{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T11:01:01Z","timestamp":1778842861271,"version":"3.51.4"},"reference-count":37,"publisher":"SAGE Publications","issue":"12","license":[{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Microbial Drug Resistance"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:p>\n                    Although many drug-resistant nontyphoidal\n                    <jats:italic toggle=\"yes\">Salmonella<\/jats:italic>\n                    (NTS) infections are reported globally, their treatment is challenging owing to the ineffectiveness of the currently available antimicrobial drugs against resistant bacteria. It is therefore essential to discover novel antimicrobial drugs for the management of these infections. In this study, we report high inhibitory activities of the novel fluoroquinolones (FQs; WQ-3810 and WQ-3334) with substitutions at positions R-1 by 6-amino-3,5-difluoropyridine-2-yl and R-8 by methyl group or bromine, respectively, against wild-type and mutant DNA gyrases of\n                    <jats:italic toggle=\"yes\">Salmonella<\/jats:italic>\n                    Typhimurium. The inhibitory activities of these FQs were assessed against seven amino acid substitutions in DNA gyrases conferring FQ resistance to\n                    <jats:italic toggle=\"yes\">S.<\/jats:italic>\n                    Typhimurium, including high-level resistant mutants, Ser83Ile and Ser83Phe-Asp87Asn by\n                    <jats:italic toggle=\"yes\">in vitro<\/jats:italic>\n                    DNA supercoiling assay. Drug concentrations of WQ compounds with 6-amino-3,5-difluoropyridine-2-yl that suppressed DNA supercoiling by 50% (IC\n                    <jats:sub>50<\/jats:sub>\n                    ) were found to be \u223c150-fold lower than ciprofloxacin against DNA gyrase with double amino acid substitutions. Our findings highlight the importance of the chemical structure of an FQ drug on its antimicrobial activity. Particularly, the presence of 6-amino-3,5-difluoropyridine-2-yl at R-1 and either methyl group or bromine at R-8 of WQ-3810 and WQ-3334, respectively, was associated with improved antimicrobial activity. Therefore, WQ-3810 and WQ-3334 are promising candidates for use in the treatment of patients infected by FQ-resistant\n                    <jats:italic toggle=\"yes\">Salmonella<\/jats:italic>\n                    spp.\n                  <\/jats:p>","DOI":"10.1089\/mdr.2023.0014","type":"journal-article","created":{"date-parts":[[2023,10,4]],"date-time":"2023-10-04T11:23:57Z","timestamp":1696418637000},"page":"552-560","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["The Impact of Substitutions at Positions 1 and 8 of Fluoroquinolones on the Activity Against Mutant DNA Gyrases of\n                    <i>Salmonella<\/i>\n                    Typhimurium"],"prefix":"10.1177","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2331-0063","authenticated-orcid":false,"given":"Pondpan","family":"Suwanthada","sequence":"first","affiliation":[{"name":"Division of Bioresources, International Institute for Zoonosis Control, Hokkaido University, Sapporo, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siriporn","family":"Kongsoi","sequence":"additional","affiliation":[{"name":"Department of Veterinary Public Health, Faculty of Veterinary Medicine, Kasetsart University, Nakhon Pathom, Thailand."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nami","family":"Miura","sequence":"additional","affiliation":[{"name":"Division of Bioresources, International Institute for Zoonosis Control, Hokkaido University, Sapporo, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lawrence P.","family":"Belotindos","sequence":"additional","affiliation":[{"name":"Division of Bioresources, International Institute for Zoonosis Control, Hokkaido University, Sapporo, Japan."