{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T02:35:42Z","timestamp":1789439742933,"version":"build-2803163510"},"reference-count":62,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2024,1,29]],"date-time":"2024-01-29T00:00:00Z","timestamp":1706486400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Microbial Drug Resistance"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:p>\n                    Methicillin-resistant\n                    <jats:italic toggle=\"yes\">Staphylococcus aureus<\/jats:italic>\n                    (MRSA) is a major infectious disease pathogen, and its molecular epidemiological profile has been changing. In this study, a total of 279 MRSA isolates were collected from patients with bloodstream infection (BSI) in Hokkaido, northern main island of Japan, for a 2-year period from August 2019 to July 2021. CC5 (ST5\/ST764)-MRSA-IIa (SCC\n                    <jats:italic toggle=\"yes\">mec<\/jats:italic>\n                    -IIa) (47%,\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    \u2009=\u2009132) and CC1 (ST1\/ST2725\/ST2764)-MRSA-IVa (42%,\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    \u2009=\u2009116) were found to be major lineages, with CC8-MRSA-IVa being lower prevalence (5%,\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    \u2009=\u200913). CC1-MRSA-IVa showed a relatively increased proportion compared with our previous study (22%, 2017\u20132019). Seven isolates with SCC\n                    <jats:italic toggle=\"yes\">mec<\/jats:italic>\n                    IVa (2.5%) were positive for Panton\u2013Valentine leukocidin genes on \u03a6Sa2usa and belonged to ST8\/\n                    <jats:italic toggle=\"yes\">spa<\/jats:italic>\n                    -t008\/\n                    <jats:italic toggle=\"yes\">agr<\/jats:italic>\n                    -I\/\n                    <jats:italic toggle=\"yes\">coa<\/jats:italic>\n                    -IIIa, showing genetic features of the USA300 clone. Among these isolates, six isolates harbored arginine catabolic mobile element (ACME) type I typical to the USA300 clone, while it was not detected in an isolate (strain R3-8). Whole genomic analysis of strain R3-8 revealed that its chromosome was highly similar to the USA300 strain TCH1516, but lacked ACME, carrying a plasmid genetically close to that of USA300 strains. The present study revealed increasing trend of CC1-MRSA-IV and occurrence of a novel variant of the USA300 clone among MRSA from BSI in northern Japan.\n                  <\/jats:p>","DOI":"10.1089\/mdr.2023.0203","type":"journal-article","created":{"date-parts":[[2023,12,15]],"date-time":"2023-12-15T11:41:31Z","timestamp":1702640491000},"page":"63-72","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":16,"title":["Molecular Epidemiological Characterization of Methicillin-Resistant\n                    <i>Staphylococcus aureus<\/i>\n                    from Bloodstream Infections in Northern Japan: Increasing Trend of CC1 and Identification of ST8-SCC\n                    <i>mec<\/i>\n                    IVa USA300-Like Isolate Lacking Arginine Catabolic Mobile Element"],"prefix":"10.1177","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8402-5349","authenticated-orcid":false,"given":"Meiji Soe","family":"Aung","sequence":"first","affiliation":[{"name":"Department of Hygiene, Sapporo Medical University School of Medicine, Sapporo, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noriko","family":"Urushibara","sequence":"additional","affiliation":[{"name":"Department of Hygiene, Sapporo Medical University School of Medicine, Sapporo, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7582-0228","authenticated-orcid":false,"given":"Mitsuyo","family":"Kawaguchiya","sequence":"additional","affiliation":[{"name":"Department of Hygiene, Sapporo Medical University School of Medicine, Sapporo, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobuhide","family":"Ohashi","sequence":"additional","affiliation":[{"name":"Department of Hygiene, Sapporo Medical University School of Medicine, Sapporo, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mina","family":"Hirose","sequence":"additional","affiliation":[{"name":"Division of Pediatric Dentistry, Department of Oral Growth and Development, School of Dentistry, Health Sciences University of Hokkaido, Hokkaido, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuuki","family":"Kimura","sequence":"additional","affiliation":[{"name":"Sapporo Clinical Laboratory, Incorporated, Hokkaido, Sapporo, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenji","family":"Kudo","sequence":"additional","affiliation":[{"name":"Sapporo Clinical