{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T10:00:24Z","timestamp":1789207224893,"version":"build-2803163510"},"reference-count":40,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Microbial Drug Resistance"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:p>\n                    <jats:italic toggle=\"yes\">Streptococcus anginosus<\/jats:italic>\n                    is an important cause of pyogenic infections, bacteremia, and chronic maxillary sinusitis. Mobile genetic elements (MGEs) play a key role in lateral gene transfer, resulting in broad transfer of antibiotic resistance genes (ARGs). However, studies on ARG-associated MGEs in\n                    <jats:italic toggle=\"yes\">S. anginosus<\/jats:italic>\n                    are still rare. To fill this gap, we used sequencing data from 11 clinical\n                    <jats:italic toggle=\"yes\">S. anginosus<\/jats:italic>\n                    to characterize their mobilome diversity through comparative analysis. We found 47 well-characterized MGEs, including 23 putative integrative and conjugative elements (ICEs), 16 prophages\/integrative mobilizable elements, and 8 composites. They were inserted into 16 positions, 4 of which were hot spots. A comprehensive analysis revealed that ARG-associated ICEs belong to four groups as follows: single serine integrases (ICE\n                    <jats:italic toggle=\"yes\">San<\/jats:italic>\n                    49.2), tyrosine integrases (ICE\n                    <jats:italic toggle=\"yes\">San<\/jats:italic>\n                    26.2), triple serine integrase ICEs (ICE\n                    <jats:italic toggle=\"yes\">San<\/jats:italic>\n                    195.1), and a putative transposon integrase (ICE\n                    <jats:italic toggle=\"yes\">San<\/jats:italic>\n                    49.1), all of which were similar to ICEs\/transposons widely distributed among other streptococci. The eight composites were composed of multiple ICEs or transposons through successive accretion events (tandem or\/and internal integration). In conclusion, we found that\n                    <jats:italic toggle=\"yes\">S. anginosus<\/jats:italic>\n                    accumulates a variety of ARG-associated ICE\/composites that may enable\n                    <jats:italic toggle=\"yes\">S. anginosus<\/jats:italic>\n                    to serve as an ARG-associated MGE repository for other streptococci. The analysis of composites here provides a paradigm to further study mobilome evolution.\n                  <\/jats:p>","DOI":"10.1089\/mdr.2024.0229","type":"journal-article","created":{"date-parts":[[2025,1,21]],"date-time":"2025-01-21T18:08:54Z","timestamp":1737482934000},"page":"52-63","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":7,"title":["Diversity and Evolution of the Mobilome Associated with Antibiotic Resistance Genes in\n                    <i>Streptococcus anginosus<\/i>"],"prefix":"10.1177","volume":"31","author":[{"given":"Yingting","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Critical Care Medicine, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taoran","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Sida","sequence":"additional","affiliation":[{"name":"Institute of Antibiotics, Huashan Hospital, Fudan University, Shanghai, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanting","family":"Zhu","sequence":"additional","affiliation":[{"name":"NHC Key Laboratory of Assisted Circulation, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China."},{"name":"Department of Cardiology, The Seventh Affiliated Hospital of Sun Yat-sen University, Shenzhen, China."