{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T22:08:24Z","timestamp":1778278104567,"version":"3.51.4"},"reference-count":18,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Microbial Drug Resistance"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:p>\n                    <jats:italic toggle=\"yes\">Candida auris<\/jats:italic>\n                    is a concerning pathogen in health care due to its ability to spread in medical settings. In this study, we characterized the genome of three\n                    <jats:italic toggle=\"yes\">C. auris<\/jats:italic>\n                    clinical isolates collected in the Emilia-Romagna region of Northeastern Italy from January 2020 to May 2021. Whole-genome sequencing was performed using Illumina iSeq 100 and Oxford Nanopore MinION systems. Genomes were assembled with Flye. Phylogenetic analysis was carried out with RaxML. The ERG\n                    <jats:italic toggle=\"yes\">11<\/jats:italic>\n                    ,\n                    <jats:italic toggle=\"yes\">TAC1b<\/jats:italic>\n                    , and\n                    <jats:italic toggle=\"yes\">FKS1<\/jats:italic>\n                    genes were examined for known substitutions associated with resistance to azoles and caspofungin using Diamond. All three\n                    <jats:italic toggle=\"yes\">C. auris<\/jats:italic>\n                    isolates belonged to clade I (South Asian lineage) and showed high minimum inhibitory concentrations for fluconazole. Two of the three isolates were closely related to the first Italian index case of\n                    <jats:italic toggle=\"yes\">C. auris<\/jats:italic>\n                    occurred in the 2019 and carried similar mutations associated to azole resistance. The third isolate showed a greater phylogenetic distance from these strains and had a different genetic determinant not previously seen in Italy. Our data suggest that two\n                    <jats:italic toggle=\"yes\">C. auris<\/jats:italic>\n                    clinical isolates may have been epidemiologically related to the first outbreak previously observed in Italy, while the remaining isolate may have originated from a different source. Further research is needed to understand\n                    <jats:italic toggle=\"yes\">C. auris<\/jats:italic>\n                    transmission and resistance and to control its spread.\n                  <\/jats:p>","DOI":"10.1089\/mdr.2023.0150","type":"journal-article","created":{"date-parts":[[2023,10,18]],"date-time":"2023-10-18T11:45:27Z","timestamp":1697629527000},"page":"50-54","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Clonal Dissemination of\n                    <i>Candida auris<\/i>\n                    Clinical Isolates in Northern Italy, 2021"],"prefix":"10.1177","volume":"30","author":[{"given":"Stefano","family":"Amadesi","sequence":"first","affiliation":[{"name":"Operative Unit of Clinical Microbiology, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta","family":"Palombo","sequence":"additional","affiliation":[{"name":"Operative Unit of Clinical Microbiology, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Federica","family":"Bovo","sequence":"additional","affiliation":[{"name":"Operative Unit of Clinical Microbiology, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Liberatore","sequence":"additional","affiliation":[{"name":"Operative Unit of Clinical Microbiology, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena","family":"Vecchi","sequence":"additional","affiliation":[{"name":"Department of Public Health of Emilia-Romagna Region, Bologna, Italy."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monica","family":"Cricca","sequence":"additional","affiliation":[{"name":"Operative Unit of Clinical Microbiology, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy."},{"name":"DIMEC, University of Bologna, Bologna, Italy."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tiziana","family":"Lazzarotto","sequence":"additional","affiliation":[{"name":"Operative Unit of Clinical Microbiology, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy."},{"name":"DIMEC, University of Bologna, Bologna, Italy."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simone","family":"Ambretti","sequence":"additional","affiliation":[{"name":"Operative Unit of Clinical Microbiology, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy."},{"name":"DIMEC, University of Bologna, Bologna, Italy."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3791-8635","authenticated-orcid":false,"given":"Paolo","family":"Gaibani","sequence":"additional","affiliation":[{"name":"Operative Unit of Clinical Microbiology, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2024,1,11]]},"reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.1086\/421946"},{"key":"e_1_3_5_3_2","doi-asserted-by":"crossref","first-page":"615958","DOI":"10.1155\/2014\/615958","article-title":"Non- albicans Candida infection: An emerging threat","volume":"2014","author":"Deorukhkar SC","year":"2014","unstructured":"Deorukhkar SC, , Saini S, , Mathew S. Non- albicans Candida infection: An emerging threat. Interdiscip Perspect Infect Dis, 2014; 2014:615958; doi: 10.1155\/2014\/615958","journal-title":"Interdiscip Perspect Infect Dis"},{"issue":"2","key":"e_1_3_5_4_2","doi-asserted-by":"crossref","first-page":"e03333","DOI":"10.1128\/mBio.03333-20","article-title":"Genome-wide analysis of experimentally evolved Candida auris reveals multiple novel mechanisms of multidrug resistance","volume":"12","author":"Carolus H","year":"2021","unstructured":"Carolus H, , Pierson S, , Mu\u00f1oz JF, et al. Genome-wide analysis of experimentally evolved Candida auris reveals multiple novel mechanisms of multidrug resistance. MBio, 2021; 12(2):e03333-20; doi: 10.1128\/mBio.03333-20","journal-title":"MBio"},{"issue":"9","key":"e_1_3_5_5_2","first-page":"e10334","article-title":"Candida auris in the age of resistance","volume":"12","author":"Oh M","year":"2020","unstructured":"Oh M, , Heyl J, , Babu BA. Candida auris in the age of resistance. Cureus, 2020; 12(9):e10334; doi: 10.7759\/cureus.10334","journal-title":"Cureus"},{"issue":"10","key":"e_1_3_5_6_2","doi-asserted-by":"crossref","first-page":"e1008921","DOI":"10.1371\/journal.ppat.1008921","article-title":"Candida auris: Epidemiology, biology, antifungal resistance, and virulence","volume":"16","author":"Du H","year":"2020","unstructured":"Du H, , Bing J, , Hu T, et al. Candida auris: Epidemiology, biology, antifungal resistance, and virulence. PLoS Pathog, 2020; 16(10):e1008921; doi: 10.1371\/journal.ppat.1008921","journal-title":"PLoS Pathog"},{"issue":"1","key":"e_1_3_5_7_2","doi-asserted-by":"crossref","first-page":"2405","DOI":"10.1080\/22221751.2022.2125349","article-title":"Confirmation of fifth Candida auris clade by whole genome sequencing","volume":"11","author":"Spruijtenburg B","year":"2022","unstructured":"Spruijtenburg B, , Badali H, , Abastabar M, et al. Confirmation of fifth Candida auris clade by whole genome sequencing. 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Am J Transplant, 2017; 17(1):296\u2013299; doi: 10.1111\/ajt.14121","journal-title":"Am J Transplant"},{"issue":"10","key":"e_1_3_5_9_2","doi-asserted-by":"crossref","first-page":"2996","DOI":"10.1128\/JCM.00921-17","article-title":"Survival, persistence, and isolation of the emerging multidrug-resistant pathogenic yeast Candida auris on a plastic health care surface","volume":"55","author":"Welsh RM","year":"2017","unstructured":"Welsh RM, , Bentz ML, , Shams A, et al. Survival, persistence, and isolation of the emerging multidrug-resistant pathogenic yeast Candida auris on a plastic health care surface. 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