Laboratory, Incorporated, Hokkaido, Sapporo, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahiko","family":"Ito","sequence":"additional","affiliation":[{"name":"Sapporo Clinical Laboratory, Incorporated, Hokkaido, Sapporo, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobumichi","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"Department of Hygiene, Sapporo Medical University School of Medicine, Sapporo, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,1,29]]},"reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00002-14"},{"issue":"5","key":"e_1_3_5_3_2","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1111\/j.1469-0691.2012.03903.x","article-title":"The changing epidemiology of Staphylococcus aureus bloodstream infection: A multinational population-based surveillance study","volume":"19","author":"Laupland KB","year":"2013","unstructured":"Laupland KB, , Lyytik\u00e4inen O, , S\u00f8gaard M, et al. The changing epidemiology of Staphylococcus aureus bloodstream infection: A multinational population-based surveillance study. Clin Microbiol Infect, 2013; 19(5):465\u2013471; doi: 10.1111\/j.1469-0691.2012.03903.x","journal-title":"Clin Microbiol Infect"},{"issue":"8","key":"e_1_3_5_4_2","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1016\/j.cmi.2022.03.015","article-title":"Staphylococcus aureus bacteraemia mortality: A systematic review and meta-analysis","volume":"28","author":"Bai AD","year":"2022","unstructured":"Bai AD, , Lo CKL, , Komorowski AS, et al. Staphylococcus aureus bacteraemia mortality: A systematic review and meta-analysis. Clin Microbiol Infect, 2022; 28(8):1076\u20131084; doi: 10.1016\/j.cmi.2022.03.015","journal-title":"Clin Microbiol Infect"},{"issue":"1","key":"e_1_3_5_5_2","doi-asserted-by":"crossref","first-page":"e147","DOI":"10.1017\/ash.2022.280","article-title":"Cost and healthcare utilization of methicillin-resistant Staphylococcus aureus bacteremia estimated from linked antimicrobial resistance surveillance and hospital claims data in Japan","volume":"2","author":"Shoji T","year":"2022","unstructured":"Shoji T, , Muto R, , Fukuda H, et al. Cost and healthcare utilization of methicillin-resistant Staphylococcus aureus bacteremia estimated from linked antimicrobial resistance surveillance and hospital claims data in Japan. Antimicrob Steward Healthc Epidemiol, 2022; 2(1):e147; doi: 10.1017\/ash.2022.280","journal-title":"Antimicrob Steward Healthc Epidemiol"},{"key":"e_1_3_5_6_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00020-18"},{"issue":"4","key":"e_1_3_5_7_2","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1093\/jac\/dkab500","article-title":"Novel SCCmec type XV (7A) and two pseudo-SCCmec variants in foodborne MRSA in China","volume":"77","author":"Wang W","year":"2022","unstructured":"Wang W, , Hu Y, , Baker M, et al. Novel SCCmec type XV (7A) and two pseudo-SCCmec variants in foodborne MRSA in China. J Antimicrob Chemother, 2022; 77(4):903\u2013909; doi: 10.1093\/jac\/dkab500","journal-title":"J Antimicrob Chemother"},{"key":"e_1_3_5_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro2200"},{"key":"e_1_3_5_9_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00081-09"},{"issue":"5","key":"e_1_3_5_10_2","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1016\/j.mib.2012.08.003","article-title":"Global epidemiology of community-associated methicillin resistant Staphylococcus aureus (CA-MRSA)","volume":"15","author":"Mediavilla JR","year":"2012","unstructured":"Mediavilla JR, , Chen L, , Mathema B, et al. Global epidemiology of community-associated methicillin resistant Staphylococcus aureus (CA-MRSA). Curr Opin Microbiol, 2012; 15(5):588\u2013595; doi: 10.1016\/j.mib.2012.08.003","journal-title":"Curr Opin Microbiol"},{"key":"e_1_3_5_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2018.33"},{"key":"e_1_3_5_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)61999-1"},{"issue":"16","key":"e_1_3_5_13_2","doi-asserted-by":"crossref","first-page":"e104","DOI":"10.3346\/jkms.2021.36.e104","article-title":"A longitudinal study of adult patients with Staphylococcus aureus bacteremia over 11 years in Korea","volume":"36","author":"Choi SH","year":"2021","unstructured":"Choi SH, , Lee J, , Jung J, et al. A longitudinal study of adult patients with Staphylococcus aureus bacteremia over 11 years in Korea. J Korean Med Sci, 2021; 36(16):e104; doi: 10.3346\/jkms.2021.36.e104","journal-title":"J Korean Med Sci"},{"issue":"1","key":"e_1_3_5_14_2","doi-asserted-by":"crossref","first-page":"15677","DOI":"10.1038\/s41598-021-95115-2","article-title":"Changing characteristics of S. aureus bacteremia caused by PVL-negative, MRSA strain over 11 years","volume":"11","author":"Yang