{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T19:33:04Z","timestamp":1777923184869,"version":"3.51.4"},"reference-count":78,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Microbial Drug Resistance"],"published-print":{"date-parts":[[2024,8]]},"abstract":"\n The study determined the prevalence, antimicrobial resistant (AMR) determinants, and genetic characteristics of\n Escherichia coli<\/jats:italic>\n and\n Klebsiella pneumoniae<\/jats:italic>\n isolates from patients with diabetic foot infection (DFI) in a Tunisian hospital. A total of 26\n Escherichia<\/jats:italic>\n spp. and\n Klebsiella<\/jats:italic>\n spp. isolates were recovered and identified by MALDI-TOF-MS. Antimicrobial susceptibility testing, the detection of AMR determinants and Shiga-like toxin genes, phylogenetic grouping, and molecular typing were performed. Twelve\n E. coli<\/jats:italic>\n , 10\n K. pneumoniae<\/jats:italic>\n , 3\n K. oxytoca<\/jats:italic>\n , and 1\n E. hermanii<\/jats:italic>\n were isolated. A multidrug-resistant phenotype was detected in 65.4% of the isolates. About 30.8% of isolates were extended-spectrum \u03b2-lactamase (ESBL) producers and mainly carried\n \n bla\n CTX<\/jats:sub>\n <\/jats:italic>\n -M-15<\/jats:sub>\n and\n \n bla\n CTX<\/jats:sub>\n <\/jats:italic>\n -M-14<\/jats:sub>\n genes. One\n \n bla\n NDM<\/jats:sub>\n <\/jats:italic>\n -1<\/jats:sub>\n -producing\n K. pneumoniae-<\/jats:italic>\n ST1 strain was identified. Class 1 integrons were detected in 11 isolates and 5 gene cassette arrangements were noted:\n dfrA1+aadA1<\/jats:italic>\n (\n n<\/jats:italic>\n = 1),\n dfrA12+aadA2<\/jats:italic>\n (\n n<\/jats:italic>\n = 3), and\n dfrA17+aadA5<\/jats:italic>\n (\n n<\/jats:italic>\n = 1). Other non-\u03b2-lactam resistance genes detected were as follows (number of isolates):\n aac(3')-II<\/jats:italic>\n (3),\n aac(6')\u2013Ib-cr<\/jats:italic>\n (8),\n qnrB<\/jats:italic>\n (2),\n qnrS<\/jats:italic>\n (4),\n cmlA<\/jats:italic>\n (2),\n floR<\/jats:italic>\n (4),\n sul1<\/jats:italic>\n (11),\n sul2<\/jats:italic>\n (11), and\n sul3<\/jats:italic>\n (2). The phylogroup B1 was the most frequent (41.7%) among\n E. coli<\/jats:italic>\n , and two ESBL-producing isolates corresponded to the ST131-B2 lineage. The ESBL- and carbapenemase-producing\n Enterobacteriaceae<\/jats:italic>\n in DFIs are described for the first time in Tunisia.\n <\/jats:p>","DOI":"10.1089\/mdr.2023.0335","type":"journal-article","created":{"date-parts":[[2024,5,9]],"date-time":"2024-05-09T08:29:40Z","timestamp":1715243380000},"page":"341-349","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Surveillance of\n Enterobacteriaceae<\/i>\n from Diabetic Foot Infections in a Tunisian Hospital: Detection of\n E. coli-<\/i>\n ST131-\n bla<\/i>\n CTX-M-15<\/sub>\n and\n K. pneumoniae<\/i>\n -ST1-\n \n bla\n NDM-1<\/sub>\n <\/i>\n Strains"],"prefix":"10.1177","volume":"30","author":[{"given":"Ameni","family":"Arfaoui","sequence":"first","affiliation":[{"name":"Laboratory of Microorganisms and Active Biomolecules, Faculty of Sciences of Tunis, University of Tunis El Manar, Tunis, Tunisia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandra","family":"Mart\u00ednez-\u00c1lvarez","sequence":"additional","affiliation":[{"name":"Area of Biochemistry and Molecular Biology, OneHealth-UR Research Group, University of La Rioja, Logro\u00f1o, Spain."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Idris Nasir","family":"Abdullahi","sequence":"additional","affiliation":[{"name":"Area of Biochemistry and Molecular Biology, OneHealth-UR Research Group, University of La Rioja, Logro\u00f1o, Spain."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meha","family":"Fethi","sequence":"additional","affiliation":[{"name":"Laboratory of Microorganisms and Active Biomolecules, Faculty of Sciences of Tunis, University of Tunis El Manar, Tunis, Tunisia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noureddine","family":"Sayem","sequence":"additional","affiliation":[{"name":"Service of Biology, International Hospital Center Carthagene of Tunisia, Tunis, Tunisia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Salma Ben Khelifa","family":"Melki","sequence":"additional","affiliation":[{"name":"Service of Biology, International Hospital Center Carthagene of Tunisia, Tunis, Tunisia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hadda-Imene","family":"Ouzari","sequence":"additional","affiliation":[{"name":"Laboratory of Microorganisms and Active Biomolecules, Faculty of Sciences of Tunis, University of Tunis El Manar, Tunis, Tunisia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3709-1690","authenticated-orcid":false,"given":"Carmen","family":"Torres","sequence":"additional","affiliation":[{"name":"Area of Biochemistry and Molecular Biology, OneHealth-UR Research Group, University of La Rioja, Logro\u00f1o, Spain."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naouel","family":"Klibi","sequence":"additional","affiliation":[{"name":"Laboratory of Microorganisms and Active Biomolecules, Faculty of Sciences of Tunis, University of Tunis El Manar, Tunis, Tunisia."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2024,8,8]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2016.53"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcot.2021.01.017"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2019.08.229"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1089\/wound.2021.0118"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.semvascsurg.2019.02.001"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciad255"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24043913"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.4239\/wjd.v14.i6.680"},{"issue":"1","key":"e_1_3_4_10_2","doi-asserted-by":"crossref","first-page":"107","DOI":"10.21315\/mjms2019.26.1.10","article-title":"The significant association between polymicrobial diabetic foot infection and its severity and outcomes","volume":"26","author":"Hitam SAS","year":"2019","unstructured":"Hitam SAS, , Hassan SA, , Maning N. The significant association between polymicrobial diabetic foot infection and its severity and outcomes. Malays J Med Sci, 2019; 26(1):107\u2013114; doi: 10.21315\/mjms2019.26.1.10","journal-title":"Malays J Med Sci"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jiac.2015.12.007"},{"issue":"9","key":"e_1_3_4_12_2","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1080\/14787210.2020.1767593","article-title":"Point prevalence surveys of antimicrobial use: A systematic review and the implications","volume":"18","author":"Saleem Z","year":"2020","unstructured":"Saleem Z, , Hassali MA, , Godman B, et al. Point prevalence surveys of antimicrobial use: A systematic review and the implications. 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