{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T06:50:22Z","timestamp":1778741422277,"version":"3.51.4"},"reference-count":14,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2012,9,10]],"date-time":"2012-09-10T00:00:00Z","timestamp":1347235200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2012,9,10]],"date-time":"2012-09-10T00:00:00Z","timestamp":1347235200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Nucleic Acid Therapeutics"],"published-print":{"date-parts":[[2012,10,1]]},"abstract":"<jats:p>\n                    We previously reported that an octaarginine- and pH-sensitive fusogenic peptide-modified multifunctional envelope-type nano device (R8-GALA-MEND) produces a high level of gene expression in the liver. In this study, we report on an examination of whether this gene delivery system exerts potent hepatoprotective effects against lipopolysaccharide\/D-galactosamine (LPS\/D-GalN)-induced acute liver injury.\n                    <jats:italic toggle=\"yes\">In vivo<\/jats:italic>\n                    -jetPEI\n                    <jats:sup>\u2122<\/jats:sup>\n                    -Gal, a commercially available\n                    <jats:italic toggle=\"yes\">in vivo<\/jats:italic>\n                    transfection reagent, was used as a reference. The systemic administration of the R8-GALA-MEND or\n                    <jats:italic toggle=\"yes\">in vivo<\/jats:italic>\n                    -jetPEI\n                    <jats:sup>\u2122<\/jats:sup>\n                    -Gal showed that the latter was more toxic than the R8-GALA-MEND, indicating that R8-GALA-MEND is a safer system than\n                    <jats:italic toggle=\"yes\">in vivo<\/jats:italic>\n                    -jetPEI\n                    <jats:sup>\u2122<\/jats:sup>\n                    -Gal. Pretreatment with R8-GALA-MEND or\n                    <jats:italic toggle=\"yes\">in vivo<\/jats:italic>\n                    -jetPEI\n                    <jats:sup>\u2122<\/jats:sup>\n                    -Gal loaded with hepatocyte growth factor (HGF) pDNA inhibited serum GPT and GOT levels from becoming elevated. However, the survival rate of the mice was significantly enhanced in the case of R8-GALA-MEND, but not for the\n                    <jats:italic toggle=\"yes\">in vivo<\/jats:italic>\n                    -jetPEI\n                    <jats:sup>\u2122<\/jats:sup>\n                    -Gal treatment. These results demonstrate that R8-GALA-MEND has the potential for use in the pretreatment of an acute liver injury.\n                  <\/jats:p>","DOI":"10.1089\/nat.2012.0352","type":"journal-article","created":{"date-parts":[[2018,8,9]],"date-time":"2018-08-09T22:53:59Z","timestamp":1533855239000},"page":"360-363","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":25,"title":["Pretreatment of Hepatocyte Growth Factor Gene Transfer Mediated by Octaarginine Peptide-Modified Nanoparticles Ameliorates LPS\/D-Galactosamine-Induced Hepatitis"],"prefix":"10.1177","volume":"22","author":[{"given":"Yasuhiro","family":"Hayashi","sequence":"first","affiliation":[{"name":"Hokkaido University","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryoichi","family":"Mizuno","sequence":"additional","affiliation":[{"name":"Hokkaido University","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Khalil A.","family":"Ikramy","sequence":"additional","affiliation":[{"name":"Assiut University","place":["Egypt"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hidetaka","family":"Akita","sequence":"additional","affiliation":[{"name":"Hokkaido University","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideyoshi","family":"Harashima","sequence":"additional","affiliation":[{"name":"Hokkaido University","place":["Japan"]},{"name":"Hokkaido University","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2012,9,10]]},"reference":[{"key":"e_1_3_3_2_1","doi-asserted-by":"publisher","DOI":"10.1021\/mp200189s"},{"key":"e_1_3_3_3_1","doi-asserted-by":"publisher","DOI":"10.1517\/17425240903241796"},{"key":"e_1_3_3_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0270-9139(93)90237-H"},{"key":"e_1_3_3_5_1","first-page":"240","article-title":"Fulminant hepatic failure: summary of a workshop","volume":"21","author":"HOOFNAGLE J. H.","year":"1995","unstructured":"HOOFNAGLE J. H., , CARITHERS R. L.Jr., , SHAPIRO C., , ASCHER H. 1995. Fulminant hepatic failure: summary of a workshop. Hepatology, 21:240\u2013252.","journal-title":"Hepatology"},{"key":"e_1_3_3_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840160520"},{"key":"e_1_3_3_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2011.08.012"},{"key":"e_1_3_3_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2004.04.024"},{"key":"e_1_3_3_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.510300102"},{"key":"e_1_3_3_10_1","first-page":"G642","article-title":"Importance of the liver in plasma clearance of hepatocyte growth factors in rats","volume":"263","author":"LIU K. X.","year":"1992","unstructured":"LIU K. X., , KATO Y., , NARUKAWA M., , KIM D. C., , HANANO M., , HIGUCHI O., , NAKAMURA T., , SUGIYAMA Y. 1992. Importance of the liver in plasma clearance of hepatocyte growth factors in rats. Am. J. Physiol., 263:G642\u2013G649.","journal-title":"Am. J. Physiol."},{"key":"e_1_3_3_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.510260111"},{"key":"e_1_3_3_12_1","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.2000.3793"},{"key":"e_1_3_3_13_1","doi-asserted-by":"publisher","DOI":"10.1210\/endo.131.6.1446596"},{"key":"e_1_3_3_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2011.04.047"},{"key":"e_1_3_3_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.jbchem.a123900"}],"container-title":["Nucleic Acid Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1089\/nat.2012.0352","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/nat.2012.0352","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/nat.2012.0352","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T20:58:04Z","timestamp":1777669084000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1089\/nat.2012.0352"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,9,10]]},"references-count":14,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2012,10,1]]}},"alternative-id":["10.1089\/nat.2012.0352"],"URL":"https:\/\/doi.org\/10.1089\/nat.2012.0352","relation":{},"ISSN":["2159-3337","2159-3345"],"issn-type":[{"value":"2159-3337","type":"print"},{"value":"2159-3345","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,9,10]]}}}