{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T18:30:19Z","timestamp":1790188219065,"version":"4.1.0"},"reference-count":36,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Microbial Drug Resistance"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:p>\n                    Methicillin-resistant\n                    <jats:italic toggle=\"yes\">Staphylococcus aureus<\/jats:italic>\n                    (MRSA) infections pose serious treatment challenges, particularly in peritoneal dialysis patients due to their increased susceptibility to infections and antibiotic resistance. Vancomycin, a standard antibiotic treatment for MRSA, is currently being compromised due to the evolution of multidrug-resistant microorganisms. Therefore, there is an urgent need for alternative therapeutic strategies to obstruct the increasing antibiotic resistance and bacterial biofilm formation. The present study explores curcumin, a natural bioactive compound possessing antimicrobial and anti-inflammatory properties, as a potential therapeutic for MRSA. The standard optical density method confirmed the antibacterial activity of curcumin against\n                    <jats:italic toggle=\"yes\">Staphylococcus aureus<\/jats:italic>\n                    (MTCC-3160). Furthermore, we investigated the impact of curcumin on bacterial metabolism. Metabolic analysis of\n                    <jats:italic toggle=\"yes\">S. aureus<\/jats:italic>\n                    culture media over a 20-h period revealed that curcumin exerts bacteriostatic effects by inhibiting specific metabolic pathways, potentially linked to energy and sugar metabolism. Furthermore, the synergistic effect of curcumin combined with vancomycin was assessed against 20 clinical MRSA strains using the broth microdilution method. The results demonstrated that curcumin enhanced the antibacterial activity of vancomycin in 17 strains by reducing its minimum inhibitory concentration (MIC) significantly. The MIC of curcumin and vancomycin has been found to decrease significantly when used in combination, with curcumin\u2019s MIC decreased to as low as 0.5 \u00b5g\/mL and vancomycin\u2019s MIC to 0.5 \u00b5g\/mL for all strains. Synergistic effects were seen in 17 out of 20 strains, having fractional inhibitory concentration index values between 0.04 and 0.56. These findings suggest that curcumin\u2013vancomycin combination therapy could offer an effective treatment strategy for MRSA infections which may combat antibiotic resistance and reduce treatment-related toxicity.\n                  <\/jats:p>","DOI":"10.1089\/mdr.2024.0231","type":"journal-article","created":{"date-parts":[[2025,2,14]],"date-time":"2025-02-14T10:04:51Z","timestamp":1739527491000},"page":"65-74","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Synergistic Potential of Curcumin\u2013Vancomycin Therapy in Combating Methicillin-Resistant\n                    <i>Staphylococcus aureus<\/i>\n                    Infections: Exploring a Novel Approach to Address Antibiotic Resistance and Toxicity"],"prefix":"10.1177","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4158-2241","authenticated-orcid":false,"given":"Anupam","family":"Guleria","sequence":"first","affiliation":[{"name":"Department of Nephrology, SGPGIMS, Lucknow, Uttar Pradesh, India."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nida","family":"Fatima","sequence":"additional","affiliation":[{"name":"Department of Microbiology, SGPGIMS, Lucknow, Uttar Pradesh, India."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anuj","family":"Shukla","sequence":"additional","affiliation":[{"name":"Department of Advanced Spectroscopy and Imaging, Centre of Biomedical Research (CBMR), SGPGIMS Campus, Lucknow, India."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ritu","family":"Raj","sequence":"additional","affiliation":[{"name":"Department of Advanced Spectroscopy and Imaging, Centre of Biomedical Research (CBMR), SGPGIMS Campus, Lucknow, India."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chinmoy","family":"Sahu","sequence":"additional","affiliation":[{"name":"Department of Microbiology, SGPGIMS, Lucknow, Uttar Pradesh, India."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Narayan","family":"Prasad","sequence":"additional","affiliation":[{"name":"Department of Nephrology, SGPGIMS, Lucknow, Uttar Pradesh, India."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-6954-3232","authenticated-orcid":false,"given":"Ashutosh","family":"Pathak","sequence":"additional","affiliation":[{"name":"Department of Microbiology, SGPGIMS, Lucknow, Uttar Pradesh, India."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8079-6739","authenticated-orcid":false,"given":"Dinesh","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Advanced Spectroscopy and Imaging, Centre of Biomedical Research (CBMR), SGPGIMS Campus, Lucknow, India."},{"name":"Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, Uttar Pradesh, India."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,3,12]]},"reference":[{"key":"e_1_3_6_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41579-018-0147-4"},{"key":"e_1_3_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmrp.2018.01.001"},{"key":"e_1_3_6_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrneph.2013.100"},{"key":"e_1_3_6_5_2","doi-asserted-by":"publisher","DOI":"10.1177\/08968608221080586"},{"key":"e_1_3_6_6_2","doi-asserted-by":"publisher","DOI":"10.1177\/089686080502500201"},{"key":"e_1_3_6_7_2","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.14631218"},{"key":"e_1_3_6_8_2","doi-asserted-by":"publisher","DOI":"10.3747\/pdi.2010.00049"},{"key":"e_1_3_6_9_2","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.03180906"},{"issue":"3","key":"e_1_3_6_10_2","doi-asserted-by":"crossref","first-page":"415","DOI":"10.4103\/ijmm.IJMM_17_311","article-title":"Survivability and fitness cost of heterogeneous vancomycin-intermediate Staphylococcus aureus","volume":"35","author":"Singh A","year":"2017","unstructured":"Singh A, , Singh S, , Singh J, et al. Survivability and fitness cost of heterogeneous vancomycin-intermediate Staphylococcus aureus. Indian J Med Microbiol, 2017; 35(3):415\u2013416; doi: 10.4103\/ijmm.IJMM_17_311","journal-title":"Indian J Med Microbiol"},{"issue":"1","key":"e_1_3_6_11_2","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1186\/s12879-018-3011-2","article-title":"Morbidity from in-hospital complications is greater than treatment failure in patients with Staphylococcus aureus bacteraemia","volume":"18","author":"Holmes NE","year":"2018","unstructured":"Holmes NE, , Robinson JO, , van Hal SJ, et al.; VANESSA study group, on behalf of the Australasian Society for Infectious Diseases (ASID) Clinical Research Network (CRN). Morbidity from in-hospital complications is greater than treatment failure in patients with Staphylococcus aureus bacteraemia. 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