog\u00eda y Virolog\u00eda Molecular (IBaViM), Universidad de Buenos Aires, Buenos Aires, Argentina."},{"name":"Centro de Investigaciones Tecnol\u00f3gicas, Biom\u00e9dicas y Medioambientales \u2013 CITBM, Universidad Nacional Mayor de San Marcos, Lima, Per\u00fa."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melina","family":"Ruggiero","sequence":"additional","affiliation":[{"name":"Facultad de Farmacia y Bioqu\u00edmica, Instituto de Investigaciones en Bacteriolog\u00eda y Virolog\u00eda Molecular (IBaViM), Universidad de Buenos Aires, Buenos Aires, Argentina."},{"name":"CONICET, Buenos Aires, Argentina."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Louise","family":"Cerdeira","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Central Clinical School, Monash University, Melbourne, Australia."},{"name":"Department of Microbiology, Instituto de Ci\u00eancias Biom\u00e9dicas, Universidade de S\u00e3o Paulo, Sao Paulo, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernanda","family":"Esposito","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Instituto de Ci\u00eancias Biom\u00e9dicas, Universidade de S\u00e3o Paulo, Sao Paulo, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Herrison","family":"Fontana","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Instituto de Ci\u00eancias Biom\u00e9dicas, Universidade de S\u00e3o Paulo, Sao Paulo, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nilton","family":"Lincopan","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Instituto de Ci\u00eancias Biom\u00e9dicas, Universidade de S\u00e3o Paulo, Sao Paulo, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriel","family":"Gutkind","sequence":"additional","affiliation":[{"name":"Facultad de Farmacia y Bioqu\u00edmica, Instituto de Investigaciones en Bacteriolog\u00eda y Virolog\u00eda Molecular (IBaViM), Universidad de Buenos Aires, Buenos Aires, Argentina."},{"name":"CONICET, Buenos Aires, Argentina."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jose","family":"Di Conza","sequence":"additional","affiliation":[{"name":"Facultad de Farmacia y Bioqu\u00edmica, Instituto de Investigaciones en Bacteriolog\u00eda y Virolog\u00eda Molecular (IBaViM), Universidad de Buenos Aires, Buenos Aires, Argentina."},{"name":"CONICET, Buenos Aires, Argentina."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2022,2,14]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/1469-0691.12719"},{"key":"e_1_3_4_3_2","unstructured":"World Health Organization. 2017. 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Available at https:\/\/www.eucast.org\/fileadmin\/src\/media\/PDFs\/EUCAST_files\/Breakpoint_tables\/v_9.0_Breakpoint_Tables.pdf (accessed December20 2020)."},{"key":"e_1_3_4_14_2","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.diagmicrobio.2018.04.010","article-title":"Rapid multiplex polymerase chain reaction for detection of mcr-1 to mcr-5 genes","volume":"92","author":"Lescat M.","year":"2018","unstructured":"Lescat M., , Poirel L., , and Nordmann P.. 2018. Rapid multiplex polymerase chain reaction for detection of mcr-1 to mcr-5 genes. Diagn. Microbiol. Infect. Dis. 92:267\u2013269.","journal-title":"Diagn. Microbiol. Infect. 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(In Spanish.)","DOI":"10.26633\/RPSP.2020.61"},{"key":"e_1_3_4_23_2","doi-asserted-by":"crossref","first-page":"e02450","DOI":"10.1128\/AAC.02450-18","article-title":"Updated prevalence of mcr-like genes among Escherichia coli and Klebsiella pneumoniae in the SENTRY program and characterization of mcr-1.11 variant","volume":"63","author":"Deshpande L.M.","year":"2019","unstructured":"Deshpande L.M., , Hubler C., , Davis A.P, , and Castanheira M.. 2019. Updated prevalence of mcr-like genes among Escherichia coli and Klebsiella pneumoniae in the SENTRY program and characterization of mcr-1.11 variant. Antimicrob. Agents Chemother. 63:e02450-18.","journal-title":"Antimicrob. Agents Chemother"},{"key":"e_1_3_4_24_2","first-page":"2019","article-title":"TL-1003","volume":"25","author":"Gonzales-Escalante E.","year":"2019","unstructured":"Gonzales-Escalante E., , Gutkind G., , and Di Conza J.. 2019. TL-1003. Molecular characterization of ESBL-producing and colistin resistant Escherichia coli isolated from chickens and pigs in Peru. XV Argentine Congress of Microbiology [in Spanish]. CAM 2019, Buenos Aires City (accessed September, 25\u201327, 2019).","journal-title":"Molecular characterization of ESBL-producing and colistin resistant Escherichia coli isolated from chickens and pigs in Peru. XV Argentine Congress of Microbiology [in Spanish]. CAM 2019, Buenos Aires City (accessed September"},{"key":"e_1_3_4_25_2","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.jgar.2019.02.015","article-title":"Novel patterns in the molecular epidemiology of KPC-producing Klebsiella pneumoniae in Tucuman, Argentina","volume":"19","author":"Jure M.A.","year":"2019","unstructured":"Jure M.A., , Castillo M., , Musa H.E, et al. 2019. Novel patterns in the molecular epidemiology of KPC-producing Klebsiella pneumoniae in Tucuman, Argentina. J. Glob. Antimicrob. 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Agents"},{"key":"e_1_3_4_30_2","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.jgar.2016.12.011","article-title":"Characterisation of the first KPC-2-producing Klebsiella pneumoniae ST340 from Peru","volume":"9","author":"Horna G.","year":"2017","unstructured":"Horna G., , Velasquez J., , Fern\u00e1ndez N., , Tamariz J., , and Ruiz J.. 2017. Characterisation of the first KPC-2-producing Klebsiella pneumoniae ST340 from Peru. J. Glob. Antimicrob. Resist. 9:36\u201340.","journal-title":"J. Glob. Antimicrob. Resist"},{"key":"e_1_3_4_31_2","doi-asserted-by":"crossref","first-page":"E1392","DOI":"10.3390\/microorganisms8091392","article-title":"Spread of ST348 Klebsiella pneumoniae producing NDM-1 in a Peruvian Hospital","volume":"8","author":"Pons M.J.","year":"2020","unstructured":"Pons M.J., , Mar\u00ed-Almirall M., , Yma\u00f1a B., et al. 2020. Spread of ST348 Klebsiella pneumoniae producing NDM-1 in a Peruvian Hospital. 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Dis. 67:1804\u20131815."},{"key":"e_1_3_4_36_2","doi-asserted-by":"crossref","first-page":"2127","DOI":"10.1093\/jac\/dkx078","article-title":"Citrobacter braakii carrying plasmid-borne mcr-1 colistin resistance gene from ready-to-eat food from a market in the Chaco region of Bolivia","volume":"72","author":"Sennati S.","year":"2017","unstructured":"Sennati S., , Di Pilato V., , Riccobono E., et al. 2017. Citrobacter braakii carrying plasmid-borne mcr-1 colistin resistance gene from ready-to-eat food from a market in the Chaco region of Bolivia. J. Antimicrob. Chemother. 72:2127\u20132129.","journal-title":"J. Antimicrob. Chemother"},{"key":"e_1_3_4_37_2","first-page":"93","article-title":"Current scenario of plasmid-mediated colistin resistance in Latin America","volume":"51","author":"Quiroga C.","year":"2019","unstructured":"Quiroga C., , Nastro M., , and Di Conza J.. 2019. Current scenario of plasmid-mediated colistin resistance in Latin America. Rev. Argent. 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