E","year":"2021","unstructured":"Yang E, , Kim E, , Chung H, et al. Changing characteristics of S. aureus bacteremia caused by PVL-negative, MRSA strain over 11 years. Sci Rep, 2021; 11(1):15677; doi: 10.1038\/s41598-021-95115-2","journal-title":"Sci Rep"},{"issue":"1","key":"e_1_3_5_15_2","doi-asserted-by":"crossref","first-page":"1908","DOI":"10.1080\/22221751.2021.1981158","article-title":"Sequence type 8 as an emerging clone of methicillin-resistant Staphylococcus aureus causing bloodstream infections in Taiwan","volume":"10","author":"Chen PY","year":"2021","unstructured":"Chen PY, , Chuang YC, , Wang JT, et al. Sequence type 8 as an emerging clone of methicillin-resistant Staphylococcus aureus causing bloodstream infections in Taiwan. Emerg Microbes Infect, 2021; 10(1):1908\u20131918; doi: 10.1080\/22221751.2021.1981158","journal-title":"Emerg Microbes Infect"},{"issue":"3","key":"e_1_3_5_16_2","doi-asserted-by":"crossref","first-page":"106534","DOI":"10.1016\/j.ijantimicag.2022.106534","article-title":"USA300 (sequence type 8) has become a major clone of methicillin-resistant Staphylococcus aureus in northern Taiwan","volume":"59","author":"Huang YC","year":"2022","unstructured":"Huang YC, , Chen CJ. USA300 (sequence type 8) has become a major clone of methicillin-resistant Staphylococcus aureus in northern Taiwan. Int J Antimicrob Agents, 2022; 59(3):106534; doi: 10.1016\/j.ijantimicag.2022.106534","journal-title":"Int J Antimicrob Agents"},{"key":"e_1_3_5_17_2","doi-asserted-by":"crossref","first-page":"104567","DOI":"10.1016\/j.meegid.2020.104567","article-title":"Methicillin-resistant Staphylococcus aureus bacteraemia, 2003\u20132015: Comparative evaluation of changing trends in molecular epidemiology and clinical outcomes of infections","volume":"85","author":"Niek WK","year":"2020","unstructured":"Niek WK, , Teh CSJ, , Idris N, et al. Methicillin-resistant Staphylococcus aureus bacteraemia, 2003\u20132015: Comparative evaluation of changing trends in molecular epidemiology and clinical outcomes of infections. Infect Genet Evol, 2020; 85:104567; doi: 10.1016\/j.meegid.2020.104567","journal-title":"Infect Genet Evol"},{"issue":"3","key":"e_1_3_5_18_2","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.idh.2019.04.002","article-title":"Molecular epidemiology of methicillin-resistant Staphylococcus aureus isolates in New South Wales, Australia, 2012\u20132017","volume":"24","author":"Dotel R","year":"2019","unstructured":"Dotel R, , O'Sullivan MVN, , Davis JS, et al. Molecular epidemiology of methicillin-resistant Staphylococcus aureus isolates in New South Wales, Australia, 2012\u20132017. Infect Dis Health, 2019; 24(3):134\u2013140; doi: 10.1016\/j.idh.2019.04.002","journal-title":"Infect Dis Health"},{"issue":"12","key":"e_1_3_5_19_2","doi-asserted-by":"crossref","first-page":"2401","DOI":"10.3390\/microorganisms10122401","article-title":"Molecular epidemiology, antimicrobial susceptibility, and clinical features of methicillin-resistant Staphylococcus aureus bloodstream infections over 30 years in Barcelona, Spain (1990\u20132019)","volume":"10","author":"V\u00e1zquez-S\u00e1nchez DA","year":"2022","unstructured":"V\u00e1zquez-S\u00e1nchez DA, , Grillo S, , Carrera-Salinas A, et al. Molecular epidemiology, antimicrobial susceptibility, and clinical features of methicillin-resistant Staphylococcus aureus bloodstream infections over 30 years in Barcelona, Spain (1990\u20132019). Microorganisms, 2022; 10(12):2401; doi: 10.3390\/microorganisms10122401","journal-title":"Microorganisms"},{"issue":"11","key":"e_1_3_5_20_2","doi-asserted-by":"crossref","first-page":"2127","DOI":"10.1007\/s10096-019-03653-5","article-title":"Increasing incidence of bloodstream infections due to Staphylococcus aureus clonal complex 398 in a French hospital between 2010 and 2017","volume":"38","author":"Sauget M","year":"2019","unstructured":"Sauget M, , Bouiller K, , Richard M, et al. Increasing incidence of bloodstream infections due to Staphylococcus aureus clonal complex 398 in a French hospital between 2010 and 2017. Eur J Clin Microbiol Infect Dis, 2019; 38(11):2127\u20132132; doi: 10.1007\/s10096-019-03653-5","journal-title":"Eur J Clin Microbiol Infect Dis"},{"issue":"11","key":"e_1_3_5_21_2","doi-asserted-by":"crossref","first-page":"1868","DOI":"10.1093\/cid\/ciz112","article-title":"Changing characteristics of Staphylococcus aureus bacteremia: Results from a 21-year, prospective, longitudinal study","volume":"69","author":"Souli M","year":"2019","unstructured":"Souli M, , Ruffin F, , Choi SH, et al. Changing characteristics of Staphylococcus aureus bacteremia: Results from a 21-year, prospective, longitudinal study. Clin