{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T19:39:29Z","timestamp":1777923569149,"version":"3.51.4"},"reference-count":33,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2020,9,25]],"date-time":"2020-09-25T00:00:00Z","timestamp":1600992000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Metabolic Syndrome and Related Disorders"],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Thyroid nodule is the most common disorder of thyroid. Metabolic syndrome was regarded as an important factor for the prevalence of thyroid nodule. Homocysteine has been shown to be related to metabolic syndrome, inflammation, and several common cancers. In this study, we aimed to investigate the relationship between serum homocysteine and the prevalence of thyroid nodule.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>This was a cross-sectional study that included 2040 adults in a health checkup population in Beijing Chao-yang hospital. Thyroid ultrasound data, together with anthropometric characteristics, metabolic parameters, and serum homocysteine, were recorded respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Hyperhomocysteinemia (defined as serum homocysteine \u226515\u2009\u03bcmol\/L) was detected in 452 participants (21.91%). Thyroid nodule prevalence was significantly higher in hyperhomocysteinemia participants than in normal homocysteine participants (52.57% vs. 45.16%,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u20090.006). Logistic regression analysis revealed that age [odds ratio (OR) 1.054;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009&lt;\u20090.001], female gender (OR 2.242;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009&lt;\u20090.001), body mass index (OR 1.050;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009&lt;\u20090.001), and serum homocysteine level (OR 1.022;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u20090.001) were the independent risk factors for thyroid nodule.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Subjects with hyperhomocysteinemia have significantly higher thyroid nodule prevalence. Homocysteine is an independent risk factor for thyroid nodule. It implies that individuals with hyperhomocysteinemia have higher susceptibility to thyroid nodule.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/met.2020.0057","type":"journal-article","created":{"date-parts":[[2020,6,29]],"date-time":"2020-06-29T12:57:47Z","timestamp":1593435467000},"page":"368-372","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["The Association Between Hyperhomocysteinemia and Thyroid Nodule Prevalence in an Adult Population"],"prefix":"10.1177","volume":"18","author":[{"given":"Qingrong","family":"Pan","sequence":"first","affiliation":[{"name":"Department of Endocrinology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Wang","sequence":"additional","affiliation":[{"name":"Physical Examination Center, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2020,9,25]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/965212"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2015-008452"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph13040442"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.112.054353"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2006.0337"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2362.2009.02162.x"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12020-017-1285-6"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-09-0410"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.3904\/kjim.2015.273"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/106.6.709"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.dsx.2016.08.026"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.3390\/nu11071614"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.3390\/biom10030393"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0009-8981(02)00174-2"},{"key":"e_1_3_3_16_2","article-title":"Elevated homocysteine level and folate deficiency associated with increased overall risk of carcinogenesis: Meta-analysis of 83 case-control studies involving 35,758 individuals","volume":"10","author":"Zhang D","year":"2015","unstructured":"Zhang D, , Wen X, , Wu W, et al. Elevated homocysteine level and folate deficiency associated with increased overall risk of carcinogenesis: Meta-analysis of 83 case-control studies involving 35,758 individuals. 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