{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T01:15:49Z","timestamp":1784078149233,"version":"3.55.0"},"reference-count":23,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Microbial Drug Resistance"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:p>\n                    Vancomycin-resistant\n                    <jats:italic toggle=\"yes\">Enterococcus faecium<\/jats:italic>\n                    (VREfm) is one of the most important nosocomial pathogens with limited therapeutic alternatives. In this study, we followed the trends of VREfm and\n                    <jats:italic toggle=\"yes\">E. faecium<\/jats:italic>\n                    causing bloodstream infections (BSIs) in a Spanish hospital, from 2011 to 2020. During this period, 832\n                    <jats:italic toggle=\"yes\">E. faecium<\/jats:italic>\n                    strains were isolated and 121 (14.5%) were vancomycin resistant. Nineteen of 101 BSIs (18.8%) caused by\n                    <jats:italic toggle=\"yes\">E. faecium<\/jats:italic>\n                    were due to VREfm. The number of BSI-producing\n                    <jats:italic toggle=\"yes\">E. faecium<\/jats:italic>\n                    isolates increased significantly over the past 5 years, with the percentage of invasive VREfm isolates being substantially higher than the average values in Europe and especially in Spain (&lt;3%). VREfm isolates recovered in 2018 (28) and BSI-producing isolates from 2019 (3) and 2020 (2) were molecularly characterized. All were positive for\n                    <jats:italic toggle=\"yes\">vanA<\/jats:italic>\n                    and belonged to sequence type (ST) 80 (28) or ST117 (5), within clonal complex 17. The isolates were only susceptible to linezolid, although most of them were also susceptible (dose dependent) to daptomycin. We report for the first time the establishment and persistence of the VREfm ST80 and ST117 clones in a Spanish hospital. The spread and establishment of hospital-adapted, multidrug-resistant VREfm clones in health care settings are cause for concern and may precede an increment in the BSIs caused by them.\n                  <\/jats:p>","DOI":"10.1089\/mdr.2021.0171","type":"journal-article","created":{"date-parts":[[2021,10,27]],"date-time":"2021-10-27T12:01:18Z","timestamp":1635336078000},"page":"217-221","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":17,"title":["Establishment and Persistence of Glycopeptide-Resistant\n                    <i>Enterococcus faecium<\/i>\n                    ST80 and ST117 Clones Within a Health Care Facility Located in a Low-Prevalence Geographical Region"],"prefix":"10.1177","volume":"28","author":[{"given":"Carlos","family":"Rodr\u00edguez-Lucas","sequence":"first","affiliation":[{"name":"Servicio de Microbiolog\u00eda, Hospital Universitario de Cabue\u00f1es, Gij\u00f3n, Spain."},{"name":"Grupo de Microbiolog\u00eda Traslacional, Instituto de Investigaci\u00f3n Sanitaria del Principado de Asturias, Oviedo, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier","family":"Fern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Grupo de Microbiolog\u00eda Traslacional, Instituto de Investigaci\u00f3n Sanitaria del Principado de Asturias, Oviedo, Spain."},{"name":"Servicio de Microbiolog\u00eda, Hospital Universitario Central de Asturias, Oviedo, Spain."},{"name":"Research and Innovation, Artificial Intelligence and Statistics Department, Pragmatech AI Solutions, Oviedo, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"Raya","sequence":"additional","affiliation":[{"name":"Unidad de Microbiolog\u00eda, Hospital El Bierzo, Ponferrada, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Bahamonde","sequence":"additional","affiliation":[{"name":"Servicio de Medicina Interna, Hospital El Bierzo, Ponferrada, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Quiroga","sequence":"additional","affiliation":[{"name":"Servicio de Medicina Preventiva, Hospital El Bierzo, Ponferrada, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosario","family":"Mu\u00f1oz","sequence":"additional","affiliation":[{"name":"Unidad de Enfermer\u00eda Servicio de Medicina Interna, Hospital El Bierzo, Ponferrada, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Rosario","family":"Rodicio","sequence":"additional","affiliation":[{"name":"Grupo de Microbiolog\u00eda Traslacional, Instituto de Investigaci\u00f3n Sanitaria del Principado de Asturias, Oviedo, Spain."