{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T19:41:39Z","timestamp":1777923699656,"version":"3.51.4"},"reference-count":45,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Metabolic Syndrome and Related Disorders"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Pediatric studies have shown associations between hepatic steatosis and total body fat, visceral fat, and lean mass. However, these associations have not been assessed simultaneously, leaving their relative importance unknown.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To evaluate associations between hepatic steatosis and total-body adiposity, visceral adiposity, and lean mass in children.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method:<\/jats:title>\n                    <jats:p>In children at risk for fatty liver, hepatic steatosis, adipose, and lean mass were estimated with magnetic resonance imaging and dual-energy X-ray absorptiometry.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Two hundred twenty-seven children with mean age 12.1 years had mean percent body fat of 38.9% and mean liver fat of 8.4%. Liver fat was positively associated with total-body adiposity, visceral adiposity, and lean mass (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009&lt;\u20090.001), and negatively associated with lean mass percentage (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009&lt;\u20090.001). After weight adjustment, liver fat was only positively associated with measures of central adiposity (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009&lt;\u20090.001). Visceral adiposity also had the strongest association with liver fat (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009&lt;\u20090.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>In children, hepatic steatosis is more strongly associated with visceral adiposity than total adiposity, and the association of lean mass is not independent of weight or fat mass. These relationships may help guide the choice of future interventions to target hepatic steatosis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/met.2023.0002","type":"journal-article","created":{"date-parts":[[2023,4,21]],"date-time":"2023-04-21T14:23:05Z","timestamp":1682086985000},"page":"222-230","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["Association of Hepatic Steatosis with Adipose and Muscle Mass and Distribution in Children"],"prefix":"10.1177","volume":"21","author":[{"given":"Ghattas J.","family":"Malki","sequence":"first","affiliation":[{"name":"Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, University of California San Diego School of Medicine, La Jolla, California, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nidhi P.","family":"Goyal","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, University of California San Diego School of Medicine, La Jolla, California, USA."},{"name":"Department of Gastroenterology, Rady Children's Hospital, San Diego, California, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricia","family":"Ugalde-Nicalo","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Rady Children's Hospital, San Diego, California, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lauren F.","family":"Chun","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, University of California San Diego School of Medicine, La Jolla, California, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jasen","family":"Zhang","sequence":"additional","affiliation":[{"name":"Division of Biostatistics and Bioinformatics, University of California San Diego Herbert Wertheim School of Public Health and Human Longevity Science, San Diego, California, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ziyi","family":"Ding","sequence":"additional","affiliation":[{"name":"Division of Biostatistics and Bioinformatics, University of California San Diego Herbert Wertheim School of Public Health and Human Longevity Science, San Diego, California, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yingjia","family":"Wei","sequence":"additional","affiliation":[{"name":"Division of Biostatistics and Bioinformatics, University of California San Diego Herbert Wertheim School of Public Health and Human Longevity Science, San Diego, California, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0311-2158","authenticated-orcid":false,"given":"Cynthia","family":"Knott","sequence":"additional","affiliation":[{"name":"Altman Clinical and Translational Research Institute, School of Medicine, University of California San Diego School of Medicine, La Jolla, California, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Danielle","family":"Batakis","sequence":"additional","affiliation":[{"name":"Liver Imaging Group, Department of Radiology, University of California San Diego School of Medicine, La Jolla, California, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Walter","family":"Henderson","sequence":"additional","affiliation":[{"name":"Liver Imaging Group, Department of Radiology, University of California San Diego School of Medicine, La Jolla, California, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claude B.","family":"Sirlin","sequence":"additional","affiliation":[{"name":"Liver Imaging Group, Department of Radiology, University of California San Diego School of Medicine, La Jolla, California, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael 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