Infect Dis, 2019; 69(11):1868\u20131877; doi: 10.1093\/cid\/ciz112","journal-title":"Clin Infect Dis"},{"issue":"11","key":"e_1_3_5_22_2","doi-asserted-by":"crossref","first-page":"1973","DOI":"10.3201\/eid2111.150452","article-title":"USA300 methicillin-resistant Staphylococcus aureus, United States, 2000\u20132013","volume":"21","author":"Carrel M","year":"2015","unstructured":"Carrel M, , Perencevich EN, , David MZ. USA300 methicillin-resistant Staphylococcus aureus, United States, 2000\u20132013. Emerg Infect Dis, 2015; 21(11):1973\u20131980; doi: 10.3201\/eid2111.150452","journal-title":"Emerg Infect Dis"},{"issue":"8","key":"e_1_3_5_23_2","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1111\/j.1469-0691.2012.03822.x","article-title":"USA300 abroad: Global spread of a virulent strain of community-associated methicillin-resistant Staphylococcus aureus","volume":"18","author":"Nimmo GR","year":"2012","unstructured":"Nimmo GR. USA300 abroad: Global spread of a virulent strain of community-associated methicillin-resistant Staphylococcus aureus. Clin Microbiol Infect, 2012; 18(8):725\u2013734. doi: 10.1111\/j.1469-0691.2012.03822.x","journal-title":"Clin Microbiol Infect"},{"issue":"9512","key":"e_1_3_5_24_2","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1016\/S0140-6736(06)68231-7","article-title":"Complete genome sequence of USA300, an epidemic clone of community-acquired methicillin-resistant Staphylococcus aureus","volume":"367","author":"Diep BA","year":"2006","unstructured":"Diep BA, , Gill SR, , Chang RF, et al. Complete genome sequence of USA300, an epidemic clone of community-acquired methicillin-resistant Staphylococcus aureus. Lancet, 2006; 367(9512):731\u2013739; doi: 10.1016\/S0140-6736(06)68231-7","journal-title":"Lancet"},{"issue":"10","key":"e_1_3_5_25_2","doi-asserted-by":"crossref","first-page":"677","DOI":"10.3390\/toxins13100677","article-title":"Staphylococcus aureus toxins: An update on their pathogenic properties and potential treatments","volume":"13","author":"Ahmad-Mansour N","year":"2021","unstructured":"Ahmad-Mansour N, , Loubet P, , Pouget C, et al. Staphylococcus aureus toxins: An update on their pathogenic properties and potential treatments. Toxins (Basel), 2021; 13(10):677; doi: 10.3390\/toxins13100677","journal-title":"Toxins (Basel)"},{"key":"e_1_3_5_26_2","doi-asserted-by":"publisher","DOI":"10.1080\/21505594.2021.1878688"},{"issue":"4","key":"e_1_3_5_27_2","doi-asserted-by":"crossref","first-page":"e0227221","DOI":"10.1128\/spectrum.02272-21","article-title":"Changes in the genotypic characteristics of community-acquired methicillin-resistant Staphylococcus aureus collected in 244 medical facilities in Japan between 2010 and 2018: A nationwide surveillance","volume":"10","author":"Yamaguchi T","year":"2022","unstructured":"Yamaguchi T, , Nakamura I, , Sato T, et al. Changes in the genotypic characteristics of community-acquired methicillin-resistant Staphylococcus aureus collected in 244 medical facilities in Japan between 2010 and 2018: A nationwide surveillance. Microbiol Spectr, 2022; 10(4):e0227221; doi: 10.1128\/spectrum.02272-21","journal-title":"Microbiol Spectr"},{"issue":"11","key":"e_1_3_5_28_2","doi-asserted-by":"crossref","DOI":"10.1016\/j.cmi.2018.02.012","article-title":"Dissemination of Panton-Valentine leukocidin-positive methicillin-resistant Staphylococcus aureus USA300 clone in multiple hospitals in Tokyo, Japan","volume":"24","author":"Takadama S","year":"2018","unstructured":"Takadama S, , Nakaminami H, , Sato A, et al. Dissemination of Panton-Valentine leukocidin-positive methicillin-resistant Staphylococcus aureus USA300 clone in multiple hospitals in Tokyo, Japan. Clin Microbiol Infect, 2018; 24(11):1211.e1\u2013e1211.e7; doi: 10.1016\/j.cmi.2018.02.012","journal-title":"Clin Microbiol Infect"},{"issue":"7","key":"e_1_3_5_29_2","doi-asserted-by":"crossref","first-page":"e0271115","DOI":"10.1371\/journal.pone.0271115","article-title":"Relationship between mortality and molecular epidemiology of methicillin-resistant Staphylococcus aureus bacteremia","volume":"17","author":"Shimizu M","year":"2022","unstructured":"Shimizu M, , Mihara T, , Ohara J. Relationship between mortality and molecular epidemiology of methicillin-resistant Staphylococcus aureus bacteremia. PLoS One, 2022; 17(7):e0271115; doi: 10.1371\/journal.pone.0271115","journal-title":"PLoS One"},{"key":"e_1_3_5_30_2","doi-asserted-by":"crossref","first-page":"602833","DOI":"10.3389\/fcimb.2021.602833","article-title":"Increased incidence and plasma-biofilm formation ability of SCCmec type IV Methicillin-resistant Staphylococcus aureus (MRSA) isolated from patients with bacteremia","volume":"11","author":"Hamada