{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T19:32:20Z","timestamp":1777923140076,"version":"3.51.4"},"reference-count":21,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Microbial Drug Resistance"],"published-print":{"date-parts":[[2022,6,1]]},"abstract":"<jats:p>\n                    We aimed to assess the factors associated with 30-day mortality in patients with vancomycin-resistant\n                    <jats:italic toggle=\"yes\">Enterococcus faecium<\/jats:italic>\n                    (VREf) bloodstream infection (BSI) who received treatment with linezolid in an 11-year retrospective cohort of patients with VREf BSI. A univariate and stepwise multivariate logistic regression analysis was performed to determine 30-day mortality factors. Moreover, a Cox proportional hazards analysis of predictor covariates of mortality was performed. Eighty patients were included in the final analysis; 42 (53%) died and 38 (47%) survived 30 days after the index bacteremia. Thirteen patients of 42 (31%) died in the first 7 days. The Acute Physiology and Chronic Health Evaluation II (APACHE II) score was significantly associated with 30-day mortality (adjusted odds ratio [aOR], 1.46; 95% confidence interval [CI]: 1.22\u20131.76;\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009&lt;\u20090.001) in the multivariate analysis. Moreover, VREf BSI persisting for more than 48 hours was a strong factor related to 30-day mortality (aOR, 19.6; 95% CI: 1.46\u2013263;\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009=\u20090.01). Adequate control of infection source showed a trend to be protective without reaching significance in the multivariate analysis (aOR, 0.19; 95% CI: 0.04\u20131.0;\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009=\u20090.05). The Cox proportional hazards analysis confirmed the same significant mortality predictor besides linezolid treatment within the first 48 hours as a protective factor (hazard ratio 0.46; 95% CI: 0.23\u20130.92,\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009=\u20090.02). Severely ill patients with high APACHE II score and persistent bacteremia have a higher risk of failure with linezolid therapy.\n                  <\/jats:p>","DOI":"10.1089\/mdr.2021.0333","type":"journal-article","created":{"date-parts":[[2022,3,25]],"date-time":"2022-03-25T16:30:56Z","timestamp":1648225856000},"page":"744-749","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":7,"title":["Risk Factors Associated with Failure of Linezolid Therapy in Vancomycin-Resistant\n                    <i>Enterococcus faecium<\/i>\n                    Bacteremia: A Retrospective Cohort Study in a Referral Center in Mexico"],"prefix":"10.1177","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1242-1059","authenticated-orcid":false,"given":"Bruno Ali","family":"Lopez-Luis","sequence":"first","affiliation":[{"name":"Laboratory of Clinical Microbiology, Department of Infectious Diseases, Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n, Mexico City, Mexico."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alfredo","family":"Ponce-De-Le\u00f3n","sequence":"additional","affiliation":[{"name":"Laboratory of Clinical Microbiology, Department of Infectious Diseases, Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n, Mexico City, Mexico."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edgar","family":"Ortiz-Brizuela","sequence":"additional","affiliation":[{"name":"Laboratory of Clinical Microbiology, Department of Infectious Diseases, Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n, Mexico City, Mexico."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Darwin","family":"Lambra\u00f1o-Castillo","sequence":"additional","affiliation":[{"name":"Laboratory of Clinical Microbiology, Department of Infectious Diseases, Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n, Mexico City, Mexico."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisco Javier","family":"Leal-Vega","sequence":"additional","affiliation":[{"name":"Laboratory of Clinical Microbiology, Department of Infectious Diseases, Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n, Mexico City, Mexico."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanet Estrella","family":"Tovar-Calder\u00f3n","sequence":"additional","affiliation":[{"name":"Laboratory of Clinical Microbiology, Department of Infectious Diseases, Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n, Mexico City, Mexico."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miriam","family":"Bobadilla-Del-Valle","sequence":"additional","affiliation":[{"name":"Laboratory of Clinical Microbiology, Department of Infectious Diseases, Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n, Mexico City, Mexico."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9","family":"Sifuentes-Osornio","sequence":"additional","affiliation":[{"name":"Department of Medicine, Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n, Mexico City, Mexico."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2022,6,10]]},"reference":[{"key":"e_1_3_4_2_2","first-page":"32","article-title":"The Enterococcus: a model of adaptability to its environment","volume":"30","author":"Garc\u00eda-Solache M.","year":"2019","unstructured":"Garc\u00eda-Solache M., , and Rice L.B.. 2019. The Enterococcus: a model of adaptability to its environment. Clin. Microbiol. Rev. 30:32.","journal-title":"Clin. Microbiol. Rev"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1017\/ice.2016.174"},{"key":"e_1_3_4_4_2","first-page":"Sweden","article-title":"Point prevalence survey of healthcare-associated infections and antimicrobial use in European acute care hospitals 2011\u20132012","author":"European Centre for Disease Prevention and Control","year":"2013","unstructured":"European Centre for Disease Prevention and Control. 2013. Point prevalence survey of healthcare-associated infections and antimicrobial use in European acute care hospitals 2011\u20132012. European Centre for Disease Prevention and Control,, Solna, Sweden.","journal-title":"European Centre for Disease Prevention and Control,"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1017\/ice.2015.228"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1017\/ice.2016.254"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciw110"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000003325"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00714-13"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01289-13"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-014-0687-9"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/civ444"},{"key":"e_1_3_4_13_2","unstructured":"National Healthcare Safety Network (NHSN). 2021. Identifying healthcare-associated infections (HAI) for NHSN surveillance. US Centers for Disease Control and Prevention (CDC). Available at https:\/\/www.cdc.gov\/nhsn\/pdfs\/pscmanual\/2psc_identifyinghais_nhsncurrent.pdf (accessed August11 2021)."},{"key":"e_1_3_4_14_2","unstructured":"Clinical and Laboratory Standards Institute (CLSI). 2021. Performance Standards for Antimicrobial Susceptibility Testing. 31st ed. CLSI Supplement M100. Clinical and Laboratory Standards Institute Wayne PA."},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02216-16"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jgar.2019.10.008"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/phar.1393"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000003264"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dku379"},{"key":"e_1_3_4_20_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cix1127"},{"key":"e_1_3_4_21_2","doi-asserted-by":"publisher","DOI":"10.1186\/cc13984"},{"key":"e_1_3_4_22_2","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofaa064"}],"container-title":["Microbial Drug Resistance"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1089\/mdr.2021.0333","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/mdr.2021.0333","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/mdr.2021.0333","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T20:39:59Z","timestamp":1777667999000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1089\/mdr.2021.0333"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6,1]]},"references-count":21,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2022,6,1]]}},"alternative-id":["10.1089\/mdr.2021.0333"],"URL":"https:\/\/doi.org\/10.1089\/mdr.2021.0333","relation":{},"ISSN":["1076-6294","1931-8448"],"issn-type":[{"value":"1076-6294","type":"print"},{"value":"1931-8448","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,6,1]]}}}