{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T14:49:13Z","timestamp":1787496553388,"version":"build-2736575974"},"reference-count":17,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Metabolic Syndrome and Related Disorders"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:p>\n                    The metabolic profile during prolactinoma may be subject to significant changes. We aimed to describe the different metabolic aspects in patients monitored for prolactinoma and to study the correlations between the size of the prolactinoma and the metabolic parameters. We conducted a retrospective, descriptive, and analytical study of 77 cases of prolactinomas collected and monitored at the endocrinology and diabetology department of the Hedi Chaker Hospital in Sfax between 2000 and 2017. Our patients were divided into three groups according to the size of their prolactinomas. Statistical correlations were sought between tumor size and clinical and biological parameters. The mean age of our patients was 38.3\u2009\u00b1\u200914.2 years. They were divided into 51 women (66.2%) and 26 men (33.7%). Pituitary tumor syndrome was the most common circumstance of discovery in our population (62.3%). The clinical examination revealed an average waist circumference of 95.71\u2009cm. Android fat distribution was observed in 25 women (49%) and 12 men (46.1%). A statistically significant positive correlation was objectified between waist circumference and tumor size (\n                    <jats:italic toggle=\"yes\">r<\/jats:italic>\n                    \u2009=\u20090.29 and\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    \u2009=\u20090.019). The average body mass index was 28.08\u2009kg\/m\n                    <jats:sup>2<\/jats:sup>\n                    . Obesity was noted in 56 cases (72.7%). Glucose tolerance disorders and hypertriglyceridemia were also more evident each time prolactinoma size increased in contrast to the level of high-density lipoprotein cholesterol which decreased with adenoma size. Our study highlighted the metabolic and hormonal repercussions of prolactinomas. Metabolic syndrome was more common in patients with larger prolactinoma. These results should guide the initial assessment and therapeutic management of prolactin adenomas.\n                  <\/jats:p>","DOI":"10.1089\/met.2023.0174","type":"journal-article","created":{"date-parts":[[2024,1,17]],"date-time":"2024-01-17T17:00:57Z","timestamp":1705510857000},"page":"85-89","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Metabolic Disorders During Prolactinomas"],"prefix":"10.1177","volume":"22","author":[{"given":"Mouna","family":"Elleuch","sequence":"first","affiliation":[{"name":"Department of Endocrinolgy Diabetology, Hedi Chaker Hospital, University of Sfax, Sfax, Tunisia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1761-3703","authenticated-orcid":false,"given":"Molka","family":"Ben Bnina","sequence":"additional","affiliation":[{"name":"Department of Endocrinolgy Diabetology, Hedi Chaker Hospital, University of Sfax, Sfax, Tunisia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatma","family":"Loukil","sequence":"additional","affiliation":[{"name":"Department of Endocrinolgy Diabetology, Hedi Chaker Hospital, University of Sfax, Sfax, Tunisia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faten","family":"Hadj Kacem","sequence":"additional","affiliation":[{"name":"Department of Endocrinolgy Diabetology, Hedi Chaker Hospital, University of Sfax, Sfax, Tunisia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khouloud","family":"Boujelben","sequence":"additional","affiliation":[{"name":"Department of Endocrinolgy Diabetology, Hedi Chaker Hospital, University of Sfax, Sfax, Tunisia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mouna","family":"Mnif","sequence":"additional","affiliation":[{"name":"Department of Endocrinolgy Diabetology, Hedi Chaker Hospital, University of Sfax, Sfax, Tunisia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatma","family":"Mnif","sequence":"additional","affiliation":[{"name":"Department of Endocrinolgy Diabetology, Hedi Chaker Hospital, University of Sfax, Sfax, Tunisia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadia","family":"Charfi","sequence":"additional","affiliation":[{"name":"Department