{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T17:44:29Z","timestamp":1789839869006,"version":"4.0.1"},"reference-count":15,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2021,5,27]],"date-time":"2021-05-27T00:00:00Z","timestamp":1622073600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Metabolic Syndrome and Related Disorders"],"published-print":{"date-parts":[[2021,6]]},"abstract":"\n Background:<\/jats:title>\n This study aims to evaluate metabolic and oxidative stress markers in a postmenopausal rat model of polycystic ovary syndrome (PCOS).<\/jats:p>\n <\/jats:sec>\n \n Methods:<\/jats:title>\n \n Wistar rats were divided in four groups: control ovariectomized (OVX;\n n<\/jats:italic>\n \u2009=\u20099), control SHAM (\n n<\/jats:italic>\n \u2009=\u20099), androgenized OVX (\n n<\/jats:italic>\n \u2009=\u200910), and androgenized SHAM (\n n<\/jats:italic>\n \u2009=\u200910). Female rats were androgenized during the neonatal period and compared with controls. Surgery (ovariectomy or SHAM procedure) was performed at day 100 and euthanasia at day 180 of life. Bodyweight, lipids, glucose, triglyceride glucose (TyG) index, and oxidative stress markers (total oxidant status [TOS], total antioxidant capacity, nitric oxide, ferric-reducing ability of plasma [FRAP], and advanced oxidation protein product) were addressed.\n <\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n Androgenized SHAM rats exhibited a higher total, low-density lipoprotein cholesterol, triglycerides, TyG index (an insulin resistance marker), and increased TOS, FRAP, and albumin in comparison with control SHAM rats. These abnormalities disappeared after ovariectomy despite the fact that ovariectomized androgenized rats became heavier than the other three groups.<\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n Ovariectomy improved metabolic and oxidative stress markers in a rat model of PCOS.<\/jats:p>\n <\/jats:sec>","DOI":"10.1089\/met.2020.0077","type":"journal-article","created":{"date-parts":[[2021,3,2]],"date-time":"2021-03-02T11:37:38Z","timestamp":1614685058000},"page":"312-316","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["Ovariectomy Improves Metabolic and Oxidative Stress Marker Disruption in Androgenized Rats: Possible Approach to Postmenopausal Polycystic Ovary Syndrome"],"prefix":"10.1177","volume":"19","author":[{"given":"Lady Katerine","family":"Serrano Mujica","sequence":"first","affiliation":[{"name":"Laboratory of Biotechnology and Animal Reproduction\u2014BioRep, Federal University of Santa Maria (UFSM), Santa Maria, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolina S.","family":"Stein","sequence":"additional","affiliation":[{"name":"Laboratory of Clinical Biochemistry, Department of Clinical and Toxicological Analysis, Federal University of Santa Maria (UFSM), Santa Maria, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ligia Gomes","family":"Miyazato","sequence":"additional","affiliation":[{"name":"Animal Care Facility, Federal University of Santa Maria (UFSM), Santa Maria, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernanda","family":"Valente","sequence":"additional","affiliation":[{"name":"Animal Care Facility, Federal University of Santa Maria (UFSM), Santa Maria, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa Orlandin","family":"Premaor","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine, Federal University of Santa Maria (UFSM), Santa Maria, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfredo Quites","family":"Antoniazzi","sequence":"additional","affiliation":[{"name":"Laboratory of Biotechnology and Animal Reproduction\u2014BioRep, Federal University of Santa Maria (UFSM), Santa Maria, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael Noal","family":"Moresco","sequence":"additional","affiliation":[{"name":"Laboratory of Clinical Biochemistry, Department of Clinical and Toxicological Analysis, Federal University of Santa Maria (UFSM), Santa Maria, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio Vasconcellos","family":"Comim","sequence":"additional","affiliation":[{"name":"Laboratory of Biotechnology and Animal Reproduction\u2014BioRep, Federal University of Santa Maria (UFSM), Santa Maria, Brazil."},{"name":"Department of Clinical Medicine, Federal University of Santa Maria (UFSM), Santa Maria, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2021,5,27]]},"reference":[{"key":"e_1_3_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2018.05.004"},{"key":"e_1_3_6_3_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2011-1677"},{"key":"e_1_3_6_4_2","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.9553"},{"key":"e_1_3_6_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/cen.13171"},{"key":"e_1_3_6_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/cen.13477"},{"key":"e_1_3_6_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2018.08.021"},{"key":"e_1_3_6_8_2","doi-asserted-by":"publisher","DOI":"10.4103\/ijpvm.IJPVM_576_17"},{"key":"e_1_3_6_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.steroids.2013.05.004"},{"key":"e_1_3_6_10_2","doi-asserted-by":"publisher","DOI":"10.2147\/JIR.S160264"},{"key":"e_1_3_6_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2016.12.015"},{"key":"e_1_3_6_12_2","doi-asserted-by":"publisher","DOI":"10.1210\/en.2019-00450"},{"key":"e_1_3_6_13_2","doi-asserted-by":"publisher","DOI":"10.1210\/en.2015-1617"},{"key":"e_1_3_6_14_2","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7827-3-44"},{"key":"e_1_3_6_15_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12958-019-0509-4"},{"key":"e_1_3_6_16_2","doi-asserted-by":"publisher","DOI":"10.1530\/EC-18-0129"}],"container-title":["Metabolic 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