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,2,12]]},"reference":[{"issue":"7","key":"e_1_3_7_2_2","doi-asserted-by":"crossref","first-page":"2506","DOI":"10.1099\/ijs.0.043232-0","article-title":"Taxonomy of the Anginosus group of the genus Streptococcus and description of Streptococcus anginosus subsp. whileyi subsp. nov. and Streptococcus constellatus subsp. viborgensis subsp. nov","volume":"63","author":"Jensen A","year":"2013","unstructured":"Jensen A, , Hoshino T, , Kilian M. Taxonomy of the Anginosus group of the genus Streptococcus and description of Streptococcus anginosus subsp. whileyi subsp. nov. and Streptococcus constellatus subsp. viborgensis subsp. nov. Int J Syst Evol Microbiol, 2013; 63(Pt 7):2506\u20132519; doi: 10.1099\/ijs.0.043232-0","journal-title":"Int J Syst Evol Microbiol"},{"key":"e_1_3_7_3_2","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.30.1.243-244.1992"},{"key":"e_1_3_7_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/omi.12056"},{"issue":"23","key":"e_1_3_7_5_2","doi-asserted-by":"crossref","first-page":"6783","DOI":"10.1016\/j.cell.2024.10.036","article-title":"Streptococcus anginosus promotes gastric inflammation, atrophy, and tumorigenesis in mice","volume":"187","author":"Fu K","year":"2024","unstructured":"Fu K, , Cheung AHK, , Wong CC, et al. Streptococcus anginosus promotes gastric inflammation, atrophy, and tumorigenesis in mice. Cell, 2024; 187(23):6783; doi: 10.1016\/j.cell.2024.10.036","journal-title":"Cell"},{"issue":"7","key":"e_1_3_7_6_2","doi-asserted-by":"crossref","first-page":"1933","DOI":"10.1053\/j.gastro.2022.02.015","article-title":"Fecal signatures of Streptococcus anginosus and Streptococcus constellatus for noninvasive screening and early warning of gastric cancer","volume":"162","author":"Zhou CB","year":"2022","unstructured":"Zhou CB, , Pan SY, , Jin P, et al. Fecal signatures of Streptococcus anginosus and Streptococcus constellatus for noninvasive screening and early warning of gastric cancer. Gastroenterology, 2022; 162(7):1933\u20131947.e18; doi: 10.1053\/j.gastro.2022.02.015","journal-title":"Gastroenterology"},{"issue":"5","key":"e_1_3_7_7_2","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.17305\/bb.2024.10705","article-title":"Streptococcus anginosus: A new pathogen of superficial gastritis, atrophic gastritis and gastric cancer","volume":"24","author":"Guo F","year":"2024","unstructured":"Guo F, , Li L, , Li L. Streptococcus anginosus: A new pathogen of superficial gastritis, atrophic gastritis and gastric cancer. Biomol Biomed, 2024; 24(5):1040\u20131043; doi: 10.17305\/bb.2024.10705","journal-title":"Biomol Biomed"},{"issue":"2","key":"e_1_3_7_8_2","first-page":"131","article-title":"[Macrolides, Lincosamides, Streptogramines (MLS): Mechanisms of action and resistance]","volume":"55","author":"Ungureanu V","year":"2010","unstructured":"Ungureanu V. [Macrolides, Lincosamides, Streptogramines (MLS): Mechanisms of action and resistance]. Bacteriol Virusol Parazitol Epidemiol, 2010; 55(2):131\u2013138.","journal-title":"Bacteriol Virusol Parazitol Epidemiol"},{"issue":"2","key":"e_1_3_7_9_2","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1128\/AAC.00781-08","article-title":"Genetic elements responsible for erythromycin resistance in streptococci","volume":"53","author":"Varaldo PE","year":"2009","unstructured":"Varaldo PE, , Montanari MP, , Giovanetti E. Genetic elements responsible for erythromycin resistance in streptococci. Antimicrob Agents Chemother, 2009; 53(2):343\u2013353; doi: 10.1128\/AAC.00781-08","journal-title":"Antimicrob Agents Chemother"},{"issue":"8","key":"e_1_3_7_10_2","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1038\/nrmicro2382","article-title":"Integrative and conjugative elements: Mosaic mobile genetic elements enabling dynamic lateral gene flow","volume":"8","author":"Wozniak RA","year":"2010","unstructured":"Wozniak RA, , Waldor MK. Integrative and conjugative elements: Mosaic mobile genetic elements enabling dynamic lateral gene flow. Nat Rev Microbiol, 2010; 8(8):552\u2013563; doi: 10.1038\/nrmicro2382","journal-title":"Nat Rev Microbiol"},{"issue":"9","key":"e_1_3_7_11_2","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1038\/nrmicro1235","article-title":"Mobile genetic elements: The agents of open source evolution","volume":"3","author":"Frost LS","year":"2005","unstructured":"Frost LS, , Leplae R, , Summers AO, et al. Mobile genetic elements: The agents of open source evolution. Nat Rev Microbiol, 