{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T15:58:38Z","timestamp":1791388718093,"version":"4.3.3"},"reference-count":42,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Microbial Drug Resistance"],"published-print":{"date-parts":[[2023,3,1]]},"abstract":"<jats:p>\n                    Turkey presents both a high prevalence of\n                    <jats:italic toggle=\"yes\">Helicobacter pylori<\/jats:italic>\n                    infection and high prevalence of antibiotic resistance. In this study, we aimed to summarize recent data on\n                    <jats:italic toggle=\"yes\">H. pylori<\/jats:italic>\n                    antibiotic resistance rates in this nation. After conducting searches in two national and international databases (ULAKBIM, EKUAL, and PubMed), a systematic review was conducted. A total of 197 original articles on antibiotic resistance of\n                    <jats:italic toggle=\"yes\">H. pylori<\/jats:italic>\n                    in Turkey were collected. After screening for inclusion and exclusion criteria, to evaluate the\n                    <jats:italic toggle=\"yes\">H. pylori<\/jats:italic>\n                    antibiotic resistance for the period 2005\u20132020, 20 eligible articles were included in the meta-analysis. Data analysis was performed using MedCalc 12.7.0. The number of isolated\n                    <jats:italic toggle=\"yes\">H. pylori<\/jats:italic>\n                    strains in each study was weighted, and pooled proportion analysis was performed. This review included 20 Turkish studies, including 1,556\n                    <jats:italic toggle=\"yes\">H. pylori<\/jats:italic>\n                    strains. The overall resistance rates were as follows: clarithromycin (CLA), 26.7% (95% confidence interval [CI]: 20.5\u201333.5); metronidazole (MTZ), 28.4% (95% CI: 19.7\u201338.1); levofloxacin (LVX), 19.6% (95% CI: 9.9\u201331.7); tetracycline (TET), 0.7% (95% CI: 0.1\u20131.8); and amoxicillin (AMO), 1.3% (95% CI: 0.3\u20133.1). The reported results showed that Turkish\n                    <jats:italic toggle=\"yes\">H. pylori<\/jats:italic>\n                    isolates are highly resistant to CLA, MTZ, and LVX, while exhibiting a low level of resistance toward AMO and TET.\n                  <\/jats:p>","DOI":"10.1089\/mdr.2022.0146","type":"journal-article","created":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T14:27:22Z","timestamp":1675261642000},"page":"96-103","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":12,"title":["Antibiotic Resistance of\n                    <i>Helicobacter pylori<\/i>\n                    in Turkey: A Systematic Review and Meta-Analysis"],"prefix":"10.1177","volume":"29","author":[{"given":"Meltem","family":"Aya\u015f","sequence":"first","affiliation":[{"name":"Department of Medical Biotechnology, Institute of Health Sciences, Acibadem Mehmet Ali Aydinlar University, Istanbul, Turkey."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ye\u015fim","family":"G\u00fcrol","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology, School of Medicine, Acibadem Mehmet Ali Aydinlar University, Istanbul, Turkey."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2023,3,16]]},"reference":[{"key":"e_1_3_4_2_2","first-page":"1","article-title":"Schistosomes, liver flukes and Helicobacter pylori","volume":"61","author":"Working Group on the Evaluation of Carcinogenic Risks to Humans ARC","year":"1994","unstructured":"IWorking Group on the Evaluation of Carcinogenic Risks to Humans ARC. 1994. 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