M","year":"2021","unstructured":"Hamada M, , Yamaguchi T, , Sato A, et al. Increased incidence and plasma-biofilm formation ability of SCCmec type IV Methicillin-resistant Staphylococcus aureus (MRSA) isolated from patients with bacteremia. Front Cell Infect Microbiol, 2021; 11:602833; doi: 10.3389\/fcimb.2021.602833","journal-title":"Front Cell Infect Microbiol"},{"issue":"8","key":"e_1_3_5_31_2","doi-asserted-by":"crossref","first-page":"2130","DOI":"10.1093\/jac\/dkac154","article-title":"Changing molecular epidemiology and characteristics of MRSA isolated from bloodstream infections: Nationwide surveillance in Japan in 2019","volume":"77","author":"Kaku N","year":"2022","unstructured":"Kaku N, , Sasaki D, , Ota K, et al. Changing molecular epidemiology and characteristics of MRSA isolated from bloodstream infections: Nationwide surveillance in Japan in 2019. J Antimicrob Chemother, 2022; 77(8):2130\u20132141. doi: 10.1093\/jac\/dkac154","journal-title":"J Antimicrob Chemother"},{"key":"e_1_3_5_32_2","doi-asserted-by":"publisher","DOI":"10.1089\/mdr.2016.0176"},{"key":"e_1_3_5_33_2","doi-asserted-by":"publisher","DOI":"10.1089\/mdr.2018.0468"},{"key":"e_1_3_5_34_2","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.jgar.2020.12.008","article-title":"Clonal diversity of methicillin-resistant Staphylococcus aureus (MRSA) from bloodstream infections in northern Japan: Identification of spermidine N-acetyltransferase gene (speG) in staphylococcal cassette chromosomes (SCCs) associated with type II and IV SCCmec","volume":"24","author":"Aung MS","year":"2021","unstructured":"Aung MS, , Urushibara N, , Kawaguchiya M, et al. Clonal diversity of methicillin-resistant Staphylococcus aureus (MRSA) from bloodstream infections in northern Japan: Identification of spermidine N-acetyltransferase gene (speG) in staphylococcal cassette chromosomes (SCCs) associated with type II and IV SCCmec. J Glob Antimicrob Resist, 2021; 24:207\u2013214; doi: 10.1016\/j.jgar.2020.12.008","journal-title":"J Glob Antimicrob Resist"},{"key":"e_1_3_5_35_2","volume-title":"Performance Standards for Antimicrobial Susceptibility Testing","author":"Clinical and Laboratory Standards Institute (CLSI)","year":"2022","unstructured":"Clinical and Laboratory Standards Institute (CLSI). Performance Standards for Antimicrobial Susceptibility Testing. Thirty-Two. Informational Supplement, M100-S32, Wayne, PA, USA; 2022."},{"key":"e_1_3_5_36_2","unstructured":"The European Committee on Antimicrobial Susceptibility Testing (EUCAST). Breakpoint Tables for Interpretation of MICs and Zone Diameters Version 12.0; 2022. Available from: www.eucast.org [Last accessed: December13 2022]."},{"issue":"5","key":"e_1_3_5_37_2","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1007\/s10156-012-0434-3","article-title":"Nationwide surveillance of bacterial respiratory pathogens conducted by the Surveillance Committee of Japanese Society of Chemotherapy, Japanese Association for Infectious Diseases, and Japanese Society for Clinical Microbiology in 2009: General view of the pathogens' antibacterial susceptibility","volume":"18","author":"Watanabe A","year":"2012","unstructured":"Watanabe A, , Yanagihara K, , Matsumoto T, et al. Nationwide surveillance of bacterial respiratory pathogens conducted by the Surveillance Committee of Japanese Society of Chemotherapy, Japanese Association for Infectious Diseases, and Japanese Society for Clinical Microbiology in 2009: General view of the pathogens' antibacterial susceptibility. J Infect Chemother, 2012; 18(5):609\u2013620; doi: 10.1007\/s10156-012-0434-3","journal-title":"J Infect Chemother"},{"issue":"3","key":"e_1_3_5_38_2","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1128\/JCM.01309-07","article-title":"Novel multiplex PCR assay for simultaneous identification of community-associated methicillin-resistant Staphylococcus aureus strains USA300 and USA400 and detection of mecA and Panton-Valentine Leukocidin genes, with discrimination of Staphylococcus aureus from coagulase-negative staphylococci","volume":"46","author":"Zhang K","year":"2008","unstructured":"Zhang K, , McClure JA, , Elsayed S, et al. Novel multiplex PCR assay for simultaneous identification of community-associated methicillin-resistant Staphylococcus aureus strains USA300 and USA400 and detection of mecA and Panton-Valentine Leukocidin genes, with discrimination of Staphylococcus aureus from coagulase-negative staphylococci. J Clin Microbiol, 2008; 46(3):1118\u20131122; doi: 10.1128\/JCM.01309-07","journal-title":"J Clin Microbiol"},{"key":"e_1_3_5_39_2","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.2217\/fmb-2016-0017","article-title":"Identification