},{"name":"Biosafety and Environment Section, Research for Development Division, Philippine Carabao Center National Headquarters and Gene Pool, Science City of Munoz, Philippines."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chayada","family":"Piantham","sequence":"additional","affiliation":[{"name":"Division of Bioinformatics, International Institute for Zoonosis Control, Hokkaido University, Sapporo, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jirachaya","family":"Toyting","sequence":"additional","affiliation":[{"name":"Division of Bioresources, International Institute for Zoonosis Control, Hokkaido University, Sapporo, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mwangala L.","family":"Akapelwa","sequence":"additional","affiliation":[{"name":"Division of Bioresources, International Institute for Zoonosis Control, Hokkaido University, Sapporo, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruttana","family":"Pachanon","sequence":"additional","affiliation":[{"name":"Division of Bioresources, International Institute for Zoonosis Control, Hokkaido University, Sapporo, Japan."},{"name":"Department of Microbiology, Faculty of Veterinary Science, Chulalongkorn University, Bangkok, Thailand."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9840-3689","authenticated-orcid":false,"given":"Kentaro","family":"Koide","sequence":"additional","affiliation":[{"name":"Division of Bioresources, International Institute for Zoonosis Control, Hokkaido University, Sapporo, Japan."},{"name":"Department of Bacteriology II, National Institute of Infectious Diseases, Musashimurayama, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyun","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Bacteriology II, National Institute of Infectious Diseases, Musashimurayama, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeewan","family":"Thapa","sequence":"additional","affiliation":[{"name":"Division of Bioresources, International Institute for Zoonosis Control, Hokkaido University, Sapporo, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chie","family":"Nakajima","sequence":"additional","affiliation":[{"name":"Division of Bioresources, International Institute for Zoonosis Control, Hokkaido University, Sapporo, Japan."},{"name":"International Collaboration Unit, International Institute for Zoonosis Control, Hokkaido University, Sapporo, Japan."},{"name":"Institute for Vaccine Research and Development: HU-IVRe, Hokkaido University, Sapporo, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuhiko","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Division of Bioresources, International Institute for Zoonosis Control, Hokkaido University, Sapporo, Japan."},{"name":"International Collaboration Unit, International Institute for Zoonosis Control, Hokkaido University, Sapporo, Japan."},{"name":"Institute for Vaccine Research and Development: HU-IVRe, Hokkaido University, Sapporo, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2023,12,8]]},"reference":[{"issue":"12","key":"e_1_3_3_2_2","doi-asserted-by":"crossref","first-page":"1312","DOI":"10.1016\/S1473-3099(19)30418-9","article-title":"The global burden of non-typhoidal salmonella invasive disease: a systematic analysis for the Global Burden of Disease Study 2017","volume":"19","author":"Stanaway JD","year":"2019","unstructured":"Stanaway JD, , Parisi A, , Sarkar K, et al. The global burden of non-typhoidal salmonella invasive disease: a systematic analysis for the Global Burden of Disease Study 2017. Lancet Infect Dis, 2019; 19(12):1312\u20131324; doi: 10.1016\/S1473-3099(19)30418-9","journal-title":"Lancet Infect Dis"},{"key":"e_1_3_3_3_2","volume-title":"WHO Estimates of the Global Burden of Foodborne Diseases: Foodborne Disease Burden Epidemiology Reference Group","author":"World Health Organization","year":"2015","unstructured":"World Health Organization. WHO Estimates of the Global Burden of Foodborne Diseases: Foodborne Disease Burden Epidemiology Reference Group 2007\u20132015; 2015."