{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T19:33:29Z","timestamp":1777923209934,"version":"3.51.4"},"reference-count":38,"publisher":"SAGE Publications","issue":"10","license":[{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Microbial Drug Resistance"],"published-print":{"date-parts":[[2024,10,1]]},"abstract":"<jats:p>\n                    Carbapenem-resistant\n                    <jats:italic toggle=\"yes\">Escherichia coli<\/jats:italic>\n                    pose a significant threat to global public health due to the dearth of available treatment options, resulting in infections with high mortality and morbidity. The study aimed to investigate the mechanism of carbapenem resistance in a carbapenem non-susceptible\n                    <jats:italic toggle=\"yes\">E. coli<\/jats:italic>\n                    isolate recovered from an urinary tract infection patient admitted to a tertiary referral hospital, through whole-genome sequencing using Illumina NovaSeq 6000 platform. Carbapenemase production followed by antibiotic susceptibility testing were performed following Clinical Laboratory Standard Institute guidelines.\u00a0Polymerase chain reaction targeting carbapenemase genes was performed followed by an investigation of horizontal transferability. The Center for Genomic Epidemiology database was used to analyze the sequenced data. ST2519\n                    <jats:italic toggle=\"yes\">E. coli<\/jats:italic>\n                    BJD_EC1808 with a genome size of 5.8 Mb harbored Col440I plasmid and a chromosomally located\n                    <jats:italic toggle=\"yes\">bla<\/jats:italic>\n                    <jats:sub>OXA-116<\/jats:sub>\n                    gene with an IS18 element upstream, along with multiple antibiotic resistance genes conferring clinical resistance toward beta-lactams, aminoglycosides, amphenicols, sulfonamides, tetracyclines, trimethoprim, rifampin, macrolide, and streptogramin antibiotics and antiseptics.\n                    <jats:italic toggle=\"yes\">E. coli<\/jats:italic>\n                    ST2519 harboring\n                    <jats:italic toggle=\"yes\">bla<\/jats:italic>\n                    <jats:sub>OXA-116<\/jats:sub>\n                    associated with a mobile genetic element exhibiting carbapenem resistance is a public health threat due to its limiting effect on the therapeutic usage of carbapenem and their dissemination into carbapenem non-susceptible phenotypes will contribute to carbapenem resistance burden and, therefore, warrants urgent monitoring and clinical intervention.\n                  <\/jats:p>","DOI":"10.1089\/mdr.2024.0022","type":"journal-article","created":{"date-parts":[[2024,8,2]],"date-time":"2024-08-02T13:30:18Z","timestamp":1722605418000},"page":"399-406","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Occurrence of\n                    <i>bla<\/i>\n                    <sub>OXA-116<\/sub>\n                    Carbapenemase in\n                    <i>Escherichia coli<\/i>\n                    ST2519 of Clinical Origin: A Report from Northeast India"],"prefix":"10.1177","volume":"30","author":[{"given":"Bhaskar Jyoti","family":"Das","sequence":"first","affiliation":[{"name":"Department of Microbiology, Assam University, Silchar, India."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K. Melson","family":"Singha","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Silchar Medical College and Hospital, Silchar, India."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jayalaxmi","family":"Wangkheimayum","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Assam University, Silchar, India."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Debadatta Dhar","family":"Chanda","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Silchar Medical College and Hospital, Silchar, India."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amitabha","family":"Bhattacharjee","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Assam University, Silchar, India."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2024,10,4]]},"reference":[{"key":"e_1_3_7_2_2","unstructured":"World Health Organization. Implementation manual to prevent and control the spread of carbapenem-resistant organisms at the national and health care facility level. Geneva CH; 2019 (WHO\/UHC\/SDS\/2019.6). Licence: CC BY-NC-SA 3.0 IGO. Available from: https:\/\/www.who.int\/publications\/i\/item\/WHO-UHC-SDS-2019-6 [Last accessed October25 2023]."},{"key":"e_1_3_7_3_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00001-07"},{"key":"e_1_3_7_4_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01512-08"},{"key":"e_1_3_7_5_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00117-13"},{"key":"e_1_3_7_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2004.01016.x"},{"key":"e_1_3_7_7_2","doi-asserted-by":"publisher","DOI":"10.4236\/ajmb.2022.123008"},{"key":"e_1_3_7_8_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12941-023-00635-6"},{"key":"e_1_3_7_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2006.03.023"},{"key":"e_1_3_7_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-6968.2006.00195.x"},{"key":"e_1_3_7_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/1469-0691.12143"},{"key":"e_1_3_7_12_2","doi-asserted-by":"publisher","DOI":"10.1586\/eri.11.28"},{"key":"e_1_3_7_13_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2021.614058"},{"key":"e_1_3_7_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/nyas.14918"},{"key":"e_1_3_7_15_2","unstructured":"Department of Biotechnology Ministry of Science & Technology Government of India. Indian Priority Pathogen List jointly developed by the DBT and WHO India Office. Available from: https:\/\/dbtindia.gov.in\/latest-announcement\/indian-priority-pathogen-list-jointly-developed-dbt-and-who-india-office [Last accessed October25 2023]."},{"key":"e_1_3_7_16_2","volume-title":"Performance Standards for Antimicrobial Susceptibility Testing","author":"Clinical and Laboratory Standards Institute","year":"2022","unstructured":"Clinical and Laboratory Standards Institute. Performance Standards for Antimicrobial Susceptibility Testing: 32nd edition M100-ED32. 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