{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T17:32:26Z","timestamp":1787851946650,"version":"build-2784847793"},"reference-count":30,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Microbial Drug Resistance"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:p>\n                    Updated data on genital Mollicutes prevalence and antimicrobial susceptibility can help provide guidance for antibiotic stewardship and set up effective strategies for infection control policies. In this multicentre study, we assessed the prevalence and the resistance profile of\n                    <jats:italic toggle=\"yes\">Mycoplasma hominis<\/jats:italic>\n                    (MH) and\n                    <jats:italic toggle=\"yes\">Ureaplasma<\/jats:italic>\n                    species (\n                    <jats:italic toggle=\"yes\">U. parvum\/U. urealyticum<\/jats:italic>\n                    ), analyzing data from 21,210 subjects who provided urogenital samples for Mollicutes detection by culture over a 5-year period (2017\u20132021) in two high-density urban areas in the North of Italy (\n                    <jats:italic toggle=\"yes\">i.e.<\/jats:italic>\n                    , Bologna and Lecco). Overall prevalence of Mollicutes infection was 22.3%, with women showing a significantly higher detection rate than men (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009&lt;\u20090.00001). The prevalence decreased with age (highest prevalence &lt;30 years) and over the years considered.\n                    <jats:italic toggle=\"yes\">Ureaplasma<\/jats:italic>\n                    strains were much more frequently detected (62.3%) compared to MH (8.3%) and to mixed infections (29.4%).\n                    <jats:italic toggle=\"yes\">Ureaplasma<\/jats:italic>\n                    species showed high levels of ciprofloxacin resistance (39.5%), whereas MH strains were nonsusceptible to azithromycin and roxithromycin in about 60% of cases. Over time, a significant decrease of resistance to azithromycin and doxycycline was detected (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009&lt;\u20090.0001 and 0.0004, respectively), in parallel with an important increase of ciprofloxacin-resistance levels (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009&lt;\u20090.0001). Overall, our results revealed that minocycline and josamycin can be first-line drugs for Mollicutes empirical treatment.\n                  <\/jats:p>","DOI":"10.1089\/mdr.2023.0202","type":"journal-article","created":{"date-parts":[[2023,12,7]],"date-time":"2023-12-07T14:48:40Z","timestamp":1701960520000},"page":"55-60","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":7,"title":["Antimicrobial Resistance of Genital\n                    <i>Mycoplasma<\/i>\n                    and\n                    <i>Ureaplasma<\/i>\n                    : A Multicentre Study Over a 5-Year Period in Italy (2017\u20132021)"],"prefix":"10.1177","volume":"30","author":[{"given":"Matteo","family":"Pavoni","sequence":"first","affiliation":[{"name":"Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luigi","family":"Principe","sequence":"additional","affiliation":[{"name":"Clinical Pathology and Microbiology Unit, San Giovanni di Dio Hospital, Crotone, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudio","family":"Foschi","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy."},{"name":"Microbiology Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisa","family":"Meroni","sequence":"additional","affiliation":[{"name":"Clinical Microbiology and Virology Unit, A. Manzoni Hospital, Lecco, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Briozzo","sequence":"additional","affiliation":[{"name":"Clinical Microbiology and Virology Unit, A. Manzoni Hospital, Lecco, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiziana","family":"Lazzarotto","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy."},{"name":"Microbiology Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simone","family":"Ambretti","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy."},{"name":"Microbiology Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Di Bella","sequence":"additional","affiliation":[{"name":"Clinical Department of Medical, Surgical and Health Sciences, University of Trieste, Trieste, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,1,11]]},"reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.resmic.2017.02.009"},{"key":"e_1_3_5_3_2","doi-asserted-by":"crossref","first-page":"8842267","DOI":"10.1155\/2021\/8842267","article-title":"Infection prevalence and antibiotic resistance levels in Ureaplasma urealyticum and Mycoplasma hominis in gynecological outpatients of a Tertiary Hospital in China from 2015 to 2018","volume":"2021","author":"Zhang W","year":"2021","unstructured":"Zhang W, , Li L, , Zhang X, et al. 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