{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T15:47:47Z","timestamp":1779378467511,"version":"3.53.1"},"reference-count":41,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Microbial Drug Resistance"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:p>\n                    The study describes the first isolation of multidrug-resistant (MDR)\n                    <jats:italic toggle=\"yes\">Klebsiella pneumoniae<\/jats:italic>\n                    ST16,\n                    <jats:italic toggle=\"yes\">Escherichia coli<\/jats:italic>\n                    ST131 (Esc), and\n                    <jats:italic toggle=\"yes\">Enterobacter hormaechei<\/jats:italic>\n                    subsp. steigerwaltii ST93 (\n                    <jats:italic toggle=\"yes\">Enterobacter cloacae<\/jats:italic>\n                    complex [ECC]) in Sri Lanka. Eight MDR strains of uropathogenic Enterobacterales isolated from hospital acquired urinary tract infections (UTIs) were analyzed using genomic sequencing and comparative genomics. Isolates carried multiple carbapenemase, AmpC, and ESBL (extended-spectrum \u03b2-lactamase) genes. ECC manifested both\n                    <jats:italic toggle=\"yes\">bla<\/jats:italic>\n                    <jats:sub>NDM-4<\/jats:sub>\n                    and\n                    <jats:italic toggle=\"yes\">bla<\/jats:italic>\n                    <jats:sub>OXA-181<\/jats:sub>\n                    . The\n                    <jats:italic toggle=\"yes\">K. pneumoniae<\/jats:italic>\n                    strains harbored fimbrial genes that facilitate pathogenesis of UTI. Several extraintestinal pathogenic\n                    <jats:italic toggle=\"yes\">E. coli<\/jats:italic>\n                    associated virulence genes were identified in Esc. The efflux pump gene,\n                    <jats:italic toggle=\"yes\">acrA<\/jats:italic>\n                    , and the T6SS gene cluster were detected in ECC. Many antimicrobial resistance (AMR) and virulence genes were identified associated with mobile genetic elements. ISEcp1 flanked upstream of\n                    <jats:italic toggle=\"yes\">bla<\/jats:italic>\n                    <jats:sub>CTX-M-15<\/jats:sub>\n                    . The carbapenemase genes were carried on ColKP3 plasmids and were associated with ISEcp1. In Esc, the AMR gene\n                    <jats:italic toggle=\"yes\">bla<\/jats:italic>\n                    <jats:sub>TEM-1B<\/jats:sub>\n                    and virulence gene\n                    <jats:italic toggle=\"yes\">traT<\/jats:italic>\n                    were found on an IncF plasmid replicon. In\n                    <jats:italic toggle=\"yes\">K. pneumoniae<\/jats:italic>\n                    the AMR genes\n                    <jats:italic toggle=\"yes\">sul1<\/jats:italic>\n                    and tetB present on IncR plasmid replicons and were associated with the insertion sequence IS6100. In Kp5,\n                    <jats:italic toggle=\"yes\">bla<\/jats:italic>\n                    <jats:sub>LAP-2<\/jats:sub>\n                    and\n                    <jats:italic toggle=\"yes\">qnrS1<\/jats:italic>\n                    coexisted and were flanked by ISEcl. AMR gene clusters, conferring resistance to multiple antimicrobial classes, flanked by mobile elements were identified in seven isolates.\n                  <\/jats:p>","DOI":"10.1089\/mdr.2022.0003","type":"journal-article","created":{"date-parts":[[2022,8,16]],"date-time":"2022-08-16T11:40:25Z","timestamp":1660650025000},"page":"882-892","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":7,"title":["Antimicrobial Resistance Genes, Virulence Genes, and Associated Mobile Genetic Elements of Eight Multidrug-Resistant\n                    <i>Enterobacterales<\/i>\n                    Isolated from Hospital-Acquired Urinary Tract Infections in Sri Lanka"],"prefix":"10.1177","volume":"28","author":[{"given":"Vindya","family":"Perera","sequence":"first","affiliation":[{"name":"Department of Microbiology, Faculty of Medicine, University of Colombo, Colombo, Sri Lanka."},{"name":"Department of Microbiology, Faculty of Medicine, Sabaragamuwa University of Sri Lanka, Ratnapura, Sri Lanka."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"de Silva","sequence":"additional","affiliation":[{"name":"Sri Jayewardenepura General Hospital, Nugegoda, Sri Lanka."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kushlani","family":"Jayatilleke","sequence":"additional","affiliation":[{"name":"Sri Jayewardenepura General Hospital, Nugegoda, Sri Lanka."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nelun","family":"de Silva","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Faculty of Medicine, Sabaragamuwa University of Sri Lanka, Ratnapura, Sri Lanka."},{"name":"Neville Fernando Teaching Hospital, Malabe, Sri Lanka."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alp","family":"Aydin","sequence":"additional","affiliation":[{"name":"Centre for Clinical Microbiology, Division of Infection and Immunity, University College London, Royal Free Campus, Rowland Hill Street, London, United Kingdom."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virve","family":"Enne","sequence":"additional","affiliation":[{"name":"Centre for Clinical Microbiology, Division of Infection and Immunity, University College London, Royal Free Campus, Rowland Hill Street, London, United Kingdom."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enoka","family":"Corea","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Faculty of Medicine, University of Colombo, Colombo, Sri Lanka."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2022,8,16]]},"reference":[{"issue":"2","key":"e_1_3_3_2_2","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.jiph.2019.07.025","volume":"13","author":"Neubeiser A","year":"2020","unstructured":"Neubeiser A, , Bonsignore M, , Tafelski S, et al. 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