{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T19:24:29Z","timestamp":1793647469994,"version":"4.5.1"},"reference-count":25,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Metabolic Syndrome and Related Disorders"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Pentraxin 3 (PTX3) is an acute-phase protein, which resembles C-reactive protein in both structure and function, and belongs to the same family. PTX3 is associated with cardiovascular diseases, obesity, and metabolic syndrome (MetS). This study evaluated the relationship between serum PTX3 levels, prediabetes, newly diagnosed type 2 diabetes mellitus (T2DM), and other biochemical and clinical parameters in obese patients with nonalcoholic fatty liver disease (NAFLD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>A total of 77 obese patients with NAFLD were included. Forty-seven of them were with normal glucose levels and 30 were with glycemic disorders, including prediabetes and newly diagnosed T2DM. Serum PTX3 was measured using ELISA method.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Higher PTX3 serum levels were found in patients with prediabetes and T2DM compared with those with normal blood glucose (2321.29\u2009\u00b1\u2009926.63 vs. 1877.03\u2009\u00b1\u2009895.45\u2009pg\/mL,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u20090.028). There were significant correlations between PTX3 and alanine aminotransferase (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u20090.018), gamma-glutamyl transferase (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u20090.005), and neuropathy disability score (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009&lt;\u20090.05). The presence of hypertension, dyslipidemia, insulin resistance, and MetS, as well as the number of components of the MetS did not affect PTX3 levels.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>PTX3 serum levels were higher in an obese subject with NAFLD with prediabetes and T2DM.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/met.2021.0086","type":"journal-article","created":{"date-parts":[[2021,11,24]],"date-time":"2021-11-24T15:44:31Z","timestamp":1637768671000},"page":"132-136","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":15,"title":["Increased Serum Pentraxin 3 Is Associated with Prediabetes and Type 2 Diabetes in Obese Patients with Nonalcoholic Fatty Liver Disease"],"prefix":"10.1177","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9712-2298","authenticated-orcid":false,"given":"Vera","family":"Karamfilova","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Clinic of Endocrinology and Metabolic Disease, University Hospital \u201cAlexandrovska,\u201d Medical University Sofia, Sofia, Bulgaria."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yavor","family":"Assyov","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Clinic of Endocrinology and Metabolic Disease, University Hospital \u201cAlexandrovska,\u201d Medical University Sofia, Sofia, Bulgaria."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8819-3032","authenticated-orcid":false,"given":"Iveta","family":"Nedeva","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Clinic of Endocrinology and Metabolic Disease, University Hospital \u201cAlexandrovska,\u201d Medical University Sofia, Sofia, Bulgaria."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antoaneta","family":"Gateva","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Clinic of Endocrinology and Metabolic Disease, University Hospital \u201cAlexandrovska,\u201d Medical University Sofia, Sofia, Bulgaria."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irena","family":"Ivanova","sequence":"additional","affiliation":[{"name":"Clinical Laboratory Department, University Hospital \u201cSt. Ivan Rilski,\u201d Medical University of Sofia, Sofia, Bulgaria."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikolay","family":"Cherkezov","sequence":"additional","affiliation":[{"name":"Emergency Department, University Hospital \u201cSt. Anna,\u201d Medical University of Sofia, Sofia, Bulgaria."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ludmila","family":"Mateva","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Clinic of Gastroenterology, University Hospital \u201cSt. Ivan Rilski,\u201d Medical University Sofia, Sofia, Bulgaria."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zdravko","family":"Kamenov","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Clinic of Endocrinology and Metabolic Disease, University Hospital \u201cAlexandrovska,\u201d Medical University Sofia, Sofia, Bulgaria."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2022,3,15]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.29367"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21165888"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2020.03.039"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.31420"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00592-018-1266-0"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-230X-10-56"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2010-2190"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1159\/000343904"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/8968573"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2007.08.013"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1620\/tjem.239.73"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/1417962"},{"key":"e_1_3_3_14_2","article-title":"Proportional correlates of cystatin-C with pentraxin-3, visceral adiposity index and atherogenicity index of plasma but not blood indices in metabolic syndrome patients with and without prediabetes","volume":"36","author":"Al-Batsh M","year":"2018","unstructured":"Al-Batsh M, , Albsoul-Younes A, , Kasabri V, et al. Proportional correlates of cystatin-C with pentraxin-3, visceral adiposity index and atherogenicity index of plasma but not blood indices in metabolic syndrome patients with and without prediabetes. Horm Mol Biol Clin Investig, 2018; 36:20180058.","journal-title":"Horm Mol Biol Clin Investig"},{"key":"e_1_3_3_15_2","article-title":"The performance of enhanced liver fibrosis (ELF) test for the staging of liver fibrosis: A meta-analysis","volume":"9","author":"Xie O","year":"2014","unstructured":"Xie O, , Zhou X, , Huang P, et al. The performance of enhanced liver fibrosis (ELF) test for the staging of liver fibrosis: A meta-analysis. PLoS One, 2014; 9:e92772.","journal-title":"PLoS One"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.2337\/dc09-1825"},{"key":"e_1_3_3_17_2","unstructured":"World Health Organization & International Diabetes Federation. Definition and Diagnosis of Diabetes Mellitus and Intermediate Hyperglycaemia. Geneva: Report of a WHO\/IDF Consultation 2006."},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.109.192644"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.5582\/ddt.2015.01207"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1111\/jdi.12575"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1464-5491.2002.00698.x"},{"key":"e_1_3_3_22_2","first-page":"1583","article-title":"Highsensitive CRP and pentraxine 3 as noninvasive biomarkers of nonalcoholic fatty liver disease","volume":"8","author":"Maleki I","year":"2014","unstructured":"Maleki I, , Rastgar A, , Hosseinietal V. Highsensitive CRP and pentraxine 3 as noninvasive biomarkers of nonalcoholic fatty liver disease. Eur Rev Med Pharm Sci, 2014; 8:1583\u20131590.","journal-title":"Eur Rev Med Pharm Sci"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000012282.39306.64"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2009.10.033"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2012.268"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10238-009-0039-z"}],"container-title":["Metabolic Syndrome and Related Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1089\/met.2021.0086","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/met.2021.0086","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/met.2021.0086","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T20:54:29Z","timestamp":1777668869000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1089\/met.2021.0086"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3]]},"references-count":25,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2022,3]]}},"alternative-id":["10.1089\/met.2021.0086"],"URL":"https:\/\/doi.org\/10.1089\/met.2021.0086","relation":{},"ISSN":["1540-4196","1557-8518"],"issn-type":[{"value":"1540-4196","type":"print"},{"value":"1557-8518","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,3]]}}}