{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T06:59:33Z","timestamp":1782543573778,"version":"3.54.5"},"reference-count":29,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2016,5,1]],"date-time":"2016-05-01T00:00:00Z","timestamp":1462060800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Metabolic Syndrome and Related Disorders"],"published-print":{"date-parts":[[2016,5]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Metabolic syndrome (MetS) and visceral obesity are more prevalent in obstructive sleep apnea syndrome (OSAS). We investigated the association of visceral fat (VF) measures with the components of MetS in OSAS patients with different severity levels, according to World Health Organization (WHO, 1999), National Cholesterol Education Program Adult Treatment Panel III (NCEP-ATP III, 2001), and International Diabetes Federation (IDF, 2005) definitions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and Methods:<\/jats:title>\n                    <jats:p>\n                      Study population was grouped according to polysomnography results as non-OSAS [who had apnea\u2013hypopnea index (AHI) &lt;5,\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      \u2009=\u200951], mild OSAS (5 &lt; AHI &lt;15,\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      \u2009=\u200952), moderate OSAS (15 &lt; AHI &lt;30,\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      \u2009=\u200953), and severe OSAS (AHI &gt;30,\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      \u2009=\u200953). VF ratio was measured by abdominal bioimpedance analysis. Waist-to-hip ratio (WHR), homeostasis model assessment of insulin resistance (HOMA-IR), and lipid profiles were assessed in all subjects.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      The prevelance of MetS in OSAS patients was 30.0%, 35.6%, and 44.4% according to WHO, NCEP-ATP III, and IDF definitions, respectively. MetS was found in 27.5% non-OSAS and 72.8% OSAS according to at least one definition (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u20090.012). Within OSAS group, 27.2% subjects had average, 38.0% had slightly excessive, and 34.8% had an excessive VF ratio. The prevelance of MetS was similar in various VF ratios (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009&gt;\u20090.05). However HOMA-IR increased progressively with VF ratio after adjusting for age, gender, and body mass index (BMI;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u20090.02). AHI increased progressively with BMI (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u20090.02), WHR (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u20090.03), VF ratio (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u20090.01), HOMA-IR (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u20090.02), and MetS (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u20090.016).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Since severity of OSAS, in terms of AHI and insulin resistance, is both associated with VF rather than BMI, VF should be suggested to link OSAS and MetS. The IDF definition is more sensitive in OSAS patients to diagnose MetS, as central obesity and insulin resistance are obligatory components. This would allow clinicians to intervent earlier to adverse metabolic outcomes of OSAS.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/met.2015.0086","type":"journal-article","created":{"date-parts":[[2016,3,22]],"date-time":"2016-03-22T16:58:31Z","timestamp":1458665911000},"page":"217-221","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":27,"title":["Visceral Obesity Mediates the Association Between Metabolic Syndrome and Obstructive Sleep Apnea Syndrome"],"prefix":"10.1177","volume":"14","author":[{"given":"Nujen Colak","family":"Bozkurt","sequence":"first","affiliation":[{"name":"Ankara Diskapi Yildirim Beyazit Teaching and Research Hospital","place":["Turkey"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Selvihan","family":"Beysel","sequence":"additional","affiliation":[{"name":"Ankara Diskapi Yildirim Beyazit Teaching and Research Hospital","place":["Turkey"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Basak","family":"Karbek","sequence":"additional","affiliation":[{"name":"Ankara Diskapi Yildirim Beyazit Teaching and Research Hospital","place":["Turkey"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u0130lknur Ozturk","family":"Unsal","sequence":"additional","affiliation":[{"name":"Ankara Diskapi Yildirim Beyazit Teaching and Research Hospital","place":["Turkey"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evrim","family":"Cakir","sequence":"additional","affiliation":[{"name":"Ankara Diskapi Yildirim Beyazit Teaching and Research Hospital","place":["Turkey"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tuncay","family":"Delibasi","sequence":"additional","affiliation":[{"name":"Hacettepe University","place":["Turkey"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2016,5,1]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.2109080"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.122.3.829"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwh261"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200504-637OC"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2009.04.026"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/oby.20288"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejim.2010.03.006"},{"key":"e_1_3_2_9_2","first-page":"417","article-title":"Prevalence of metabolic syndrome diagnosis in patients with obstructive sleep apnoea syndrome according to adopted definition","volume":"81","author":"Kumor M","year":"2013","unstructured":"Kumor M, , Bielicki P, , Barna\u015b M, et al. 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