{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T19:32:45Z","timestamp":1777923165053,"version":"3.51.4"},"reference-count":22,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T00:00:00Z","timestamp":1693180800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Microbial Drug Resistance"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>\n                      Infections caused by carbapenem-resistant\n                      <jats:italic toggle=\"yes\">Klebsiella pneumoniae<\/jats:italic>\n                      (CR-KP) are an important public health problem. This study aimed to evaluate the clinical characteristics of patients with CR-KP.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>A retrospective cohort study was conducted of all patients with CR-KP infection. A total of 615 patients with CR-KP infection were identified and 135 patients who did not meet the eligibility criteria were excluded. Clinical characteristics, antimicrobial regimens, and patient outcomes were analyzed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>The overall mortality rate of CR-KP infections was 37.3% and the mortality rate in patients with bloodstream infections was 66.2%. Survival analysis revealed that there were statistically significant differences between patients with bloodstream infections and those with pulmonary and drainage fluid infections. Logistics regression analysis showed that hemopathy, age &gt;60 years, solid tumors, diabetes, septic shock, acute kidney injury, and stroke were independent predictors of 30-day mortality rate. The chi-square test showed that treatment with a combination of carbapenems, tigecycline, and polymyxin B was superior to treatment with carbapenems with polymyxin B, without tigecycline.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>CR-KP infections, especially bloodstream infections, have a high mortality rate. The outcome is strongly dependent on patients' clinical conditions. Antimicrobial regimens combining carbapenems, tigecycline, and polymyxin B might be a better choice.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/mdr.2022.0280","type":"journal-article","created":{"date-parts":[[2023,5,15]],"date-time":"2023-05-15T11:29:54Z","timestamp":1684150194000},"page":"401-406","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Clinical and Epidemiological Characteristics of Carbapenem-Resistant\n                    <i>Klebsiella pneumoniae<\/i>\n                    Infections in a Tertiary Hospital in China"],"prefix":"10.1177","volume":"29","author":[{"given":"Zhiwen","family":"Cui","sequence":"first","affiliation":[{"name":"Intensive Care Unit, The First Affiliated Hospital of Zhengzhou University, Henan, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lirui","family":"Wang","sequence":"additional","affiliation":[{"name":"Intensive Care Unit, The First Affiliated Hospital of Zhengzhou University, Henan, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min","family":"Feng","sequence":"additional","affiliation":[{"name":"Intensive Care Unit, The First Affiliated Hospital of Zhengzhou University, Henan, China."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2023,8,28]]},"reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid1710.110655"},{"issue":"7","key":"e_1_3_5_3_2","doi-asserted-by":"crossref","first-page":"2133","DOI":"10.1093\/jac\/dkv086","article-title":"Infections caused by KPC-producing Klebsiella pneumoniaee: Differences in therapy and mortality in a multicentre study","volume":"70","author":"Tumbarello M","year":"2015","unstructured":"Tumbarello M, , Trecarichi EM, , De Rosa FG, et al. 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