{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T14:59:30Z","timestamp":1783954770377,"version":"3.55.0"},"reference-count":50,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Microbial Drug Resistance"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:p>\n                    Candidiasis is a common fungal infection caused by\n                    <jats:italic toggle=\"yes\">Candida<\/jats:italic>\n                    species, with\n                    <jats:italic toggle=\"yes\">Candida albicans<\/jats:italic>\n                    being the most prevalent. Resistance to azole drugs, commonly used to treat\n                    <jats:italic toggle=\"yes\">Candida<\/jats:italic>\n                    infections, poses a significant challenge. Transcriptional activator candidate 1 (\n                    <jats:italic toggle=\"yes\">TAC1<\/jats:italic>\n                    ) gene has emerged as a key player in regulating drug resistance in\n                    <jats:italic toggle=\"yes\">C. albicans<\/jats:italic>\n                    . This review explores the structure and function of the\n                    <jats:italic toggle=\"yes\">TAC1<\/jats:italic>\n                    gene and its role in azole resistance. This gene encodes a transcription factor that controls the expression of genes involved in drug resistance, such as efflux pump genes (\n                    <jats:italic toggle=\"yes\">CDR1, CDR2, and MDR1<\/jats:italic>\n                    ) and\n                    <jats:italic toggle=\"yes\">ERG11<\/jats:italic>\n                    . Mutations in\n                    <jats:italic toggle=\"yes\">TAC1<\/jats:italic>\n                    can increase these genes\u2019 expression and confer resistance to azoles. Various\n                    <jats:italic toggle=\"yes\">TAC1<\/jats:italic>\n                    gene mutations, mostly gain-of-function mutations, have been identified, which upregulate\n                    <jats:italic toggle=\"yes\">CDR1<\/jats:italic>\n                    and\n                    <jats:italic toggle=\"yes\">CDR2<\/jats:italic>\n                    expression, resulting in azole resistance. Understanding the mechanisms of azole resistance mediated by the\n                    <jats:italic toggle=\"yes\">TAC1<\/jats:italic>\n                    gene is crucial for the strategies in the effective antifungal development pipeline.\n                  <\/jats:p>","DOI":"10.1089\/mdr.2023.0334","type":"journal-article","created":{"date-parts":[[2024,5,21]],"date-time":"2024-05-21T06:16:10Z","timestamp":1716272170000},"page":"288-296","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":10,"title":["The\n                    <i>TAC1<\/i>\n                    Gene in\n                    <i>Candida albicans<\/i>\n                    : Structure, Function, and Role in Azole Resistance: A Mini-Review"],"prefix":"10.1177","volume":"30","author":[{"given":"Amir Hossein","family":"Mahdizade","sequence":"first","affiliation":[{"name":"Department of Medical Genetics, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran."},{"name":"Student Research Committee, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akbar","family":"Hoseinnejad","sequence":"additional","affiliation":[{"name":"Student Research Committee, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran."},{"name":"Department of Medical Mycology, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mona","family":"Ghazanfari","sequence":"additional","affiliation":[{"name":"Invasive Fungi Research Center, Communicable Diseases Institute, Mazandaran University of Medical Sciences, Sari, Iran."},{"name":"Department of Medical Mycology, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad Javad","family":"Boozhmehrani","sequence":"additional","affiliation":[{"name":"Student Research Committee, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran."},{"name":"Department of Medical Parasitology, Faculty of Medicine, Jundishapur University of Medical Sciences, Ahvaz, Iran."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seyed Sobhan","family":"Bahreiny","sequence":"additional","affiliation":[{"name":"Student Research Committee, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahdi","family":"Abastabar","sequence":"additional","affiliation":[{"name":"Invasive Fungi Research Center, Communicable Diseases Institute, Mazandaran University of Medical Sciences, Sari, Iran."},{"name":"Department of Medical Mycology, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberta","family":"Galbo","sequence":"additional","affiliation":[{"name":"Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Messina, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Letterio","family":"Giuffr\u00e8","sequence":"additional","affiliation":[{"name":"Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Messina, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iman","family":"Haghani","sequence":"additional","affiliation":[{"name":"Invasive Fungi Research Center, Communicable Diseases Institute, Mazandaran University of Medical Sciences, Sari, Iran."},{"name":"Department of Medical Mycology, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Orazio","family":"Romeo","sequence":"additional","affiliation":[{"name":"Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Messina, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,7,12]]},"reference":[{"key":"e_1_3_4_2_2","first-page":"358","article-title":"Identification and Antifungal Susceptibility Testing of Candida species isolated from Bronchoalveolar Lavage samples","author":"Armaki MT","year":"2014","unstructured":"Armaki MT, , Taghi M, , Abastabar M, et al. 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