},{"issue":"8","key":"e_1_3_3_4_2","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1089\/fpd.2010.0787","article-title":"Global monitoring of salmonella serovar distribution from the world health organization global foodborne infections network country data bank: Results of quality assured laboratories from 2001 to 2007","volume":"8","author":"Rene SH","year":"2011","unstructured":"Rene SH, , Vieira AR, , Karlsmose S, et al. Global monitoring of salmonella serovar distribution from the world health organization global foodborne infections network country data bank: Results of quality assured laboratories from 2001 to 2007. Foodborne Pathog Dis;, 2011; 8(8):887\u2013900; doi: 10.1089\/fpd.2010.0787","journal-title":"Foodborne Pathog Dis;"},{"issue":"8","key":"e_1_3_3_5_2","first-page":"1239","article-title":"Outbreak-associated salmonella enterica serotypes and food commodities","volume":"19","author":"Jackson BR","year":"2013","unstructured":"Jackson BR, , Griffin PM, , Cole D, et al. Outbreak-associated salmonella enterica serotypes and food commodities. Emerg Infect Dis, 2013; 19(8):1239\u20131244; doi: 10.3201\/eid1908.121511","journal-title":"Emerg Infect Dis"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1086\/650733"},{"issue":"1","key":"e_1_3_3_7_2","first-page":"1","article-title":"A systematic review of the incidence, risk factors and case fatality rates of invasive nontyphoidal Salmonella (iNTS) disease in Africa (1966 to 2014)","volume":"11","author":"Uche IV","year":"2017","unstructured":"Uche IV, , MacLennan CA, , Saul A. A systematic review of the incidence, risk factors and case fatality rates of invasive nontyphoidal Salmonella (iNTS) disease in Africa (1966 to 2014). PLoS Negl Trop Dis, 2017; 11(1):1\u201328; doi: 10.1371\/journal.pntd.0005118","journal-title":"PLoS Negl Trop Dis"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)61752-2"},{"issue":"10","key":"e_1_3_3_9_2","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1002\/dta.1910","article-title":"Amino acid substitutions in GyrA affect quinolone susceptibility in Salmonella typhimurium","volume":"8","author":"Kongsoi S","year":"2016","unstructured":"Kongsoi S, , Changkwanyeun R, , Yokoyama K, et al. Amino acid substitutions in GyrA affect quinolone susceptibility in Salmonella typhimurium. Drug Test Anal, 2016; 8(10):1065\u20131070; doi: 10.1002\/dta.1910","journal-title":"Drug Test Anal"},{"issue":"9","key":"e_1_3_3_10_2","doi-asserted-by":"crossref","first-page":"a0253","DOI":"10.1101\/cshperspect.a025320","article-title":"Topoisomerase inhibitors: Fluoroquinolone mechanisms of action and resistance","volume":"6","author":"Hooper DC","year":"2016","unstructured":"Hooper DC, , Jacoby GA. Topoisomerase inhibitors: Fluoroquinolone mechanisms of action and resistance. Cold Spring Harb Perspect Med, 2016; 6(9):a0253:1\u201321; doi: 10.1101\/cshperspect.a025320","journal-title":"Cold Spring Harb Perspect Med"},{"issue":"2","key":"e_1_3_3_11_2","article-title":"DNA topoisomerases","volume":"6","author":"Bush NG","year":"2015","unstructured":"Bush NG, , Evans-Rober K, , Maxwell A. DNA topoisomerases. EcoSal Plus, 2015; 6(2):10.11; doi: 10.1128\/ecosalplus.ESP-0010-2014","journal-title":"EcoSal Plus"},{"issue":"8","key":"e_1_3_3_12_2","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1002\/dta.1744","article-title":"Characterization of Salmonella typhimurium DNA gyrase as a target of quinolones","volume":"7","author":"Kongsoi S","year":"2015","unstructured":"Kongsoi S, , Yokoyama K, , Suprasert A, et al. Characterization of Salmonella typhimurium DNA gyrase as a target of quinolones. Drug Test Anal, 2015; 7(8):714\u2013720. doi: 10.1002\/dta.1744","journal-title":"Drug Test Anal"},{"key":"e_1_3_3_13_2","doi-asserted-by":"crossref","unstructured":"CDC. Antibiotic Resistance Threats in the United States. Vol. 