{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,20]],"date-time":"2026-06-20T18:51:46Z","timestamp":1781981506629,"version":"3.54.5"},"reference-count":65,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Metabolic Syndrome and Related Disorders"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:p>It is well established that diets containing an increased omega-6 polyunsaturated fatty acid (n-6 PUFA) to omega-3 polyunsaturated fatty acid (n-3 PUFA) ratios are linked to inflammation and chronic diseases such as nonalcoholic fatty liver disease (NAFLD). However, the influence of an elevated n-6 PUFA:n-3 PUFA ratio in the tissues requires clarification. Herein, we identified primary experimental and clinical studies where it is possible to compare the performance of the myristic acid (Myr):docosahexaenoic acid (DHA) and n-6 PUFA:n-3 PUFA ratios in the liver and\/or serum as potential NAFLD biomarkers. Articles were included if quantitative values of n-6 PUFA, n-3 PUFA, Myr, DHA, and information about liver inflammation or liver disease progression parameters were provided. Overall, most experimental (91.6%) and clinical studies (87.5%) reported higher Myr:DHA ratios associated with inflammation and\/or NAFLD progression than the n-6 PUFA:n-3 PUFA ratio. We conclude that the Myr:DHA ratio represents a better biomarker of NAFLD than the n-6 PUFA:n-3 PUFA ratio. Future studies are necessary for verifying this observation.<\/jats:p>","DOI":"10.1089\/met.2021.0107","type":"journal-article","created":{"date-parts":[[2021,11,23]],"date-time":"2021-11-23T16:56:06Z","timestamp":1637686566000},"page":"69-78","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["The Myristic Acid:Docosahexaenoic Acid Ratio Versus the n-6 Polyunsaturated Fatty Acid:n-3 Polyunsaturated Fatty Acid Ratio as Nonalcoholic Fatty Liver Disease Biomarkers"],"prefix":"10.1177","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4728-8518","authenticated-orcid":false,"given":"Marina","family":"Masetto Antunes","sequence":"first","affiliation":[{"name":"Post-Graduation Program in Pharmaceutical Sciences, State University of Maring\u00e1, Maring\u00e1, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guilherme","family":"Godoy","sequence":"additional","affiliation":[{"name":"Post-Graduation Program in Pharmaceutical Sciences, State University of Maring\u00e1, Maring\u00e1, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Curi","sequence":"additional","affiliation":[{"name":"Interdisciplinary Post-Graduate Program in Health Sciences, Cruzeiro do Sul University, S\u00e3o Paulo, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jesu\u00ed","family":"Verg\u00edlio Visentainer","sequence":"additional","affiliation":[{"name":"Department of Chemistry, State University of Maring\u00e1, Maring\u00e1, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8563-7913","authenticated-orcid":false,"given":"Roberto","family":"Barbosa Bazotte","sequence":"additional","affiliation":[{"name":"Post-Graduation Program in Pharmaceutical Sciences, State University of Maring\u00e1, Maring\u00e1, Brazil."},{"name":"Department of Pharmacology and Therapeutics, State University of Maring\u00e1, Maring\u00e1, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2022,3,15]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/86.2.285"},{"key":"e_1_3_3_3_2","first-page":"2263","article-title":"Nonalcoholic fatty liver disease: A systematic review","volume":"313","author":"Rinella ME","year":"2015","unstructured":"Rinella ME. 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