{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T20:38:19Z","timestamp":1780605499157,"version":"3.54.1"},"reference-count":13,"publisher":"SAGE Publications","issue":"10","license":[{"start":{"date-parts":[[2014,12,1]],"date-time":"2014-12-01T00:00:00Z","timestamp":1417392000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Metabolic Syndrome and Related Disorders"],"published-print":{"date-parts":[[2014,12]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Children with severe cutaneous burn injury show persistent metabolic abnormalities, including inflammation and insulin resistance. Such abnormalities could potentially increase their future risk for developing type 2 diabetes mellitus (T2DM) and cardiovascular disease (CVD). This could be related to changes in body composition and fat distribution.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>We studied body composition, fat distribution, and inflammatory cytokines changes in children with severe burn injury up to 6 months from discharge. Sixty-two boys and 35 girls (burn \u226530% of total body surface area) were included.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      We found a decrease in total body fat and subcutaneous peripheral fat at 6 months (6% and 2%, respectively;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt;0.05 each). An inverse correlation between the decrease in peripheral fat content at 6 months and the extent of burn injury (\n                      <jats:italic toggle=\"yes\">r<\/jats:italic>\n                      =\u2212041,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      =0.02) was also observed. In addition, there was a 12% increase in serum tumor necrosis factor-\u03b1 (TNF-\u03b1) (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      =0.01 vs. discharge) and 9% decrease in serum interleukin-10 (IL-10) (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt;0.0001 vs. discharge) over 6 months after burn.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Severe burn injury in children is associated with changes in body fat content and distribution up to 6 months from hospital discharge. These changes, accompanied by persisting systemic inflammation, could possibly mediate the observed persistence of insulin resistance, predisposing burn patients to the development of T2DM and CVD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/met.2014.0098","type":"journal-article","created":{"date-parts":[[2014,11,17]],"date-time":"2014-11-17T14:52:38Z","timestamp":1416235958000},"page":"523-526","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":12,"title":["Changes in Fat Distribution in Children Following Severe Burn Injury"],"prefix":"10.1177","volume":"12","author":[{"given":"Pavankumar","family":"Patel","sequence":"first","affiliation":[{"name":"The University of Texas Medical Branch"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanaa S.","family":"Sallam","sequence":"additional","affiliation":[{"name":"The University of Texas Medical Branch"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arham","family":"Ali","sequence":"additional","affiliation":[{"name":"The University of Texas Medical Branch"},{"name":"Shriners Hospitals for Children"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manisha","family":"Chandalia","sequence":"additional","affiliation":[{"name":"The University of Texas Medical Branch"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oscar","family":"Suman","sequence":"additional","affiliation":[{"name":"The University of Texas Medical Branch"},{"name":"Shriners Hospitals for Children"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Celeste C.","family":"Finnerty","sequence":"additional","affiliation":[{"name":"The University of Texas Medical Branch"},{"name":"Shriners Hospitals for Children"},{"name":"The University of Texas Medical Branch"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David N.","family":"Herndon","sequence":"additional","affiliation":[{"name":"The University of Texas Medical Branch"},{"name":"Shriners Hospitals for Children"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola","family":"Abate","sequence":"additional","affiliation":[{"name":"The University of Texas Medical Branch"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2014,12,1]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/BCR.0b013e31818481ce"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0b013e3181856241"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0021245"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1177\/0148607199023003160"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.sla.0000217678.78472.d3"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1186\/cc6102"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/ijo.2009.286"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mam.2012.10.001"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/j.1550-8528.1994.tb00076.x"},{"key":"e_1_3_3_11_2","first-page":"137","article-title":"Body composition, visceral fat, leptin, and insulin resistance in Asian Indian men","volume":"84","author":"Banerji M","year":"1999","unstructured":"Banerji M, , Faridi N, , Atluri R, et al. Body composition, visceral fat, leptin, and insulin resistance in Asian Indian men. J Clin Endocrinol Metab, 1999; 84:137\u2013144.","journal-title":"J Clin Endocrinol Metab"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI118083"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2011.11.158"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.107.710509"}],"container-title":["Metabolic Syndrome and Related Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1089\/met.2014.0098","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/met.2014.0098","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/met.2014.0098","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T20:49:09Z","timestamp":1777668549000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1089\/met.2014.0098"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,12]]},"references-count":13,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2014,12]]}},"alternative-id":["10.1089\/met.2014.0098"],"URL":"https:\/\/doi.org\/10.1089\/met.2014.0098","relation":{},"ISSN":["1540-4196","1557-8518"],"issn-type":[{"value":"1540-4196","type":"print"},{"value":"1557-8518","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,12]]}}}