10; 2019. doi: 10.1186\/s13756-020-00872-w","DOI":"10.1186\/s13756-020-00872-w"},{"issue":"4","key":"e_1_3_3_14_2","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1016\/j.pedneo.2020.03.017","article-title":"Highly antimicrobial-resistant nontyphoidal Salmonella from retail meats and clinical impact in children, Taiwan","volume":"61","author":"Chang Y-J","year":"2020","unstructured":"Chang Y-J, , Chen M-C, , Feng Y, et al. Highly antimicrobial-resistant nontyphoidal Salmonella from retail meats and clinical impact in children, Taiwan. Pediatr Neonatol, 2020; 61(4):432\u2013438; doi: 10.1016\/j.pedneo.2020.03.017","journal-title":"Pediatr Neonatol"},{"issue":"5","key":"e_1_3_3_15_2","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1016\/j.ijantimicag.2005.02.006","article-title":"Mechanisms of quinolone resistance in Escherichia coli and Salmonella: Recent developments","volume":"25","author":"Hopkins KL","year":"2005","unstructured":"Hopkins KL, , Davies RH, , Threlfall EJ. Mechanisms of quinolone resistance in Escherichia coli and Salmonella: Recent developments. Int J Antimicrob Agents, 2005; 25(5):358\u2013373; doi: 10.1016\/j.ijantimicag.2005.02.006","journal-title":"Int J Antimicrob Agents"},{"issue":"8","key":"e_1_3_3_16_2","doi-asserted-by":"crossref","first-page":"1647","DOI":"10.1128\/AAC.35.8.1647","article-title":"Quinolone resistance-determining region in the DNA gyrase gyrB gene of Escherichia coli","volume":"35","author":"Yoshida H","year":"1991","unstructured":"Yoshida H, , Bogaki M, , Mika N, et al. Quinolone resistance-determining region in the DNA gyrase gyrB gene of Escherichia coli. Antimicrob Agents Chemother, 1991; 35(8):1647\u20131650; doi: 10.1128\/AAC.35.8.1647.","journal-title":"Antimicrob Agents Chemother"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1099\/jmm.0.000475"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1089\/mdr.2020.0437"},{"issue":"4","key":"e_1_3_3_19_2","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1128\/AAC.40.4.1009","article-title":"Mutations in gyrA gene of quinolone-resistant Salmonella serotypes isolated from humans and animals","volume":"40","author":"Griggs DJ","year":"1996","unstructured":"Griggs DJ, , Gensberg K, , Piddock LJ. Mutations in gyrA gene of quinolone-resistant Salmonella serotypes isolated from humans and animals. Antimicrob Agents Chemother. 1996; 40(4):1009\u20131013; doi: 10.1128\/AAC.40.4.1009","journal-title":"Antimicrob Agents Chemother"},{"issue":"12","key":"e_1_3_3_20_2","doi-asserted-by":"crossref","first-page":"2249","DOI":"10.1080\/09168451.2019.1650634","article-title":"WQ-3810 exerts high inhibitory effect on quinolone-resistant DNA gyrase of Salmonella typhimurium","volume":"83","author":"Koide K","year":"2019","unstructured":"Koide K, , Kongsoi S, , Nakajima C, et al. WQ-3810 exerts high inhibitory effect on quinolone-resistant DNA gyrase of Salmonella typhimurium. Biosci Biotechnol Biochem, 2019; 83(12):2249\u20132256; doi: 10.1080\/09168451.2019.1650634","journal-title":"Biosci Biotechnol Biochem"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1089\/mdr.2018.0078"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1089\/mdr.2020.0455"},{"key":"e_1_3_3_23_2","volume-title":"Performance Standards for Antimicrobial Susceptibility Testing","author":"Clinical and Laboratory Standard Institute (CLSI)","year":"2020","unstructured":"Clinical and Laboratory Standard Institute (CLSI). Performance Standards for Antimicrobial Susceptibility Testing. 