of Staphylococcus argenteus in Eastern China based on a nonribosomal peptide synthetase (NRPS) gene","volume":"11","author":"Zhang DF","year":"2016","unstructured":"Zhang DF, , Xu X, , Song Q, et al. Identification of Staphylococcus argenteus in Eastern China based on a nonribosomal peptide synthetase (NRPS) gene. Future Microbiol, 2016; 11:1113\u20131121; doi: 10.2217\/fmb-2016-0017","journal-title":"Future Microbiol"},{"key":"e_1_3_5_40_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00165-06"},{"issue":"1","key":"e_1_3_5_41_2","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1093\/jac\/dkm112","article-title":"Multiplex PCR strategy for subtyping the staphylococcal cassette chromosome mec type IV in methicillin-resistant Staphylococcus aureus: \u2018SCCmec IV multiplex\u2019","volume":"60","author":"Milheiri\u00e7o C","year":"2007","unstructured":"Milheiri\u00e7o C, , Oliveira DC, , de Lencastre H. Multiplex PCR strategy for subtyping the staphylococcal cassette chromosome mec type IV in methicillin-resistant Staphylococcus aureus: \u2018SCCmec IV multiplex\u2019. J Antimicrob Chemother, 2007; 60(1):42\u201348; doi: 10.1093\/jac\/dkm112","journal-title":"J Antimicrob Chemother"},{"key":"e_1_3_5_42_2","doi-asserted-by":"publisher","DOI":"10.1089\/mdr.2019.0208"},{"key":"e_1_3_5_43_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.37.11.3556-3563.1999"},{"issue":"1","key":"e_1_3_5_44_2","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1099\/jmm.0.000869","article-title":"Molecular characterization of Staphylococcus argenteus in Myanmar: Identification of novel genotypes\/clusters in staphylocoagulase, protein A, alpha-haemolysin and other virulence factors","volume":"68","author":"Aung MS","year":"2019","unstructured":"Aung MS, , San T, , San N, et al. Molecular characterization of Staphylococcus argenteus in Myanmar: Identification of novel genotypes\/clusters in staphylocoagulase, protein A, alpha-haemolysin and other virulence factors. J Med Microbiol, 2019; 68(1):95\u2013104; doi: 10.1099\/jmm.0.000869","journal-title":"J Med Microbiol"},{"key":"e_1_3_5_45_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.38.3.1008-1015.2000"},{"issue":"5","key":"e_1_3_5_46_2","doi-asserted-by":"crossref","first-page":"347","DOI":"10.3390\/toxins12050347","article-title":"Prevalence and genetic diversity of staphylococcal enterotoxin (-like) genes sey, selw, selx, selz, sel26 and sel27 in community-acquired methicillin-resistant Staphylococcus aureus","volume":"12","author":"Aung MS","year":"2020","unstructured":"Aung MS, , Urushibara N, , Kawaguchiya M, et al. Prevalence and genetic diversity of staphylococcal enterotoxin (-like) genes sey, selw, selx, selz, sel26 and sel27 in community-acquired methicillin-resistant Staphylococcus aureus. Toxins (Basel), 2020; 12(5):347; doi: 10.3390\/toxins12050347","journal-title":"Toxins (Basel)"},{"issue":"2","key":"e_1_3_5_47_2","doi-asserted-by":"crossref","first-page":"163","DOI":"10.3390\/pathogens10020163","article-title":"Distribution of virulence factors and resistance determinants in three genotypes of Staphylococcus argenteus clinical isolates in Japan","volume":"10","author":"Aung MS","year":"2021","unstructured":"Aung MS, , Urushibara N, , Kawaguchiya M, et al. Distribution of virulence factors and resistance determinants in three genotypes of Staphylococcus argenteus clinical isolates in Japan. Pathogens, 2021; 10(2):163; doi: 10.3390\/pathogens10020163","journal-title":"Pathogens"},{"issue":"1","key":"e_1_3_5_48_2","doi-asserted-by":"crossref","first-page":"108","DOI":"10.3390\/antibiotics12010108","article-title":"Antimicrobial resistance, virulence factors, and genotypes of Enterococcus faecalis and Enterococcus faecium clinical isolates in Northern Japan: Identification of optrA in ST480 E. faecalis","volume":"12","author":"Aung MS","year":"2023","unstructured":"Aung MS, , Urushibara N, , Kawaguchiya M, et al. Antimicrobial resistance, virulence factors, and genotypes of Enterococcus faecalis and Enterococcus faecium clinical isolates in Northern Japan: Identification of optrA in ST480 E. faecalis. Antibiotics (Basel), 2023; 12(1):108; doi: 10.3390\/antibiotics12010108","journal-title":"Antibiotics (Basel)"},{"issue":"19","key":"e_1_3_5_49_2","doi-asserted-by":"crossref","first-page":"5964","DOI":"10.1128\/JB.00352-09","article-title":"Integrative and sequence characteristics of a novel genetic element, ICE6013, in Staphylococcus aureus","volume":"191","author":"Smyth DS","year":"2009","unstructured":"Smyth DS, , Robinson DA. Integrative and sequence characteristics of a novel genetic element, ICE6013, in Staphylococcus aureus. J Bacteriol, 2009; 