{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T19:32:14Z","timestamp":1777923134182,"version":"3.51.4"},"reference-count":25,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Microbial Drug Resistance"],"published-print":{"date-parts":[[2022,5,1]]},"abstract":"<jats:p>\n                    The spread of\n                    <jats:bold>c<\/jats:bold>\n                    arbapenem-resistant Enterobacterales has raised concern in clinical settings due to the limited therapeutic options available. OXA-48\u2013like enzymes are still sporadic in South America. The aim of this study was to characterize a multidrug-resistant\n                    <jats:italic toggle=\"yes\">Escherichia coli<\/jats:italic>\n                    isolate from a hospitalized patient in Buenos Aires city.\n                  <\/jats:p>\n                  <jats:p>\n                    The isolate was characterized phenotypically by determination of its susceptibility pattern, synergistic and colorimetric tests, and molecularly, by PCR, whole genome sequencing, and plasmid analysis. It belonged to ST-744, phylogroup A, and serotype O162\/O89: H9. It remained susceptible to ceftazidime, meropenem, aminoglycosides, trimethoprim\/sulfamethoxazole, and tigecycline. The presence of\n                    <jats:italic toggle=\"yes\">bla<\/jats:italic>\n                    <jats:sub>OXA-232<\/jats:sub>\n                    harbored by a nonconjugative plasmid ColKp3, and\n                    <jats:italic toggle=\"yes\">bla<\/jats:italic>\n                    <jats:sub>CTX-M-14<\/jats:sub>\n                    ,\n                    <jats:italic toggle=\"yes\">mcr-1.1,<\/jats:italic>\n                    and\n                    <jats:italic toggle=\"yes\">fosL1<\/jats:italic>\n                    in 2 conjugative plasmids, together with their genetic environment, was revealed. To the best of our knowledge, this is the first report of the coproduction of the enzyme OXA-232 and the\n                    <jats:italic toggle=\"yes\">mcr-1.1<\/jats:italic>\n                    gene in an\n                    <jats:italic toggle=\"yes\">E. coli<\/jats:italic>\n                    clinical isolate in South America in a patient who had not received colistin therapy.\n                  <\/jats:p>","DOI":"10.1089\/mdr.2021.0167","type":"journal-article","created":{"date-parts":[[2022,3,11]],"date-time":"2022-03-11T14:56:33Z","timestamp":1647010593000},"page":"511-516","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Molecular and Phenotypic Characterization of a Multidrug-Resistant\n                    <i>Escherichia coli<\/i>\n                    Coproducing OXA-232 and MCR\n                    <i>-<\/i>\n                    1.1 in Argentina"],"prefix":"10.1177","volume":"28","author":[{"given":"Javier F.","family":"Garcia","sequence":"first","affiliation":[{"name":"C\u00e1tedra de Microbiolog\u00eda Cl\u00ednica, Laboratorio de Bacteriolog\u00eda, Departamento de Bioqu\u00edmica Cl\u00ednica, Facultad de Farmacia y Bioqu\u00edmica, Hospital de Cl\u00ednicas Jos\u00e9 de San Mart\u00edn, Universidad de Buenos Aires, Buenos Aires, Argentina."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcela","family":"Nastro","sequence":"additional","affiliation":[{"name":"C\u00e1tedra de Microbiolog\u00eda Cl\u00ednica, Laboratorio de Bacteriolog\u00eda, Departamento de Bioqu\u00edmica Cl\u00ednica, Facultad de Farmacia y Bioqu\u00edmica, Hospital de Cl\u00ednicas Jos\u00e9 de San Mart\u00edn, INFIBIOC, Universidad de Buenos Aires, Buenos Aires, Argentina."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Dabos","sequence":"additional","affiliation":[{"name":"Evolutionary Systems Genetics of Microbes Laboratory, Center for Plant Biotechnology and Genomics (CBGP, UPM-INIA) Technical University of Madrid, Madrid, Spain."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Josefina","family":"Campos","sequence":"additional","affiliation":[{"name":"Plataforma Gen\u00f3mica y Bioinform\u00e1tica ANLIS \u201cDr Carlos G Malbran\u201d, Buenos Aires, Argentina."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"German","family":"Traglia","sequence":"additional","affiliation":[{"name":"Departamento de Desarrollo Biotecnol\u00f3gico, Instituto de Higiene, Facultad de Medicina, Universidad de la Rep\u00fablica, Montevideo, Uruguay."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cecilia Vera","family":"Ocampo","sequence":"additional","affiliation":[{"name":"Servicio de Infectolog\u00eda, Sanatorio Mater Dei, Ciudad Aut\u00f3noma de Buenos Aires, Buenos Aires, Argentina."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angela","family":"Famiglietti","sequence":"additional","affiliation":[{"name":"C\u00e1tedra de Microbiolog\u00eda Cl\u00ednica, Laboratorio de Bacteriolog\u00eda, Departamento de Bioqu\u00edmica Cl\u00ednica, Facultad de Farmacia y Bioqu\u00edmica, Hospital de Cl\u00ednicas Jos\u00e9 de San Mart\u00edn, INFIBIOC, Universidad de Buenos Aires, Buenos Aires, Argentina."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos H.","family":"Rodriguez","sequence":"additional","affiliation":[{"name":"C\u00e1tedra de Microbiolog\u00eda Cl\u00ednica, Laboratorio de Bacteriolog\u00eda, Departamento de Bioqu\u00edmica Cl\u00ednica, Facultad de Farmacia y Bioqu\u00edmica, Hospital de Cl\u00ednicas Jos\u00e9 de San Mart\u00edn, INFIBIOC, Universidad de Buenos Aires, Buenos Aires, Argentina."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos A.","family":"Vay","sequence":"additional","affiliation":[{"name":"C\u00e1tedra de Microbiolog\u00eda Cl\u00ednica, Laboratorio de Bacteriolog\u00eda, Departamento de Bioqu\u00edmica Cl\u00ednica, Facultad de Farmacia y Bioqu\u00edmica, Hospital de Cl\u00ednicas Jos\u00e9 de San Mart\u00edn, INFIBIOC, Universidad de Buenos Aires, Buenos Aires, Argentina."},{"name":"Laboratorio de Bacteriolog\u00eda. 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