{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T15:49:37Z","timestamp":1787759377801,"version":"build-2784847793"},"reference-count":49,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Microbial Drug Resistance"],"published-print":{"date-parts":[[2022,6,1]]},"abstract":"<jats:p>\n                    Healthcare-associated carbapenem-resistant\n                    <jats:italic toggle=\"yes\">Acinetobacter baumannii<\/jats:italic>\n                    (CRAB) infections are a serious threat associated with global epidemic clones and a variety of carbapenemase gene classes. In this study, we describe the molecular epidemiology, including whole-genome sequencing analysis and antimicrobial susceptibility profiles of 92 selected, nonredundant CRAB collected through public health efforts in the United States from 2013 to 2017. Among the 92 isolates, the Oxford (OX) multilocus sequence typing scheme identified 30 sequence types (STs); the majority of isolates (\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    \u2009=\u200959, 64%) represented STs belonging to the international clonal complex 92 (CC92\n                    <jats:sub>OX<\/jats:sub>\n                    ). Among these, ST208\n                    <jats:sub>OX<\/jats:sub>\n                    (\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    \u2009=\u200921) and ST281\n                    <jats:sub>OX<\/jats:sub>\n                    (\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    \u2009=\u200920) were the most common. All isolates carried an OXA-type carbapenemase gene, comprising 20 alleles. Ninety isolates (98%) encoded an intrinsic OXA-51-like enzyme; 67 (73%) harbored an additional acquired\n                    <jats:italic toggle=\"yes\">bla<\/jats:italic>\n                    <jats:sub>OXA<\/jats:sub>\n                    gene, most commonly\n                    <jats:italic toggle=\"yes\">bla<\/jats:italic>\n                    <jats:sub>OXA-23<\/jats:sub>\n                    (\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    \u2009=\u200945; 49%).\n                  <\/jats:p>\n                  <jats:p>\n                    Compared with isolates harboring only intrinsic oxacillinase genes, acquired\n                    <jats:italic toggle=\"yes\">bla<\/jats:italic>\n                    <jats:sub>OXA<\/jats:sub>\n                    gene presence was associated with higher prevalence of resistance and a higher median minimum inhibitory concentration to the carbapenem imipenem (64\u2009\u03bcg\/mL vs. 8\u2009\u03bcg\/mL), and antibiotics from other drug classes, including penicillin, aminoglycosides, cephalosporins, and polymyxins. These data illustrate the wide distribution of CC92\n                    <jats:sub>OX<\/jats:sub>\n                    and high prevalence of acquired\n                    <jats:italic toggle=\"yes\">bla<\/jats:italic>\n                    <jats:sub>OXA<\/jats:sub>\n                    carbapenemase genes among CRAB in the United States.\n                  <\/jats:p>","DOI":"10.1089\/mdr.2021.0352","type":"journal-article","created":{"date-parts":[[2022,5,31]],"date-time":"2022-05-31T11:02:43Z","timestamp":1653994963000},"page":"645-653","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":29,"title":["Molecular Epidemiology of Carbapenem-Resistant\n                    <i>Acinetobacter baumannii<\/i>\n                    in the United States, 2013\u20132017"],"prefix":"10.1177","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2318-5189","authenticated-orcid":false,"given":"Susannah L.","family":"McKay","sequence":"first","affiliation":[{"name":"Division of Healthcare Quality Promotion, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas","family":"Vlachos","sequence":"additional","affiliation":[{"name":"Division of Healthcare Quality Promotion, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan B.","family":"Daniels","sequence":"additional","affiliation":[{"name":"Division of Healthcare Quality Promotion, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valerie S.","family":"Albrecht","sequence":"additional","affiliation":[{"name":"Division of Healthcare Quality Promotion, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valerie A.","family":"Stevens","sequence":"additional","affiliation":[{"name":"Division of Healthcare Quality Promotion, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. Kamile","family":"Rasheed","sequence":"additional","affiliation":[{"name":"Division of Healthcare Quality Promotion, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. Kristie","family":"Johnson","sequence":"additional","affiliation":[{"name":"Department of Pathology and University of Maryland School of Medicine, Baltimore, Maryland, USA."},{"name":"Department of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, Maryland, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph D.","family":"Lutgring","sequence":"additional","affiliation":[{"name":"Division of Healthcare Quality Promotion, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Sj\u00f6lund-Karlsson","sequence":"additional","affiliation":[{"name":"Division of Healthcare Quality Promotion, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alison Laufer","family":"Halpin","sequence":"additional","affiliation":[{"name":"Division of Healthcare Quality Promotion, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2022,6,10]]},"reference":[{"key":"e_1_3_6_2_2","first-page":"and","article-title":"Acinetobacter spp","author":"Bergogne-Berezin E.","year":"1996","unstructured":"Bergogne-Berezin E., , and Towner K.J.. 1996. Acinetobacter spp. as nosocomial pathogens: microbiological,, clinical, and epidemiological features. Clin. Microbiol. Rev. 9:148\u2013165.","journal-title":"as nosocomial pathogens: microbiological,"},{"key":"e_1_3_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(08)70279-2"},{"key":"e_1_3_6_4_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2044.2003.30403.x"},{"key":"e_1_3_6_5_2","unstructured":"CDC. 2021. Antibiotic resistance & patient safety portal: Carbapenem-resistant Acinetobacter. Available at https:\/\/arpsp.cdc.gov\/profile\/antibiotic-resistance\/carbapenem-resistant-acinetobacter (accessed October4 2021)."},{"key":"e_1_3_6_6_2","unstructured":"CDC. 2019. Antibiotic resistance threats in the United States 2019. 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