2005; 3(9):722\u2013732; doi: 10.1038\/nrmicro1235","journal-title":"Nat Rev Microbiol"},{"key":"e_1_3_7_12_2","first-page":"1483","article-title":"New insights into the classification and integration specificity of Streptococcus integrative conjugative elements through extensive genome exploration","volume":"6","author":"Ambroset C","year":"2015","unstructured":"Ambroset C, , Coluzzi C, , Guedon G, et al. New insights into the classification and integration specificity of Streptococcus integrative conjugative elements through extensive genome exploration. Front Microbiol, 2015; 6:1483; doi: 10.3389\/fmicb.2015.01483","journal-title":"Front Microbiol"},{"key":"e_1_3_7_13_2","doi-asserted-by":"crossref","first-page":"55","DOI":"10.3389\/fmicb.2016.00055","article-title":"Comparative genomic analysis of the ICESa2603 family ICEs and spread of erm(B)- and tet(O)-Carrying Transferable 89K-Subtype ICEs in Swine and Bovine isolates in China","volume":"7","author":"Huang J","year":"2016","unstructured":"Huang J, , Liang Y, , Guo D, et al. Comparative genomic analysis of the ICESa2603 family ICEs and spread of erm(B)- and tet(O)-Carrying Transferable 89K-Subtype ICEs in Swine and Bovine isolates in China. Front Microbiol, 2016; 7:55; doi: 10.3389\/fmicb.2016.00055","journal-title":"Front Microbiol"},{"issue":"8","key":"e_1_3_7_14_2","doi-asserted-by":"crossref","first-page":"2066","DOI":"10.1093\/jac\/dkad205","article-title":"Characterization of an optrA-harbouring unconventional circularizable structure located on a novel ICESa2603 family-like integrative and conjugative element ICESsuHN38 in Streptococcus suis","volume":"78","author":"Yang Q","year":"2023","unstructured":"Yang Q, , Zhu Y, , Schwarz S, et al. Characterization of an optrA-harbouring unconventional circularizable structure located on a novel ICESa2603 family-like integrative and conjugative element ICESsuHN38 in Streptococcus suis. J Antimicrob Chemother, 2023; 78(8):2066\u20132069; doi: 10.1093\/jac\/dkad205","journal-title":"J Antimicrob Chemother"},{"issue":"1","key":"e_1_3_7_15_2","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1128\/AAC.00499-09","article-title":"Phim46.1, the main Streptococcus pyogenes element carrying mef(A) and tet(O) genes","volume":"54","author":"Brenciani A","year":"2010","unstructured":"Brenciani A, , Bacciaglia A, , Vignaroli C, et al. Phim46.1, the main Streptococcus pyogenes element carrying mef(A) and tet(O) genes. Antimicrob Agents Chemother, 2010; 54(1):221\u2013229; doi: 10.1128\/AAC.00499-09","journal-title":"Antimicrob Agents Chemother"},{"issue":"3","key":"e_1_3_7_16_2","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1093\/jac\/dkv408","article-title":"Macrolide resistance gene erm(TR) and erm(TR)-carrying genetic elements in Streptococcus agalactiae: Characterization of ICESagTR7, a new composite element containing IMESp2907","volume":"71","author":"Mingoia M","year":"2016","unstructured":"Mingoia M, , Morici E, , Marini E, et al. Macrolide resistance gene erm(TR) and erm(TR)-carrying genetic elements in Streptococcus agalactiae: Characterization of ICESagTR7, a new composite element containing IMESp2907. J Antimicrob Chemother, 2016; 71(3):593\u2013600; doi: 10.1093\/jac\/dkv408","journal-title":"J Antimicrob Chemother"},{"key":"e_1_3_7_17_2","volume-title":"Performance Standards for Antimicrobial Susceptibility Testing: 29th Informational Supplement","author":"Clinical and Laboratory Standards Institute (CLSI)","year":"2019","unstructured":"Clinical and Laboratory Standards Institute (CLSI). Performance Standards for Antimicrobial Susceptibility Testing: 29th Informational Supplement. CLSI: Wayne, PA; 2019. M100Ed29."