30th Ed. CLSI Supplement M100 (ISBN 978-168440-066-9 [Print]; 978-1-68440-067-6 [Electronic]).; 2020.","edition":"30"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1089\/mdr.2016.0119"},{"issue":"5","key":"e_1_3_3_25_2","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/j.ijantimicag.2014.07.017","article-title":"In vitro activity of WQ-3810, a novel fluoroquinolone, against multidrug-resistant and fluoroquinolone-resistant pathogens","volume":"44","author":"Daichi K","year":"2014","unstructured":"Daichi K, , Aoi H, , Sugimoto K, et al. In vitro activity of WQ-3810, a novel fluoroquinolone, against multidrug-resistant and fluoroquinolone-resistant pathogens. Int J Antimicrob Agents, 2014; 44(5):443\u2013449; doi: 10.1016\/j.ijantimicag.2014.07.017","journal-title":"Int J Antimicrob Agents"},{"issue":"00","key":"e_1_3_3_26_2","first-page":"1","article-title":"Interaction of Quinolones carrying new R1 group with Mycobacterium leprae DNA gyrase","volume":"00","author":"Park J-H","year":"2021","unstructured":"Park J-H, , Yamaguchi T, , Ouchi Y, et al. Interaction of Quinolones carrying new R1 group with Mycobacterium leprae DNA gyrase. Microb Drug Resist, 2021; 00(00):1\u20138; doi: 10.1089\/mdr.2020.0408","journal-title":"Microb Drug Resist"},{"issue":"23","key":"e_1_3_3_27_2","article-title":"Quinolones: Mechanism, lethality and their contributions to antibiotic resistance","volume":"25","author":"Bush NG","year":"2020","unstructured":"Bush NG, , Diez-Santos I, , Abbott LR, et al. Quinolones: Mechanism, lethality and their contributions to antibiotic resistance. Molecules, 2020; 25(23); doi: 10.3390\/molecules25235662","journal-title":"Molecules"},{"issue":"2","key":"e_1_3_3_28_2","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1007\/BF02974013","article-title":"Structure-activity relationship of fluoroquinolone in Escherichia coli","volume":"21","author":"Lee S","year":"1998","unstructured":"Lee S, , Park T, , Lee Y. Structure-activity relationship of fluoroquinolone in Escherichia coli. Arch Pharm Res, 1998; 21(2):106\u2013112; doi: 10.1007\/BF02974013","journal-title":"Arch Pharm Res"},{"issue":"1","key":"e_1_3_3_29_2","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/0968-0896(96)83749-7","article-title":"Using SAR and QSAR analysis to model the activity and structure of the Quinolone-DNA complex","volume":"4","author":"Llorente B","year":"1996","unstructured":"Llorente B, , Leclerc F, , Cedergren R. Using SAR and QSAR analysis to model the activity and structure of the Quinolone-DNA complex. Bioorganic Med Chem, 1996; 4(1):61\u201371; doi: 10.1016\/0968-0896(96)83749-7","journal-title":"Bioorganic Med Chem"},{"issue":"6","key":"e_1_3_3_30_2","doi-asserted-by":"crossref","first-page":"1805","DOI":"10.1128\/AAC.46.6.1805-1815.2002","article-title":"Quinolone-binding pocket of DNA gyrase: Role of GyrB","volume":"46","author":"Heddle J","year":"2002","unstructured":"Heddle J, , Maxwell A. Quinolone-binding pocket of DNA gyrase: Role of GyrB. Antimicrob Agents Chemother, 2002; 46(6):1805\u20131815; doi: 10.1128\/AAC.46.6.1805-1815.2002","journal-title":"Antimicrob Agents Chemother"},{"issue":"3","key":"e_1_3_3_31_2","first-page":"10","article-title":"Quinolone molecular structure-activity relationships: What we have learned about improving antimicrobial activity","volume":"33","author":"Peterson LR","year":"2001","unstructured":"Peterson LR. Quinolone molecular structure-activity relationships: What we have learned about improving antimicrobial activity. Clin Infect Dis, 2001; 33(SUPPL. 3); doi: 10.1086\/321846","journal-title":"Clin Infect Dis"},{"issue":"10","key":"e_1_3_3_32_2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pgen.1009085","article-title":"DNA supercoiling differences in bacteria result from disparate DNA gyrase activation by polyamines","volume":"16","author":"Duprey A","year":"2020","unstructured":"Duprey A, , Groisman EA. DNA supercoiling differences in bacteria result from disparate DNA gyrase activation by polyamines. PLoS Genet, 2020; 16(10):1\u201320; doi: 10.1371\/journal.pgen.1009085","journal-title":"PLoS Genet"},{"issue":"4","key":"e_1_3_3_33_2","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1111\/j.1348-0421.1995.tb02196.x","article-title":"Analysis of the NH2-Terminal83 rd amino acid of