{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T19:32:29Z","timestamp":1777923149454,"version":"3.51.4"},"reference-count":47,"publisher":"SAGE Publications","issue":"11","license":[{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Microbial Drug Resistance"],"published-print":{"date-parts":[[2022,11]]},"abstract":"\n Background:<\/jats:title>\n \n Extensive use of carbapenems to treat multidrug-resistant (MDR) Gram-negative bacteria (GNB) facilitates the wide dissemination of carbapenemase-producing carbapenem-resistant GNB. Colistin was reintroduced into clinical settings to manage these GNB infections. However, there is currently an increase in the dissemination of mobile colistin resistance (\n mcr)<\/jats:italic>\n -producing colistin-resistant GNB isolates in clinical settings. The epidemiology of carbapenemases and\n mcr<\/jats:italic>\n in Pretoria was evaluated.\n <\/jats:p>\n <\/jats:sec>\n \n Methods:<\/jats:title>\n \n Clinical MDR GNB were collected and screened for carbapenemases and\n mcr<\/jats:italic>\n using polymerase chain reaction (PCR); their antibiotic susceptibility profiles were elucidated using the Vitek\n \u00ae<\/jats:sup>\n 2 automated system (Biomerieux, France) and microbroth dilution (for colistin).\n <\/jats:p>\n <\/jats:sec>\n \n Results and Discussion:<\/jats:title>\n \n A total of 306 isolates were collected; a majority of these were\n Klebsiella pneumoniae<\/jats:italic>\n (\n n<\/jats:italic>\n \u2009=\u2009208) and were collected from males (\n n<\/jats:italic>\n \u2009=\u2009158). The isolates were retrieved from a variety of infection sites, including urine, blood cultures, and rectal swabs. The Vitek 2 system found that these isolates were largely resistant to \u03b2-lactams, where 217 (70.9%) had reduced susceptibility to at least one carbapenem (ertapenem, meropenem, or imipenem), and 81 isolates (26.5%) were resistant to colistin. PCR screening identified 201 (65.7%) isolates harboring carbapenemase genes consisting of\n bla<\/jats:italic>\n OXA-48<\/jats:sub>\n (170, 84.2%),\n bla<\/jats:italic>\n NDM<\/jats:sub>\n (31, 15.4%),\n bla<\/jats:italic>\n IMP<\/jats:sub>\n (5, 2%),\n bla<\/jats:italic>\n KPC<\/jats:sub>\n (4, 1%), and\n bla<\/jats:italic>\n VIM<\/jats:sub>\n (5, 2%). Furthermore, 14\n bla<\/jats:italic>\n OXA-48<\/jats:sub>\n \u2013producing isolates were coharboring\n bla<\/jats:italic>\n VIM<\/jats:sub>\n (2),\n bla<\/jats:italic>\n NDM<\/jats:sub>\n (9),\n bla<\/jats:italic>\n KPC<\/jats:sub>\n (1), and\n bla<\/jats:italic>\n IMP<\/jats:sub>\n (2) genes. Only one isolate harbored the mobile colistin resistance (\n mcr<\/jats:italic>\n )\n -1<\/jats:italic>\n gene, and this is the first report of an\n mcr-1<\/jats:italic>\n \u2013producing\n Acinetobacter baumannii<\/jats:italic>\n isolate in South Africa.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n \n There is high endemicity of carbapenemase genes and a low prevalence of\n mcr<\/jats:italic>\n genes in GNB, particularly in\n K. pneumoniae,<\/jats:italic>\n in health care facilities in Pretoria and surrounding regions of South Africa.\n <\/jats:p>\n <\/jats:sec>\n \n Significance:<\/jats:title>\n Health care facilities in Pretoria are becoming breeding grounds for MDR infections that threaten public health. Careful use of carbapenems and other antibiotics is necessary to prevent further escalation and outbreak of these MDR strains that can claim several lives.<\/jats:p>\n <\/jats:sec>","DOI":"10.1089\/mdr.2022.0112","type":"journal-article","created":{"date-parts":[[2022,10,17]],"date-time":"2022-10-17T14:32:02Z","timestamp":1666017122000},"page":"1028-1036","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":12,"title":["Molecular Screening of Clinical Multidrug-Resistant Gram-Negative Bacteria Shows Endemicity of Carbapenemases, Coexistence of Multiple Carbapenemases, and Rarity of\n mcr<\/i>\n in South Africa"],"prefix":"10.1177","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5238-454X","authenticated-orcid":false,"given":"Masego","family":"Mmatli","sequence":"first","affiliation":[{"name":"Department of Medical Microbiology, School of Medicine, University of Pretoria, Pretoria, South Africa."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tumisho Mmatumelo Seipei","family":"Leshaba","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology, School of Medicine, University of Pretoria, Pretoria, South Africa."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lebogang B.","family":"Skosana","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology, School of Medicine, University of Pretoria, Pretoria, South Africa."},{"name":"Tshwane Academic Division, Department of Medical Microbiology, National Health Laboratory Service, Pretoria, South Africa."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nontombi Marylucy","family":"Mbelle","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology, School of Medicine, University of Pretoria, Pretoria, South Africa."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9508-984X","authenticated-orcid":false,"given":"John","family":"Osei Sekyere","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology, School of Medicine, University of Pretoria, Pretoria, South Africa."},{"name":"Department of Dermatology, School of Medicine, University of Pretoria, Pretoria, South Africa."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2022,11,14]]},"reference":[{"key":"e_1_3_6_2_2","doi-asserted-by":"crossref","first-page":"8654","DOI":"10.3390\/ijms21228654","article-title":"New bacteriocins from Lacticaseibacillus paracasei CNCM I-5369 adsorbed on alginate nanoparticles are very active against Escherichia coli","volume":"21","author":"Belguesmia Y","year":"2022","unstructured":"Belguesmia Y, , Hazime N, , Kempf I, et al. New bacteriocins from Lacticaseibacillus paracasei CNCM I-5369 adsorbed on alginate nanoparticles are very active against Escherichia coli. Int J Mol Sci, 2022; 21:8654.","journal-title":"Int J Mol Sci"},{"key":"e_1_3_6_3_2","first-page":"e02881","article-title":"Colistin heteroresistance is largely undetected among carbapenem-resistant enterobacterales in the United States","volume":"12","author":"Band VI","year":"2021","unstructured":"Band VI, , Satola SW, , Smith RD, et al. Colistin heteroresistance is largely undetected among carbapenem-resistant enterobacterales in the United States. 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