},{"key":"e_1_3_7_18_2","doi-asserted-by":"publisher","DOI":"10.1101\/gr.074492.107"},{"key":"e_1_3_7_19_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btu153"},{"issue":"6","key":"e_1_3_7_20_2","doi-asserted-by":"crossref","DOI":"10.1128\/genomeA.01440-15","article-title":"Complete genome sequence of Streptococcus anginosus J4211, a clinical isolate","volume":"3","author":"Rahman M","year":"2015","unstructured":"Rahman M, , Nguyen SV, , McCullor KA, et al. Complete genome sequence of Streptococcus anginosus J4211, a clinical isolate. Genome Announc, 2015; 3(6); doi: 10.1128\/genomeA.01440-15","journal-title":"Genome Announc"},{"key":"e_1_3_7_21_2","doi-asserted-by":"publisher","DOI":"10.1101\/gr.2289704"},{"issue":"20","key":"e_1_3_7_22_2","doi-asserted-by":"crossref","first-page":"5839","DOI":"10.1093\/nar\/gkl732","article-title":"Phage_Finder: Automated identification and classification of prophage regions in complete bacterial genome sequences","volume":"34","author":"Fouts DE","year":"2006","unstructured":"Fouts DE. Phage_Finder: Automated identification and classification of prophage regions in complete bacterial genome sequences. Nucleic Acids Res, 2006; 34(20):5839\u20135851; doi: 10.1093\/nar\/gkl732","journal-title":"Nucleic Acids Res"},{"key":"e_1_3_7_23_2","doi-asserted-by":"crossref","first-page":"D621","DOI":"10.1093\/nar\/gkr846","article-title":"ICEberg: A web-based resource for integrative and conjugative elements found in Bacteria","volume":"40","author":"Bi D","year":"2012","unstructured":"Bi D, , Xu Z, , Harrison EM, et al. ICEberg: A web-based resource for integrative and conjugative elements found in Bacteria. Nucleic Acids Res, 2012; 40(Database issue):D621\u2013D626; doi: 10.1093\/nar\/gkr846","journal-title":"Nucleic Acids Res"},{"key":"e_1_3_7_24_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dks261"},{"key":"e_1_3_7_25_2","doi-asserted-by":"publisher","DOI":"10.1089\/mdr.2023.0342"},{"issue":"2","key":"e_1_3_7_26_2","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1128\/AAC.01081-07","article-title":"New genetic element carrying the erythromycin resistance determinant erm(TR) in Streptococcus pneumoniae","volume":"52","author":"Camilli R","year":"2008","unstructured":"Camilli R, , Del Grosso M, , Iannelli F, et al. New genetic element carrying the erythromycin resistance determinant erm(TR) in Streptococcus pneumoniae. Antimicrob Agents Chemother, 2008; 52(2):619\u2013625; doi: 10.1128\/AAC.01081-07","journal-title":"Antimicrob Agents Chemother"},{"issue":"8","key":"e_1_3_7_27_2","doi-asserted-by":"crossref","first-page":"e800","DOI":"10.1371\/journal.pone.0000800","article-title":"Contribution of exogenous genetic elements to the group A Streptococcus metagenome","volume":"2","author":"Beres SB","year":"2007","unstructured":"Beres SB, , Musser JM. Contribution of exogenous genetic elements to the group A Streptococcus metagenome. PLoS One, 2007; 2(8):e800; doi: 10.1371\/journal.pone.0000800","journal-title":"PLoS One"},{"key":"e_1_3_7_28_2","doi-asserted-by":"crossref","first-page":"109009","DOI":"10.1016\/j.vetmic.2021.109009","article-title":"Nonconservative integration and diversity of a new family of integrative and conjugative elements associated with antibiotic resistance in zoonotic pathogen Streptococcus suis","volume":"254","author":"Yi S","year":"2021","unstructured":"Yi S, , Huang J, , Hu X, et al. Nonconservative integration and diversity of a new family of integrative and conjugative elements associated with antibiotic resistance in zoonotic pathogen Streptococcus suis. Vet Microbiol, 2021; 254:109009; doi: 10.1016\/j.vetmic.2021.109009","journal-title":"Vet Microbiol"},{"key":"e_1_3_7_29_2","doi-asserted-by":"crossref","first-page":"118","DOI":"10.3389\/fcimb.2016.00118","article-title":"Evolution and diversity of the antimicrobial resistance associated mobilome in Streptococcus suis: A probable mobile genetic elements reservoir for other streptococci","volume":"6","author":"Huang J","year":"2016","unstructured":"Huang J, , Ma J, , Shang K, et al. Evolution and diversity of the antimicrobial resistance associated mobilome in Streptococcus suis: A probable mobile genetic elements reservoir for other streptococci. Front Cell Infect Microbiol, 2016; 6:118; doi: 10.3389\/fcimb.2016.00118","journal-title":"Front Cell Infect Microbiol"},{"key":"e_1_3_7_30_2","doi-asserted-by":"crossref","first-page":"1921","DOI":"10.3389\/fmicb.2017.01921","article-title":"ICESag37, a