{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T08:02:34Z","timestamp":1779696154213,"version":"3.53.1"},"reference-count":45,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2016,3,1]],"date-time":"2016-03-01T00:00:00Z","timestamp":1456790400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Metabolic Syndrome and Related Disorders"],"published-print":{"date-parts":[[2016,3]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>\n                      Variants in the fat mass and obesity-associated (\n                      <jats:italic toggle=\"yes\">FTO<\/jats:italic>\n                      ) gene are associated with obesity and type 2 diabetes mellitus.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim of the study:<\/jats:title>\n                    <jats:p>\n                      This study aims to assess the association of the rs9939609 variant and haplotypes in\n                      <jats:italic toggle=\"yes\">FTO<\/jats:italic>\n                      gene with metabolic syndrome (MetS) components in a Tunisian population sample.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      A total of 685 Tunisian subjects were genotyped for the rs9939609T&gt;A using TaqMan allelic discrimination assay. Two variants rs1421085T&gt;C and rs8057044A&gt;G already genotyped in a previous study were used to test haplotype association of the\n                      <jats:italic toggle=\"yes\">FTO<\/jats:italic>\n                      gene.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Genotype distribution of the variant rs9939609 was different between MetS and controls (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u20090.017). Individuals carrying TA genotypes had a significantly increased risk independently of body mass index or age (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u20090.009). The variant rs9939609 was also associated with impaired fasting glucose (IFG) (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u20090.002). Among the eight haplotypes in the population, the haplotype GCA was significantly associated with a higher risk of developing the MetS, higher systolic blood pressure, and higher levels of fasting glucose and triglycerides (TGs) in the total sample and females, separately. Separate analysis by gender revealed a protective haplotype TGT among women (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u20090.023).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>\n                      <jats:italic toggle=\"yes\">FTO<\/jats:italic>\n                      haplotypes have a strong influence on blood pressures and TG and IFG levels. These findings provide evidence that\n                      <jats:italic toggle=\"yes\">FTO<\/jats:italic>\n                      gene may play a critical role in leading to MetS in Tunisian population.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/met.2015.0090","type":"journal-article","created":{"date-parts":[[2016,1,7]],"date-time":"2016-01-07T17:10:09Z","timestamp":1452186609000},"page":"121-128","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":26,"title":["Association of rs9939609 Polymorphism with Metabolic Parameters and\n                    <i>FTO<\/i>\n                    Risk Haplotype Among Tunisian Metabolic Syndrome"],"prefix":"10.1177","volume":"14","author":[{"given":"Sahar","family":"Elouej","sequence":"first","affiliation":[{"name":"Institut Pasteur de Tunis","place":["Tunisia"]},{"name":"Universit\u00e9 de Tunis El 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