{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T18:41:23Z","timestamp":1788288083204,"version":"build-2803163510"},"reference-count":33,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Microbial Drug Resistance"],"published-print":{"date-parts":[[2022,5,1]]},"abstract":"<jats:p>\n                    Bacterial and fungal coinfections have posed great clinical challenges in recent years, and combination therapy may be a useful way to treat these mixed infections. The objective of this study was to find an effective drug combination to treat dual-species cultures of fungi and bacteria. In this study, we focused on poorly investigated mixed cultures of\n                    <jats:italic toggle=\"yes\">Candida albicans<\/jats:italic>\n                    and\n                    <jats:italic toggle=\"yes\">Staphylococcus epidermidis<\/jats:italic>\n                    . In this research, we investigated the effects of fluconazole (FLC) and doxycycline (DOX) against dual-species cultures of\n                    <jats:italic toggle=\"yes\">C. albicans<\/jats:italic>\n                    and\n                    <jats:italic toggle=\"yes\">S. epidermidis.<\/jats:italic>\n                    Both the fractional inhibitory concentration index model and \u0394\n                    <jats:italic toggle=\"yes\">E<\/jats:italic>\n                    model revealed a synergistic antimicrobial effect between FLC and DOX against the four groups of dual-species cultures. Mechanistic studies revealed that the synergism of FLC and DOX against dual-species cultures may be associated with the inhibition of biofilms and calcium dysregulation. Fluconazole+doxycycline appears to be a potential drug combination for the treatment of bacterial and fungal coinfections. These findings are of great significance for overcoming clinical bacterial and fungal coinfections and might provide novel insights into drug discovery for combination therapy.\n                  <\/jats:p>","DOI":"10.1089\/mdr.2021.0301","type":"journal-article","created":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T13:26:27Z","timestamp":1648819587000},"page":"525-535","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Synergistic Effects of Fluconazole Combined with Doxycycline Against Dual-Species Cultures of\n                    <i>Candida albicans<\/i>\n                    and\n                    <i>Staphylococcus epidermidis<\/i>\n                    and the Mechanisms of Action"],"prefix":"10.1177","volume":"28","author":[{"given":"Yuan","family":"Gao","sequence":"first","affiliation":[{"name":"Department of Pharmacy, The First Affiliated Hospital of Soochow University, Suzhou, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zihe","family":"Zhang","sequence":"additional","affiliation":[{"name":"Otorhinolaryngologic Department, Shandong Provincial Maternal and Child Health Care Hospital, Jinan, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhicai","family":"Lun","sequence":"additional","affiliation":[{"name":"Pharmacy Department, Juxian Hospital of Traditional Chinese Medicine, Rizhao, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liping","family":"Gong","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynecology Department, Yicheng Street Community Health Service Center, Linyi, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anran","family":"Xu","sequence":"additional","affiliation":[{"name":"Center for Reproductive Medicine, Shandong Provincial Maternal and Child Health Care Hospital, Jinan, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiuyun","family":"Li","sequence":"additional","affiliation":[{"name":"Key Laboratory of Birth Regulation and Control Technology of National Health Commission of China, Shandong Provincial Maternal and Child Health Care Hospital, Jinan, China."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2022,5,17]]},"reference":[{"key":"e_1_3_7_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-6968.2009.01668.x"},{"key":"e_1_3_7_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0966-842X(02)00002-1"},{"key":"e_1_3_7_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.diagmicrobio.2007.07.001"},{"key":"e_1_3_7_5_2","doi-asserted-by":"publisher","DOI":"10.1099\/mic.0.083485-0"},{"key":"e_1_3_7_6_2","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-51-4-344"},{"key":"e_1_3_7_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2012.03906.x"},{"key":"e_1_3_7_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkt099"},{"key":"e_1_3_7_9_2","volume-title":"Candida albicans","author":"Carolus H.","unstructured":"Carolus H., , Van Dyck K., , and Van Dijck P.. 2019. Candida albicans. and Staphylococcus Species: a Threatening Twosome. Front. Microbiol. 10:, 2162."},{"key":"e_1_3_7_10_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-020-05536-z"},{"key":"e_1_3_7_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2005.12.009"},{"key":"e_1_3_7_12_2","doi-asserted-by":"publisher","DOI":"10.1099\/jmm.0.072421-0"},{"key":"e_1_3_7_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkg301"},{"key":"e_1_3_7_14_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dku374"},{"key":"e_1_3_7_15_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.41.4.850"},{"key":"e_1_3_7_16_2","first-page":"1256","article-title":"Synergistic antimicrobial combination of carvacrol and thymol impairs single and mixed-species biofilms of Candida albicans and Staphylococcus epidermidis","volume":"36","author":"Swetha T.K.","year":"2020","unstructured":"Swetha T.K., , Vikraman A., , Nithya C., , Hari Prasath N., , and SK Pandian. 2020. Synergistic antimicrobial combination of carvacrol and thymol impairs single and mixed-species biofilms of Candida albicans and Staphylococcus epidermidis. 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