novel integrative and conjugative element carrying antimicrobial resistance genes and potential virulence factors in Streptococcus agalactiae","volume":"8","author":"Zhou K","year":"2017","unstructured":"Zhou K, , Xie L, , Han L, et al. ICESag37, a novel integrative and conjugative element carrying antimicrobial resistance genes and potential virulence factors in Streptococcus agalactiae. Front Microbiol, 2017; 8:1921; doi: 10.3389\/fmicb.2017.01921","journal-title":"Front Microbiol"},{"issue":"1","key":"e_1_3_7_31_2","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1128\/AAC.05352-11","article-title":"ICESp2905, the erm(TR)-tet(O) element of Streptococcus pyogenes, is formed by two independent integrative and conjugative elements","volume":"56","author":"Giovanetti E","year":"2012","unstructured":"Giovanetti E, , Brenciani A, , Tiberi E, et al. ICESp2905, the erm(TR)-tet(O) element of Streptococcus pyogenes, is formed by two independent integrative and conjugative elements. Antimicrob Agents Chemother, 2012; 56(1):591\u2013594; doi: 10.1128\/AAC.05352-11","journal-title":"Antimicrob Agents Chemother"},{"issue":"9","key":"e_1_3_7_32_2","doi-asserted-by":"crossref","first-page":"1979","DOI":"10.1128\/JB.01745-12","article-title":"Modular evolution of TnGBSs, a new family of integrative and conjugative elements associating insertion sequence transposition, plasmid replication, and conjugation for their spreading","volume":"195","author":"Guerillot R","year":"2013","unstructured":"Guerillot R, , Da Cunha V, , Sauvage E, et al. Modular evolution of TnGBSs, a new family of integrative and conjugative elements associating insertion sequence transposition, plasmid replication, and conjugation for their spreading. J Bacteriol, 2013; 195(9):1979\u20131990; doi: 10.1128\/JB.01745-12","journal-title":"J Bacteriol"},{"issue":"7","key":"e_1_3_7_33_2","doi-asserted-by":"crossref","first-page":"3906","DOI":"10.1128\/AAC.03082-15","article-title":"ICESpy009, a Conjugative Genetic Element Carrying mef(E) in Streptococcus pyogenes","volume":"60","author":"Del Grosso M","year":"2016","unstructured":"Del Grosso M, , Camilli R, , Rizzi E, et al. ICESpy009, a Conjugative Genetic Element Carrying mef(E) in Streptococcus pyogenes. Antimicrob Agents Chemother, 2016; 60(7):3906\u20133912; doi: 10.1128\/AAC.03082-15","journal-title":"Antimicrob Agents Chemother"},{"issue":"4","key":"e_1_3_7_34_2","doi-asserted-by":"crossref","first-page":"e01386","DOI":"10.1128\/mBio.01386-14","article-title":"vanG element insertions within a conserved chromosomal site conferring vancomycin resistance to Streptococcus agalactiae and Streptococcus anginosus","volume":"5","author":"Srinivasan V","year":"2014","unstructured":"Srinivasan V, , Metcalf BJ, , Knipe KM, et al. vanG element insertions within a conserved chromosomal site conferring vancomycin resistance to Streptococcus agalactiae and Streptococcus anginosus. mBio, 2014; 5(4):e01386\u2013e01414; doi: 10.1128\/mBio.01386-14","journal-title":"mBio"},{"issue":"19","key":"e_1_3_7_35_2","doi-asserted-by":"crossref","first-page":"12391","DOI":"10.1073\/pnas.182380799","article-title":"Complete genome sequence and comparative genomic analysis of an emerging human pathogen, serotype V Streptococcus agalactiae","volume":"99","author":"Tettelin H","year":"2002","unstructured":"Tettelin H, , Masignani V, , Cieslewicz MJ, et al. Complete genome sequence and comparative genomic analysis of an emerging human pathogen, serotype V Streptococcus agalactiae. Proc Natl Acad Sci U S A, 2002; 99(19):12391\u201312396; doi: 10.1073\/pnas.182380799","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"5","key":"e_1_3_7_36_2","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1093\/jac\/dkm331","article-title":"Demonstration of in\u00a0vivo transfer of doxycycline resistance mediated by a novel transposon","volume":"60","author":"Warburton PJ","year":"2007","unstructured":"Warburton PJ, , Palmer RM, , Munson MA, et al. Demonstration of in\u00a0vivo transfer of doxycycline resistance mediated by a novel transposon. J