{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T19:32:46Z","timestamp":1777923166371,"version":"3.51.4"},"reference-count":30,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Microbial Drug Resistance"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:p>\n                    <jats:italic toggle=\"yes\">Staphylococcus aureus<\/jats:italic>\n                    , the principal causative agent of osteomyelitis, can be internalized by osteoblasts and thereby escape from immune phagocytes and many kinds of antibiotics. To deliver antibiotics into osteoblasts to kill\n                    <jats:italic toggle=\"yes\">S. aureus<\/jats:italic>\n                    in the intracellular environment, we developed gentamicin-loaded chitosan nanoparticles and evaluated their intracellular bactericidal effect. We found decreased numbers of\n                    <jats:italic toggle=\"yes\">S. aureus<\/jats:italic>\n                    cells in infected osteoblasts treated with gentamicin-loaded chitosan nanoparticles. The cytotoxicity of the nanoparticles was evaluated by CCK-8 assay. There was no significant viability decrease at all tested concentrations. In conclusion, our results provide evidence for the potential use of gentamicin-loaded chitosan nanoparticles to enhance the delivery of gentamicin into cells and for their antibacterial effect against internalized\n                    <jats:italic toggle=\"yes\">S. aureus<\/jats:italic>\n                    in the intracellular environment of osteoblasts.\n                  <\/jats:p>","DOI":"10.1089\/mdr.2023.0066","type":"journal-article","created":{"date-parts":[[2024,4,5]],"date-time":"2024-04-05T15:17:25Z","timestamp":1712330245000},"page":"196-202","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Efficacy of Gentamicin-Loaded Chitosan Nanoparticles Against\n                    <i>Staphylococcus aureus<\/i>\n                    Internalized in Osteoblasts"],"prefix":"10.1177","volume":"30","author":[{"given":"Sifeng","family":"Shi","sequence":"first","affiliation":[{"name":"Department of Orthopedic Surgery, the Affiliated Hospital of Xuzhou Medical University, Xuzhou, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, the Affiliated Hospital of Xuzhou Medical University, Xuzhou, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xu","family":"Gu","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, the Affiliated Hospital of Xuzhou Medical University, Xuzhou, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiang","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, the Affiliated Hospital of Xuzhou Medical University, Xuzhou, China."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2024,5,23]]},"reference":[{"issue":"19","key":"e_1_3_4_2_2","doi-asserted-by":"crossref","first-page":"5834","DOI":"10.3390\/ma14195834","article-title":"Infections @ Trauma\/orthopedic implants: Recent advances on materials, methods, and microbes-a mini-review","volume":"14","author":"Wildemann B","year":"2021","unstructured":"Wildemann B, , Jandt KD. 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