Escherichia coli GyrA in quinolone-resistance","volume":"39","author":"Yonezawa M","year":"1995","unstructured":"Yonezawa M, , Takahata M, , Banzawa N, et al. Analysis of the NH2-Terminal83 rd amino acid of Escherichia coli GyrA in quinolone-resistance. Microbiol Immunol, 1995; 39(4):243\u2013247.","journal-title":"Microbiol Immunol"},{"issue":"34","key":"e_1_3_3_34_2","doi-asserted-by":"crossref","first-page":"5558","DOI":"10.1021\/bi500682e","article-title":"Role of the water-metal ion bridge in mediating interactions between quinolones and Escherichia coli topoisomerase IV","volume":"53","author":"Aldred KJ","year":"2014","unstructured":"Aldred KJ, , Breland EJ, , Vl\u010dkov\u00e1 V, et al. Role of the water-metal ion bridge in mediating interactions between quinolones and Escherichia coli topoisomerase IV. Biochemistry, 2014; 53(34):5558\u20135567; doi: 10.1021\/bi500682e","journal-title":"Biochemistry"},{"issue":"10","key":"e_1_3_3_35_2","doi-asserted-by":"crossref","first-page":"1905","DOI":"10.1021\/jm0205090","article-title":"A novel antibacterial 8-chloroquinolone with a distorted orientation of the N1-(5-amino-2,4-difluorophenyl) group","volume":"46","author":"Kuramoto Y","year":"2003","unstructured":"Kuramoto Y, , Ohshita Y, , Yoshida J, et al. A novel antibacterial 8-chloroquinolone with a distorted orientation of the N1-(5-amino-2,4-difluorophenyl) group. J Med Chem, 2003; 46(10):1905\u20131917; doi: 10.1021\/jm0205090","journal-title":"J Med Chem"},{"issue":"4","key":"e_1_3_3_36_2","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.jiac.2019.10.013","article-title":"WQ-3810 inhibits DNA gyrase activity in ofloxacin-resistant Mycobacterium leprae","volume":"26","author":"Park J-H","unstructured":"Park J-H, , Yamaguchi T, , Ouchi Y, et al. WQ-3810 inhibits DNA gyrase activity in ofloxacin-resistant Mycobacterium leprae. J Infect Chemother, 26(4):335\u2013342; doi: 10.1016\/j.jiac.2019.10.013","journal-title":"J Infect Chemother"},{"key":"e_1_3_3_37_2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s42003-020-0929-x","article-title":"The challenge of intracellular antibiotic accumulation, a function of fluoroquinolone influx versus bacterial efflux","volume":"3","author":"Vergalli J","year":"2020","unstructured":"Vergalli J, , Atzori A, , Pajovic J, et al. The challenge of intracellular antibiotic accumulation, a function of fluoroquinolone influx versus bacterial efflux. Commun Biol, 2020; 3:1; doi: 10.1038\/s42003-020-0929-x","journal-title":"Commun Biol"},{"key":"e_1_3_3_38_2","doi-asserted-by":"crossref","first-page":"10189","DOI":"10.1016\/j.tube.2019.101891","article-title":"WQ-3810: A new fluoroquinolone with a high potential against fluoroquinolone-resistant Mycobacterium tuberculosis","volume":"120","author":"Ouchi Y","year":"2020","unstructured":"Ouchi Y, , Mukai T, , Koide K, et al. WQ-3810: A new fluoroquinolone with a high potential against fluoroquinolone-resistant Mycobacterium tuberculosis. Tuberculosis, 2020; 120:10189; doi: 10.1016\/j.tube.2019.101891","journal-title":"Tuberculosis"}],"container-title":["Microbial Drug Resistance"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1089\/mdr.2023.0014","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/mdr.2023.0014","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/mdr.2023.0014","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T20:40:57Z","timestamp":1777668057000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/full\/10.1089\/mdr.2023.0014"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12]]},"references-count":37,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2023,12]]}},"alternative-id":["10.1089\/mdr.2023.0014"],"URL":"https:\/\/doi.org\/10.1089\/mdr.2023.0014","relation":{},"ISSN":["1076-6294","1931-8448"],"issn-type":[{"value":"1076-6294","type":"print"},{"value":"1931-8448","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,12]]}}}