Antimicrob Chemother, 2007; 60(5):973\u2013980; doi: 10.1093\/jac\/dkm331","journal-title":"J Antimicrob Chemother"},{"issue":"1","key":"e_1_3_7_37_2","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.vetmic.2015.04.013","article-title":"Recombination between Streptococcus suis ICESsu32457 and Streptococcus agalactiae ICESa2603 yields a hybrid ICE transferable to Streptococcus pyogenes","volume":"178","author":"Marini E","year":"2015","unstructured":"Marini E, , Palmieri C, , Magi G, et al. Recombination between Streptococcus suis ICESsu32457 and Streptococcus agalactiae ICESa2603 yields a hybrid ICE transferable to Streptococcus pyogenes. Vet Microbiol, 2015; 178(1\u20132):99\u2013104; doi: 10.1016\/j.vetmic.2015.04.013","journal-title":"Vet Microbiol"},{"issue":"4","key":"e_1_3_7_38_2","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1099\/mic.0.26883-0","article-title":"Evolution of genomic islands by deletion and tandem accretion by site-specific recombination: ICESt1-related elements from Streptococcus thermophilus","volume":"150","author":"Pavlovic G","year":"2004","unstructured":"Pavlovic G, , Burrus V, , Gintz B, et al. Evolution of genomic islands by deletion and tandem accretion by site-specific recombination: ICESt1-related elements from Streptococcus thermophilus. Microbiology (Reading), 2004; 150(Pt 4):759\u2013774; doi: 10.1099\/mic.0.26883-0","journal-title":"Microbiology (Reading)"},{"issue":"3","key":"e_1_3_7_39_2","article-title":"Genomic analysis reveals new integrative conjugal elements and transposons in GBS conferring antimicrobial resistance","volume":"12","author":"Khan UB","year":"2023","unstructured":"Khan UB, , Portal EAR, , Sands K, et al. Genomic analysis reveals new integrative conjugal elements and transposons in GBS conferring antimicrobial resistance. Antibiotics (Basel), 2023; 12(3); doi: 10.3390\/antibiotics12030544","journal-title":"Antibiotics (Basel)"},{"issue":"10","key":"e_1_3_7_40_2","doi-asserted-by":"crossref","first-page":"5886","DOI":"10.1128\/AAC.03638-14","article-title":"Tn5253 family integrative and conjugative elements carrying mef(I) and catQ determinants in Streptococcus pneumoniae and Streptococcus pyogenes","volume":"58","author":"Mingoia M","year":"2014","unstructured":"Mingoia M, , Morici E, , Morroni G, et al. Tn5253 family integrative and conjugative elements carrying mef(I) and catQ determinants in Streptococcus pneumoniae and Streptococcus pyogenes. Antimicrob Agents Chemother, 2014; 58(10):5886\u20135893; doi: 10.1128\/AAC.03638-14","journal-title":"Antimicrob Agents Chemother"},{"issue":"4","key":"e_1_3_7_41_2","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1128\/JB.183.4.1124-1132.2001","article-title":"Formation of chromosomal tandem arrays of the SXT element and R391, two conjugative chromosomally integrating elements that share an attachment site","volume":"183","author":"Hochhut B","year":"2001","unstructured":"Hochhut B, , Beaber JW, , Woodgate R, et al. Formation of chromosomal tandem arrays of the SXT element and R391, two conjugative chromosomally integrating elements that share an attachment site. J Bacteriol, 2001; 183(4):1124\u20131132; doi: 10.1128\/JB.183.4.1124-1132.2001","journal-title":"J Bacteriol"}],"container-title":["Microbial Drug Resistance"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1089\/mdr.2024.0229","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/mdr.2024.0229","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/mdr.2024.0229","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T20:41:56Z","timestamp":1777668116000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/full\/10.1089\/mdr.2024.0229"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2]]},"references-count":40,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,2]]}},"alternative-id":["10.1089\/mdr.2024.0229"],"URL":"https:\/\/doi.org\/10.1089\/mdr.2024.0229","relation":{},"ISSN":["1076-6294","1931-8448"],"issn-type":[{"value":"1076-6294","type":"print"},{"value":"1931-8448","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2]]}}}