{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T14:57:42Z","timestamp":1781103462990,"version":"3.54.1"},"reference-count":43,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Metabolic Syndrome and Related Disorders"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Previous evidence has demonstrated that elevated low-density lipoprotein cholesterol (LDL-C) was associated with atherosclerosis. However, there is scarce population-based evidence for the role of remnant cholesterol (remnant-C) in arterial stiffness, an imaging marker for subclinical atherosclerosis. Herein, we aimed to evaluate the correlation of remnant-C with arterial stiffness beyond LDL-C in a check-up population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>The study included consecutive subjects who visited the Murakami Memorial Hospital for health check-ups between 2004 and 2012. The calculation of remnant-C occurred as total cholesterol minus high-density lipoprotein cholesterol (HDL-C) minus LDL-C. The brachial-ankle pulse wave velocity (baPWV) &gt;1400\u2009cm\/sec was defined as arterial stiffness or baPWV abnormality. The independent correlation of remnant-C level to arterial stiffness was evaluated using adjusted regression models.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      A total of 909 participants were included (mean age 51.1\u2009\u00b1\u20099.6 years, male sex 64.9%). In multivariate linear regression analyses, remnant-C remained an independent predictor of the baPWV predictor [\u03b2: 94.76, 95% confidence interval (CI) 42.19\u2013147.33,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009&lt;\u20090.001] after adjusting for confounders. After multivariable adjustment, including LDL-C, the highest remnant-C quartile odd ratio (OR) (95% CI) was 2.79 (1.27\u20136.09) for baPWV abnormality compared to the lowest quartile. Furthermore, each 10-mg\/dL increase in remnant-C correlated with a 28% increased risk for baPWV abnormality (OR: 1.28, 95% CI: 1.04\u20131.57). Moreover, the correlation between remnant-C and baPWV abnormality was still significant in the participant subgroup with optimal levels of LDL-C.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Our findings demonstrated that remnant-C levels correlated to arterial stiffness with the dependence of LDL-C and other cardiovascular risk factors in a check-up population.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/met.2023.0101","type":"journal-article","created":{"date-parts":[[2023,10,30]],"date-time":"2023-10-30T11:40:42Z","timestamp":1698666042000},"page":"526-534","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["The Role of Remnant Cholesterol Beyond Low-Density Lipoprotein Cholesterol in Arterial Stiffness: A Cross-Sectional Study"],"prefix":"10.1177","volume":"21","author":[{"given":"Peng","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Neurology, Clinical Medical College, Jining Medical University, Jining, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinfeng","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Neurology, the Affiliated Hospital of Jining Medical University, Jining, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daojing","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Neurology, the Affiliated Hospital of Jining Medical University, Jining, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiuhua","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Neurology, the Affiliated Hospital of Jining Medical University, Jining, 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