of Endocrinolgy Diabetology, Hedi Chaker Hospital, University of Sfax, Sfax, Tunisia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nabila","family":"Rekik","sequence":"additional","affiliation":[{"name":"Department of Endocrinolgy Diabetology, Hedi Chaker Hospital, University of Sfax, Sfax, Tunisia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dhouha","family":"Ben Salah","sequence":"additional","affiliation":[{"name":"Department of Endocrinolgy Diabetology, Hedi Chaker Hospital, University of Sfax, Sfax, Tunisia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed","family":"Abid","sequence":"additional","affiliation":[{"name":"Department of Endocrinolgy Diabetology, Hedi Chaker Hospital, University of Sfax, Sfax, Tunisia."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,3,14]]},"reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.1590\/0004-2730000002961"},{"key":"e_1_3_5_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/cen.13064"},{"key":"e_1_3_5_4_2","doi-asserted-by":"crossref","unstructured":"Bonneville JF. Magnetic Resonance Imaging of Pituitary Tumors. In: Frontiers of Hormone Research. (Buchfelder M Guaraldi F. \u00e9ds.) Basel Switzerland: Karger AG; 2016; pp. 97\u2013120.","DOI":"10.1159\/000442327"},{"key":"e_1_3_5_5_2","doi-asserted-by":"publisher","DOI":"10.5455\/medarh.2013.67.22-24"},{"issue":"3","key":"e_1_3_5_6_2","first-page":"269","article-title":"Demographic characteristics, presentations and treatment outcome of patients with prolactinoma","volume":"26","author":"Malik S","year":"2014","unstructured":"Malik S, , Hussain SZ, , Basit R, et al. Demographic characteristics, presentations and treatment outcome of patients with prolactinoma. J Ayub Med Coll Abbottabad, 2014; 26(3):269\u2013274.","journal-title":"J Ayub Med Coll Abbottabad"},{"key":"e_1_3_5_7_2","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-15-0189"},{"key":"e_1_3_5_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jocn.2014.07.020"},{"key":"e_1_3_5_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11102-010-0277-9"},{"key":"e_1_3_5_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/oby.2010.150"},{"key":"e_1_3_5_11_2","doi-asserted-by":"publisher","DOI":"10.1159\/000357810"},{"issue":"9","key":"e_1_3_5_12_2","first-page":"10","article-title":"Role of hypothalamo-hypophyseal-adrenal axis in the pathogenesis of arterial hypertension in patients with prolactinoma of the anterior lobe of the hypophysis","volume":"72","author":"Mychka VB","year":"2000","unstructured":"Mychka VB, , Chazova IE, , Dmitriev VV, et al. Role of hypothalamo-hypophyseal-adrenal axis in the pathogenesis of arterial hypertension in patients with prolactinoma of the anterior lobe of the hypophysis. Ter Arkh, 2000; 72(9):10\u201313.","journal-title":"Ter Arkh"},{"key":"e_1_3_5_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12020-018-1703-4"},{"key":"e_1_3_5_14_2","doi-asserted-by":"publisher","DOI":"10.1590\/2359-3997000000195"},{"key":"e_1_3_5_15_2","unstructured":"Chambeh W. Prolactinomas Diagnostic Modalities Monitoring and Support: About 37 cases. University of Medicine of Sousse: Sousse; 2009."},{"key":"e_1_3_5_16_2","doi-asserted-by":"publisher","DOI":"10.1210\/edrv.19.3.0334"},{"key":"e_1_3_5_17_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40618-016-0483-z"},{"key":"e_1_3_5_18_2","doi-asserted-by":"publisher","DOI":"10.1159\/000489264"}],"container-title":["Metabolic Syndrome and Related Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1089\/met.2023.0174","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/met.2023.0174","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/met.2023.0174","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T20:56:18Z","timestamp":1777668978000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1089\/met.2023.0174"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3]]},"references-count":17,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2024,3]]}},"alternative-id":["10.1089\/met.2023.0174"],"URL":"https:\/\/doi.org\/10.1089\/met.2023.0174","relation":{},"ISSN":["1540-4196","1557-8518"],"issn-type":[{"value":"1540-4196","type":"print"},{"value":"1557-8518","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,3]]}}}