{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T10:30:54Z","timestamp":1790677854743,"version":"4.1.0"},"reference-count":28,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Microbial Drug Resistance"],"published-print":{"date-parts":[[2022,6,1]]},"abstract":"\n Background:<\/jats:title>\n \n Acinetobacter baumannii<\/jats:italic>\n can cause difficult-to-treat infections because it can acquire extensive antimicrobial resistance mechanisms. We aim to describe the antimicrobial resistance pattern and the genetic basis of carbapenem-nonsusceptible\n A. baumannii<\/jats:italic>\n isolates in a University Hospital in Romania, a country where multidrug-resistant\n A. baumannii<\/jats:italic>\n is widespread.\n <\/jats:p>\n <\/jats:sec>\n \n Methods:<\/jats:title>\n \n We collected 104 consecutive meropenem-nonsusceptible\n A. baumannii<\/jats:italic>\n isolates from 104 patients (36% female, mean age [SD] of 63 [16] years) between May 2015 and August 2017 from a large tertiary center in Romania. Whole-genome sequencing of representative isolates from amplified fragment length polymorphism clusters was used to determine clonality and resistance patterns.\n <\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n All isolates were resistant to piperacillin\/tazobactam, ceftazidime, and ciprofloxacin; 88.5% to gentamicin; and 90.4% to trimethoprim\/sulfamethoxazole. In contrast, 79.8% and 99.0% were susceptible to tobramycin and colistin, respectively. The only isolate resistant to colistin had an minimum inhibitory concentration (MIC) of \u226516\u2009mg\/L. The\n \n bla\n OXA-24<\/jats:sub>\n <\/jats:italic>\n gene was detected in 79.1% and\n \n bla\n OXA-23<\/jats:sub>\n <\/jats:italic>\n in 20.9% of the isolates. In one isolate,\n \n bla\n OXA-23<\/jats:sub>\n <\/jats:italic>\n was copresent with\n \n bla\n OXA-24<\/jats:sub>\n <\/jats:italic>\n . ST502 (Oxford scheme) was the most prevalent sequence type and was exclusively associated with\n \n bla\n OXA-24<\/jats:sub>\n <\/jats:italic>\n .\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions:<\/jats:title>\n \n ST502 associated with\n \n bla\n OXA-24<\/jats:sub>\n <\/jats:italic>\n was frequently observed in the region where carbapenem-nonsusceptible\n A. baumannii<\/jats:italic>\n was found to be endemic. In these isolates, tobramycin and colistin might be the remaining therapeutic options. Due to differences in gentamicin and tobramycin resistance in these isolates, surveillance data should not group gentamicin, tobramycin, and amikacin together as aminoglycosides.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1089\/mdr.2021.0274","type":"journal-article","created":{"date-parts":[[2022,5,19]],"date-time":"2022-05-19T09:15:47Z","timestamp":1652951747000},"page":"636-644","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["High Prevalence of ST502 Carrying an OXA-24 Carbapenemase gene in Carbapenem-Nonsusceptible\n Acinetobacter baumannii-calcoaceticus<\/i>\n Isolates in Romania"],"prefix":"10.1177","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4779-2191","authenticated-orcid":false,"given":"Erlangga","family":"Yusuf","sequence":"first","affiliation":[{"name":"Department of Medical Microbiology and Infectious Diseases, Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuela","family":"Tompa","sequence":"additional","affiliation":[{"name":"Regional Institute of Gastroenterology and Hepatology, Cluj-Napoca, Romania."},{"name":"Molecular Science, Microbiology Department, University of Medicine and Pharmacy Iuliu Hatieganu, Cluj-Napoca, Romania."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikolaos","family":"Strepis","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology and Infectious Diseases, Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corn\u00e9 H.W.","family":"Klaassen","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology and Infectious Diseases, Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wil H.F.","family":"Goessens","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology and Infectious Diseases, Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2022,6,10]]},"reference":[{"key":"e_1_3_5_2_2","unstructured":"World Health Organization (WHO). 2017. Global priority list of antibiotic-resistant bacteria to guide research discovery and development of new antibiotics. WHO Geneva."},{"key":"e_1_3_5_3_2","doi-asserted-by":"publisher","DOI":"10.1186\/cc5911"},{"key":"e_1_3_5_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhin.2019.09.021"},{"key":"e_1_3_5_5_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00058-16"},{"key":"e_1_3_5_6_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00058-07"},{"key":"e_1_3_5_7_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid1301.060716"},{"key":"e_1_3_5_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2012.09.008"},{"key":"e_1_3_5_9_2","unstructured":"European Centre for Disease Prevention and Control (ECDC). 2018. Surveillance atlas of infectious disease-antimicrobial resistance. Available at http:\/\/atlas.ecdc.europa.eu\/public\/index.aspx%0Ahttps:\/\/atlas.ecdc.europa.eu\/public\/index.aspx (accessed October31 2021)."},{"key":"e_1_3_5_10_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02412-14"},{"key":"e_1_3_5_11_2","doi-asserted-by":"publisher","DOI":"10.1089\/mdr.2018.0036"},{"key":"e_1_3_5_12_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.43.9.4382-4390.2005"},{"key":"e_1_3_5_13_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0010034"},{"key":"e_1_3_5_14_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2019.00930"},{"key":"e_1_3_5_15_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0179228"},{"key":"e_1_3_5_16_2","doi-asserted-by":"crossref","unstructured":"Jolley K.A. Bray J.E and Maiden M.C.J. 2018. Open-access bacterial population genomics: BIGSdb software the PubMLST.org website and their applications. Wellcome Open Res. 3:124.","DOI":"10.12688\/wellcomeopenres.14826.1"},{"key":"e_1_3_5_17_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13756-020-00769-8"},{"key":"e_1_3_5_18_2","doi-asserted-by":"publisher","DOI":"10.1089\/mdr.2016.0190"},{"key":"e_1_3_5_19_2","doi-asserted-by":"publisher","DOI":"10.1089\/mdr.2016.0059"},{"key":"e_1_3_5_20_2","volume-title":"et al","author":"Lowe M.","unstructured":"Lowe M., , Ehlers M.M, , Ismail F., et al. 2018. Acinetobacter baumannii: epidemiological and beta-lactamase data from two tertiary academic hospitals in Tshwane, South Africa. Front. Microbiol. 9:, 1280."},{"key":"e_1_3_5_21_2","first-page":"e00934","volume":"5","author":"Makke G.","year":"2020","unstructured":"Makke G., , Bitar I., , Salloum T., et al. 2020. 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