{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T07:21:14Z","timestamp":1791444074456,"version":"4.3.3"},"reference-count":14,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Microbial Drug Resistance"],"published-print":{"date-parts":[[2022,3,1]]},"abstract":"\n Vancomycin-resistant enterococcal (VRE) bacteremia is associated with higher mortality rates and longer hospitalizations than vancomycin-sensitive enterococcal (VSE) bacteremia. A 67-year-old man with a right psoas abscess and pacemaker-associated tricuspid valve endocarditis in September 2020 grew VSE\n Enterococcus faecium<\/jats:italic>\n from blood cultures that cleared after administration of intravenous vancomycin and gentamicin. Subsequently, he underwent tricuspid valve repair, pacemaker removal, and partial lead extraction. Valve and postoperative blood cultures grew VRE\n E. faecium<\/jats:italic>\n , which cleared after administration of intravenous daptomycin. One VSE and two VRE isolates were collected and sequenced. All isolates belonged to\n E. faecium<\/jats:italic>\n multilocus sequence type ST17 and were closely related, having <20 mutations in pairwise genome comparisons. Vancomycin resistance was due to the acquisition of a plasmid-encoded VanA operon. None of the isolates encoded the virulence factors\n asa1<\/jats:italic>\n ,\n gelE<\/jats:italic>\n ,\n cylA<\/jats:italic>\n , or\n hyl<\/jats:italic>\n ; all encoded a homologue of\n efaAfm<\/jats:italic>\n . VSE\n E. faecium<\/jats:italic>\n , but not VRE\n E. faecium<\/jats:italic>\n isolates, encoded a glucose transporter gene mutation. Two VRE\n E. faecium<\/jats:italic>\n isolates formed more robust biofilms than the VSE\n E. faecium<\/jats:italic>\n isolate (\n p<\/jats:italic>\n \u2009<\u20090.001). The VRE\n E. faecium<\/jats:italic>\n isolates, which generated larger biofilms than the VSE\n E. faecium<\/jats:italic>\n isolate, could have remained protected in the heart valve and only caused bacteremia when disrupted during cardiac surgery. This study demonstrates that bacteria detected in the bloodstream of patients with endocarditis may not fully represent the organisms adherent to the cardiac valves or indwelling devices.\n <\/jats:p>","DOI":"10.1089\/mdr.2021.0233","type":"journal-article","created":{"date-parts":[[2021,12,17]],"date-time":"2021-12-17T10:29:05Z","timestamp":1639736945000},"page":"382-385","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Detection of Vancomycin-Resistant\n Enterococcus faecium<\/i>\n Endocarditis After Clearance of Vancomycin-Sensitive\n Enterococcus faecium<\/i>\n Bacteremia"],"prefix":"10.1177","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4079-0620","authenticated-orcid":false,"given":"Mary Catherine","family":"McEllistrem","sequence":"first","affiliation":[{"name":"VA Pittsburgh Healthcare System, Infectious Diseases Section, Pittsburgh, Pennsylvania, USA."},{"name":"Division of Infectious Diseases, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hayley R.","family":"Nordstrom","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aaron","family":"Lucas","sequence":"additional","affiliation":[{"name":"VA Pittsburgh Healthcare System, Infectious Diseases Section, Pittsburgh, Pennsylvania, USA."},{"name":"Division of Infectious Diseases, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brooke K.","family":"Decker","sequence":"additional","affiliation":[{"name":"VA Pittsburgh Healthcare System, Infectious Diseases Section, Pittsburgh, Pennsylvania, USA."},{"name":"Division of Infectious Diseases, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daria","family":"Van Tyne","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2022,3,4]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1017\/ice.2015.228"},{"key":"e_1_3_4_3_2","first-page":"175","volume":"135","author":"Fridkin S.K.","year":"2001","unstructured":"Fridkin S.K., , Edwards J.R., , Courval J.M., et al. 2001. The effect of vancomycin and third-generation cephalosporins on prevalence of vancomycin-resistant enterococci in 126 U.S. adult intensive care units. Ann. Intern. Med. 135:175\u2013183.","journal-title":"The effect of vancomycin and third-generation cephalosporins on prevalence of vancomycin-resistant enterococci in 126 U.S. adult intensive care units. Ann. Intern. 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