191(19):5964\u20135975; doi: 10.1128\/JB.00352-09","journal-title":"J Bacteriol"},{"key":"e_1_3_5_50_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2180-7-99"},{"key":"e_1_3_5_51_2","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.jgar.2022.01.011","article-title":"Predominance of ST8 and CC1\/spa-t1784 methicillin-resistant Staphylococcus aureus isolates in Japan and their genomic characteristics","volume":"28","author":"Ogura K","year":"2022","unstructured":"Ogura K, , Kaji D, , Sasaki M, et al. Predominance of ST8 and CC1\/spa-t1784 methicillin-resistant Staphylococcus aureus isolates in Japan and their genomic characteristics. J Glob Antimicrob Resist, 2022; 28:195\u2013202; doi: 10.1016\/j.jgar.2022.01.011","journal-title":"J Glob Antimicrob Resist"},{"issue":"1","key":"e_1_3_5_52_2","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1080\/00313020701716276","article-title":"Clinical features, epidemiology, antimicrobial resistance, and exotoxin genes (including that of Panton-Valentine Leukocidin) of gentamicin-susceptible methicillin-resistant Staphylococcus aureus (GS-MRSA) isolated at a paediatric teaching hospital in New South Wales, Australia","volume":"40","author":"Gubbay JB","year":"2008","unstructured":"Gubbay JB, , Gosbell IB, , Barbagiannakos T, et al. Clinical features, epidemiology, antimicrobial resistance, and exotoxin genes (including that of Panton-Valentine Leukocidin) of gentamicin-susceptible methicillin-resistant Staphylococcus aureus (GS-MRSA) isolated at a paediatric teaching hospital in New South Wales, Australia. Pathology, 2008; 40(1):64\u201371; doi: 10.1080\/00313020701716276","journal-title":"Pathology"},{"issue":"4","key":"e_1_3_5_53_2","doi-asserted-by":"crossref","first-page":"e17936","DOI":"10.1371\/journal.pone.0017936","article-title":"A field guide to pandemic, epidemic and sporadic clones of methicillin-resistant Staphylococcus aureus","volume":"6","author":"Monecke S","year":"2011","unstructured":"Monecke S, , Coombs G, , Shore AC. A field guide to pandemic, epidemic and sporadic clones of methicillin-resistant Staphylococcus aureus. PLoS One, 2011; 6(4):e17936; doi: 10.1371\/journal.pone.0017936","journal-title":"PLoS One"},{"issue":"11","key":"e_1_3_5_54_2","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.3390\/antibiotics10111293","article-title":"Outcomes and future prospect of Japan's National Action Plan on antimicrobial resistance (2016\u20132020)","volume":"10","author":"Gu Y","year":"2021","unstructured":"Gu Y, , Fujitomo Y, , Ohmagari N. Outcomes and future prospect of Japan's National Action Plan on antimicrobial resistance (2016\u20132020). Antibiotics (Basel), 2021; 10(11):1293; doi: 10.3390\/antibiotics10111293","journal-title":"Antibiotics (Basel)"},{"issue":"1","key":"e_1_3_5_55_2","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1093\/jac\/dkaa404","article-title":"The molecular epidemiology of methicillin-resistant Staphylococcus aureus (MRSA) in the Czech Republic","volume":"76","author":"Tkadlec J","year":"2021","unstructured":"Tkadlec J, , Capek V, , Brajerova M, et al. The molecular epidemiology of methicillin-resistant Staphylococcus aureus (MRSA) in the Czech Republic. J Antimicrob Chemother, 2021; 76(1):55\u201364. doi: 10.1093\/jac\/dkaa404","journal-title":"J Antimicrob Chemother"},{"issue":"4","key":"e_1_3_5_56_2","doi-asserted-by":"crossref","first-page":"e0126423","DOI":"10.1128\/spectrum.01264-23","article-title":"Epidemiology of methicillin-resistant Staphylococcus aureus in Slovakia, 2020\u2014Emergence of an epidemic USA300 clone in community and hospitals","volume":"11","author":"Tkadlec J","year":"2023","unstructured":"Tkadlec J, , Le AV, , Brajerova M, et al. Epidemiology of methicillin-resistant Staphylococcus aureus in Slovakia, 2020\u2014Emergence of an epidemic USA300 clone in community and hospitals. Microbiol Spectr, 2023; 11(4):e0126423. doi: 10.1128\/spectrum.01264-23","journal-title":"Microbiol Spectr"},{"issue":"5","key":"e_1_3_5_57_2","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1007\/s10156-010-0087-z","article-title":"Spread of the community-acquired methicillin-resistant Staphylococcus aureus USA300 clone among family members in Japan","volume":"16","author":"Yabe S","year":"2010","unstructured":"Yabe S, , Takano T, , Higuchi W, et al. Spread of the community-acquired methicillin-resistant Staphylococcus aureus USA300 clone among family members in Japan. J Infect Chemother, 2010; 16(5):372\u2013374; doi: 10.1007\/s10156-010-0087-z","journal-title":"J Infect Chemother"},{"issue":"1","key":"e_1_3_5_58_2","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.diagmicrobio.2018.11.016","article-title":"Identification