},{"name":"Departamento de Biolog\u00eda Funcional, \u00c1rea de Microbiolog\u00eda, Universidad de Oviedo, Oviedo, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2022,2,14]]},"reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1093\/jac\/dks469","article-title":"Twenty-five years of shared life with vancomycin-resistant enterococci: is it time to divorce","volume":"68","author":"Cattoir V.","year":"2013","unstructured":"Cattoir V., , and Leclercq R.. 2013. Twenty-five years of shared life with vancomycin-resistant enterococci: is it time to divorce. J. Antimicrob. Chemother. 68:731\u2013742.","journal-title":"J. Antimicrob. Chemother"},{"key":"e_1_3_5_3_2","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1093\/jac\/dkn449","article-title":"Large clonal outbreak of multidrug-resistant CC17 ST17 Enterococcus faecium containing Tn5382 in a Spanish hospital","volume":"63","author":"Valdezate S.","year":"2009","unstructured":"Valdezate S., , Labayru C., , Navarro A., et al. 2009. Large clonal outbreak of multidrug-resistant CC17 ST17 Enterococcus faecium containing Tn5382 in a Spanish hospital. J. Antimicrob. Chemother. 63:17\u201320.","journal-title":"J. Antimicrob. Chemother"},{"key":"e_1_3_5_4_2","doi-asserted-by":"publisher","DOI":"10.1086\/421946"},{"key":"e_1_3_5_5_2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1017\/ice.2019.296","article-title":"Antimicrobial-resistant pathogens associated with adult healthcare-associated infections: summary of data reported to the National Healthcare Safety Network, 2015\u20132017","volume":"41","author":"Weiner-Lastinger L.M.","year":"2019","unstructured":"Weiner-Lastinger L.M., , Abner S., , Edwards J.R, et al. 2019. Antimicrobial-resistant pathogens associated with adult healthcare-associated infections: summary of data reported to the National Healthcare Safety Network, 2015\u20132017. Infect. Control Hosp. Epidemiol. 41:1\u201318.","journal-title":"Infect. Control Hosp. Epidemiol"},{"key":"e_1_3_5_6_2","first-page":"ECDC","article-title":"European Centre for Disease Prevention and Control","author":"ECDC","year":"2020","unstructured":"ECDC. 2020. European Centre for Disease Prevention and Control. Antimicrobial resistance in the EU\/EEA (EARS-Net)\u2014Annual Epidemiological Report 2019. Stockholm: ECDC.","journal-title":"Antimicrobial resistance in the EU\/EEA (EARS-Net)\u2014Annual Epidemiological Report 2019"},{"key":"e_1_3_5_7_2","first-page":"ECDC","article-title":"European Centre for Disease Prevention and Control","author":"ECDC","year":"2019","unstructured":"ECDC. 2019. European Centre for Disease Prevention and Control. Surveillance of antimicrobial resistance in Europe 2018. Stockholm: ECDC.","journal-title":"Surveillance of antimicrobial resistance in Europe 2018"},{"key":"e_1_3_5_8_2","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1093\/jac\/dkr545","article-title":"Clonal outbreak of ST17 multidrug-resistant Enterococcus faecium harbouring an Inc18-like::Tn1546 plasmid in a haemo-oncology ward of a Spanish hospital","volume":"67","author":"Valdezate S.","year":"2012","unstructured":"Valdezate S., , Miranda C., , Navarro A., et al. 2012. Clonal outbreak of ST17 multidrug-resistant Enterococcus faecium harbouring an Inc18-like::Tn1546 plasmid in a haemo-oncology ward of a Spanish hospital. J. Antimicrob. Chemother. 67:832\u2013836.","journal-title":"J. Antimicrob. Chemother"},{"key":"e_1_3_5_9_2","first-page":"430","article-title":"Study of the first outbreak of vanA Enterococcus faecium in the Canary Islands","volume":"28","author":"Montesinos I.","year":"2010","unstructured":"Montesinos I., , Campos S., , Ramos M.J, et al. 2010. Study of the first outbreak of vanA Enterococcus faecium in the Canary Islands. Enferm. Infecc. Microbiol. Clin. 28:430\u2013434.","journal-title":"Enferm. Infecc. Microbiol. Clin"},{"key":"e_1_3_5_10_2","doi-asserted-by":"publisher","DOI":"10.1177\/1757177416687832"},{"key":"e_1_3_5_11_2","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.eimc.2016.04.002","article-title":"Characterization and rapid control of a vancomycin-resistant Enterococcus faecium (VREF) outbreak in a renal transplant unit in Spain: the environment matters","volume":"35","author":"Herrera S.","year":"2017","unstructured":"Herrera S., , Sorl\u00ed L., , P\u00e9rez-S\u00e1ez M.J, et al. 2017. Characterization and rapid control of a vancomycin-resistant Enterococcus faecium (VREF) outbreak in a renal transplant unit in Spain: the environment matters. Enferm. Infecc. Microbiol. Clin. 35:5\u201311.","journal-title":"Enferm. Infecc. Microbiol. 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