{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T19:33:19Z","timestamp":1777923199910,"version":"3.51.4"},"reference-count":31,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Microbial Drug Resistance"],"published-print":{"date-parts":[[2022,5,1]]},"abstract":"<jats:p>\n                    This retrospective study aims to describe the etiology and resistance patterns of pathogens causing bacteremia in children with solid tumors in a tertiary pediatric hematology-oncology center in Jerusalem, Israel (2011\u20132019). Factors associated with multidrug-resistant (MDR) bacteremia and mortality were analyzed. A total of 228 pathogens were isolated in 126 patients; 61.0% were gram-negative rods (GNR) and 38.2% were gram-positive cocci (GPC). The most common pathogens were\n                    <jats:italic toggle=\"yes\">Klebsiella pneumoniae<\/jats:italic>\n                    (19.3%),\n                    <jats:italic toggle=\"yes\">Escherichia coli<\/jats:italic>\n                    (17.5%), and coagulase-negative staphylococci (16.2%). The proportion of MDR-GNR was 18.2%, while the proportion of MDR-GPC was 55.2%. In logistic regression analysis, breakthrough bacteremia on a penicillin-group antibiotic (odds ratio [OR] 5.69, [95% confidence interval 1.42\u201322.76],\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    -value\u2009=\u20090.014) was associated and underlying diagnosis of neuroblastoma was inversely associated (OR 0.17, [0.04\u20130.81],\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    -value\u2009=\u20090.026) with MDR-GNR bacteremia; while the previous hospitalizations' duration (OR 1.032\/day, [1.01\u20131.06],\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    -value\u2009=\u20090.007) and oncologic treatment intensity (OR 2.19, [1.08\u20134.45,\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    -value\u2009=\u20090.03) were associated with MDR-GPC bacteremia. Shock, prolonged profound neutropenia, and pediatric intensive care unit (PICU) admission were associated with 7-day mortality; and relapsed disease, oncologic treatment intensity, prolonged profound neutropenia, and PICU admission\u2014with 30-day mortality in the univariate analyses. Empirical antibiotic choice should be based on factors associated with MDR infections in this specific population.\n                  <\/jats:p>","DOI":"10.1089\/mdr.2021.0256","type":"journal-article","created":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T11:32:02Z","timestamp":1648812722000},"page":"601-610","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Bacteremia in Children with Solid Tumors: Etiology, Antimicrobial Susceptibility, Factors Associated with Multidrug Resistance, and Mortality"],"prefix":"10.1177","volume":"28","author":[{"given":"Amit","family":"Ginzburg","sequence":"first","affiliation":[{"name":"Pediatric Infectious Diseases Unit, Faculty of Medicine, Hebrew University of Jerusalem, Hadassah Medical Center, Jerusalem, Israel."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gal","family":"Goldstein","sequence":"additional","affiliation":[{"name":"The Dyna &amp; Fala Weinstock Department of Pediatric Hematology Oncology, Faculty of Medicine, Hebrew University of Jerusalem, Hadassah Medical Center, Jerusalem, Israel."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dror","family":"Raviv","sequence":"additional","affiliation":[{"name":"The Dyna &amp; Fala Weinstock Department of Pediatric Hematology Oncology, Faculty of Medicine, Hebrew University of Jerusalem, Hadassah Medical Center, Jerusalem, Israel."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hodaya","family":"Cohen","sequence":"additional","affiliation":[{"name":"The Dyna &amp; Fala Weinstock Department of Pediatric Hematology Oncology, Faculty of Medicine, Hebrew University of Jerusalem, Hadassah Medical Center, Jerusalem, Israel."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sigal","family":"Weinreb","sequence":"additional","affiliation":[{"name":"The Dyna &amp; Fala Weinstock Department of Pediatric Hematology Oncology, Faculty of Medicine, Hebrew University of Jerusalem, Hadassah Medical Center, Jerusalem, Israel."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dan","family":"Harlev","sequence":"additional","affiliation":[{"name":"The Dyna &amp; Fala Weinstock Department of Pediatric Hematology Oncology, Faculty of Medicine, Hebrew University of Jerusalem, Hadassah Medical Center, Jerusalem, Israel."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adi","family":"Nitsan-Luques","sequence":"additional","affiliation":[{"name":"The Dyna &amp; Fala Weinstock Department of Pediatric Hematology Oncology, Faculty of Medicine, Hebrew University of Jerusalem, Hadassah Medical Center, Jerusalem, Israel."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammad Yacoub","family":"Abou Saoud","sequence":"additional","affiliation":[{"name":"The Dyna &amp; Fala Weinstock Department of Pediatric Hematology Oncology, Faculty of Medicine, Hebrew University of Jerusalem, Hadassah Medical Center, Jerusalem, Israel."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9192-7164","authenticated-orcid":false,"given":"Jacob","family":"Strahilevitz","sequence":"additional","affiliation":[{"name":"Department of Clinical Microbiology and Infectious Diseases, Faculty of Medicine, Hebrew University of Jerusalem, Hadassah Medical Center, Jerusalem, Israel."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9614-7274","authenticated-orcid":false,"given":"Diana","family":"Averbuch","sequence":"additional","affiliation":[{"name":"Pediatric Infectious Diseases Unit, Faculty of Medicine, Hebrew University of Jerusalem, Hadassah Medical Center, Jerusalem, Israel."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2022,5,17]]},"reference":[{"key":"e_1_3_6_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.27978"},{"key":"e_1_3_6_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/00043426-199709000-00001"},{"key":"e_1_3_6_4_2","doi-asserted-by":"publisher","DOI":"10.1080\/08880018.2017.1396386"},{"key":"e_1_3_6_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/MPH.0000000000001814"},{"key":"e_1_3_6_6_2","doi-asserted-by":"publisher","DOI":"10.2147\/IDR.S70486"},{"key":"e_1_3_6_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.24995"},{"key":"e_1_3_6_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.21070"},{"key":"e_1_3_6_9_2","doi-asserted-by":"publisher","DOI":"10.1080\/08880018.2019.1667462"},{"key":"e_1_3_6_10_2","doi-asserted-by":"publisher","DOI":"10.7314\/APJCP.2015.16.14.5691"},{"key":"e_1_3_6_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2005.01.020"},{"key":"e_1_3_6_12_2","first-page":"2417","article-title":"Bacteria causing bacteremia in pediatric cancer patients presenting with febrile neutropenia\u2014species distribution and susceptibility patterns","volume":"21","author":"Miedema K.G.","year":"2013","unstructured":"Miedema K.G., , Winter R.H, , Ammann R.A, et al. 2013. Bacteria causing bacteremia in pediatric cancer patients presenting with febrile neutropenia\u2014species distribution and susceptibility patterns. Support. Care Cancer, 21:2417\u20132426.","journal-title":"Support. Care Cancer"},{"key":"e_1_3_6_13_2","doi-asserted-by":"publisher","DOI":"10.1097\/MPH.0000000000000440"},{"key":"e_1_3_6_14_2","doi-asserted-by":"crossref","first-page":"e0162178","DOI":"10.1371\/journal.pone.0162178","article-title":"Infectious complications during tandem high-dose chemotherapy and autologous stem cell transplantation for children with high-risk or recurrent solid tumors","volume":"11","author":"Choi Y.B.","year":"2016","unstructured":"Choi Y.B., , Yi E.S, , Kang J.M, et al. 2016. Infectious complications during tandem high-dose chemotherapy and autologous stem cell transplantation for children with high-risk or recurrent solid tumors. 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