{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T19:33:26Z","timestamp":1777923206201,"version":"3.51.4"},"reference-count":43,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Microbial Drug Resistance"],"published-print":{"date-parts":[[2024,9,1]]},"abstract":"<jats:p>\n                    The majority of\n                    <jats:italic toggle=\"yes\">Klebsiella pneumonia<\/jats:italic>\n                    isolates possess the extended-spectrum beta-lactamase (ESBL) enzymes. Therefore,\n                    <jats:italic toggle=\"yes\">K. pneumoniae<\/jats:italic>\n                    can easily develop drug resistance. How to effectively overcome the problem of drug resistance in\n                    <jats:italic toggle=\"yes\">K. pneumoniae<\/jats:italic>\n                    is still a research hotspot. This study aimed to compare the mutant prevention concentration (MPC) of ESBL-positive and ESBL-negative\n                    <jats:italic toggle=\"yes\">K. pneumoniae<\/jats:italic>\n                    isolated from orthopedic patients, which may provide a basis for the effective use of drugs to control the enrichment of resistance mutants of\n                    <jats:italic toggle=\"yes\">K. pneumoniae<\/jats:italic>\n                    . The MPC\n                    <jats:sub>90<\/jats:sub>\n                    values of 55 isolates of ESBL-positive\n                    <jats:italic toggle=\"yes\">K. pneumoniae<\/jats:italic>\n                    against 4 fluoroquinolones were 32 \u00b5g\/mL for levofloxacin and gatifloxacin, 16 \u00b5g\/mL for ciprofloxacin, and 4 \u00b5g\/mL for gemifloxacin. The selection index value was 8 for levofloxacin and ciprofloxacin and 2 for gemifloxacin and gatifloxacin, respectively. For ESBL-negative\n                    <jats:italic toggle=\"yes\">K. pneumoniae<\/jats:italic>\n                    isolates, the MPC\n                    <jats:sub>90<\/jats:sub>\n                    values were 16 \u00b5g\/mL for levofloxacin and ciprofloxacin, 4 \u00b5g\/mL for gemifloxacin, and 32 \u00b5g\/mL for gatifloxacin. The selection index value was 8 for levofloxacin and ciprofloxacin, 2 for gemifloxacin, and 4 for gatifloxacin. For the ESBL-positive\n                    <jats:italic toggle=\"yes\">K. pneumoniae<\/jats:italic>\n                    , the %T&gt;MIC\n                    <jats:sub>90<\/jats:sub>\n                    order was gemifloxacin &gt; levofloxacin &gt; ciprofloxacin &gt; gatifloxacin. For the ESBL-negative\n                    <jats:italic toggle=\"yes\">K. pneumoniae,<\/jats:italic>\n                    the %T&gt;MIC\n                    <jats:sub>90<\/jats:sub>\n                    order was levofloxacin &gt; gemifloxacin &gt; ciprofloxacin &gt; gatifloxacin. The mutant-preventing ability of gatifloxacin and gemifloxacin was the strongest among the 4 fluoroquinolones. So gemifloxacin may be the first choice of drug to treat\n                    <jats:italic toggle=\"yes\">K. pneumoniae<\/jats:italic>\n                    infection.\n                  <\/jats:p>","DOI":"10.1089\/mdr.2024.0023","type":"journal-article","created":{"date-parts":[[2024,7,17]],"date-time":"2024-07-17T18:22:32Z","timestamp":1721240552000},"page":"391-397","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Comparison of Mutant Prevention Concentrations of Fluoroquinolones Against ESBL-Positive and ESBL-Negative\n                    <i>Klebsiella pneumoniae<\/i>\n                    Isolates from Orthopedic Patients"],"prefix":"10.1177","volume":"30","author":[{"given":"Peng","family":"Zou","sequence":"first","affiliation":[{"name":"The Department of Orthopedics, Zhengzhou Seventh People\u2019s Hospital, Zhengzhou, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhiquan","family":"Chen","sequence":"additional","affiliation":[{"name":"The Department of Orthopedics, Zhengzhou Seventh People\u2019s Hospital, Zhengzhou, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jijun","family":"Tu","sequence":"additional","affiliation":[{"name":"The Department of Orthopedics, Zhengzhou Seventh People\u2019s Hospital, Zhengzhou, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinfeng","family":"Chen","sequence":"additional","affiliation":[{"name":"The Department of Orthopedics, Zhengzhou Seventh People\u2019s Hospital, Zhengzhou, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuejian","family":"Liu","sequence":"additional","affiliation":[{"name":"The Department of Orthopedics, Zhengzhou Seventh People\u2019s Hospital, Zhengzhou, 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