and detection of USA300 methicillin-resistant Staphylococcus aureus clones with a partial deletion in the ccrB2 gene on the type IV SCCmec element","volume":"94","author":"Takadama S","year":"2019","unstructured":"Takadama S, , Nakaminami H, , Takii T, et al. Identification and detection of USA300 methicillin-resistant Staphylococcus aureus clones with a partial deletion in the ccrB2 gene on the type IV SCCmec element. Diagn Microbiol Infect Dis, 2019; 94(1):86\u201387; doi: 10.1016\/j.diagmicrobio.2018.11.016","journal-title":"Diagn Microbiol Infect Dis"},{"issue":"1","key":"e_1_3_5_59_2","doi-asserted-by":"crossref","first-page":"8322","DOI":"10.1038\/s41598-023-35171-y","article-title":"Emergence of community-associated methicillin-resistant Staphylococcus aureus \u03a8USA300 among Japanese people with HIV, resulted from stepwise mutations in 2010s","volume":"13","author":"Shinohara K","year":"2023","unstructured":"Shinohara K, , Uehara Y, , Teruya K, et al. Emergence of community-associated methicillin-resistant Staphylococcus aureus \u03a8USA300 among Japanese people with HIV, resulted from stepwise mutations in 2010s. Sci Rep, 2023; 13(1):8322; doi: 10.1038\/s41598-023-35171-y","journal-title":"Sci Rep"},{"issue":"11","key":"e_1_3_5_60_2","doi-asserted-by":"crossref","first-page":"3131","DOI":"10.1093\/jac\/dkaa313","article-title":"A novel community-acquired MRSA clone, USA300-LV\/J, uniquely evolved in Japan","volume":"75","author":"Takadama S","year":"2020","unstructured":"Takadama S, , Nakaminami H, , Kaneko H, et al. A novel community-acquired MRSA clone, USA300-LV\/J, uniquely evolved in Japan. J Antimicrob Chemother, 2020; 75(11):3131\u20133134; doi: 10.1093\/jac\/dkaa313","journal-title":"J Antimicrob Chemother"},{"key":"e_1_3_5_61_2","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.ijregi.2023.05.006","article-title":"Acute osteomyelitis\/septic pulmonary embolism associated with familial infections caused by PVL-positive ST6562 MRSA-IVa, a presumptive variant of USA300 clone","volume":"8","author":"Harada N","year":"2023","unstructured":"Harada N, , Togashi A, , Aung MS, et al. Acute osteomyelitis\/septic pulmonary embolism associated with familial infections caused by PVL-positive ST6562 MRSA-IVa, a presumptive variant of USA300 clone. IJID Regions, 2023; 8:16\u201318; doi: 10.1016\/j.ijregi.2023.05.006","journal-title":"IJID Regions"},{"issue":"11","key":"e_1_3_5_62_2","doi-asserted-by":"crossref","first-page":"1316","DOI":"10.3390\/antibiotics10111316","article-title":"Antimicrobial resistance and molecular epidemiological characteristics of methicillin-resistant and susceptible staphylococcal isolates from oral cavity of dental patients and staff in northern Japan","volume":"10","author":"Hirose M","year":"2021","unstructured":"Hirose M, , Aung MS, , Fukuda A, et al. Antimicrobial resistance and molecular epidemiological characteristics of methicillin-resistant and susceptible staphylococcal isolates from oral cavity of dental patients and staff in northern Japan. Antibiotics (Basel), 2021; 10(11):1316; doi: 10.3390\/antibiotics10111316","journal-title":"Antibiotics (Basel)"},{"issue":"8","key":"e_1_3_5_63_2","doi-asserted-by":"crossref","first-page":"849","DOI":"10.3390\/pathogens11080849","article-title":"Genetic characterization of Staphylococcus aureus, Staphylococcus argenteus, and coagulase-negative staphylococci colonizing oral cavity and hand of healthy adults in northern Japan","volume":"11","author":"Hirose M","year":"2022","unstructured":"Hirose M, , Aung MS, , Fujita Y, et al. Genetic characterization of Staphylococcus aureus, Staphylococcus argenteus, and coagulase-negative staphylococci colonizing oral cavity and hand of healthy adults in northern Japan. Pathogens, 2022; 11(8):849; doi: 10.3390\/pathogens11080849","journal-title":"Pathogens"}],"container-title":["Microbial Drug Resistance"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1089\/mdr.2023.0203","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/mdr.2023.0203","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/mdr.2023.0203","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T20:41:17Z","timestamp":1777668077000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/full\/10.1089\/mdr.2023.0203"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1,29]]},"references-count":62,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2024,2]]}},"alternative-id":["10.1089\/mdr.2023.0203"],"URL":"https:\/\/doi.org\/10.1089\/mdr.2023.0203","relation":{},"ISSN":["1076-6294","1931-8448"],"issn-type":[{"value":"1076-6294","type":"print"},{"value":"1931-8448","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1,29]]}}}