{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T19:42:39Z","timestamp":1777923759561,"version":"3.51.4"},"reference-count":19,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2015,12,1]],"date-time":"2015-12-01T00:00:00Z","timestamp":1448928000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Nucleic Acid Therapeutics"],"published-print":{"date-parts":[[2015,12]]},"abstract":"<jats:p>\n                    Japanese cedar pollinosis is one of the most prevalent allergies in Japan. Reducing the allergen content of pollen plays a major role in the alleviation of allergy symptoms. Aptamers, oligonucleotides with an affinity for specific molecules, have great potential for reducing allergic activity. In this study, we report that the anti-Cry j 2 aptamers, CJ2-04 and CJ2-08, inhibited allergen\u2013antibody reactions between Cry j 2, one of the major allergens in Japanese cedar pollen, and immunoglobulin E in serum collected from a patient with Japanese cedar pollinosis. In addition, the suppression of Ca\n                    <jats:sup>2+<\/jats:sup>\n                    mobilization in basophils, which is related to degranulation, was observed in samples preincubated with either of these DNA aptamers. This study indicates that anti-Cry j 2 aptamers may inhibit allergen\u2013antibody reactions and suppress the induction of Japanese cedar pollinosis, possibly leading to a novel external defense against this and other types of allergens.\n                  <\/jats:p>","DOI":"10.1089\/nat.2015.0539","type":"journal-article","created":{"date-parts":[[2015,10,20]],"date-time":"2015-10-20T16:34:34Z","timestamp":1445358874000},"page":"311-316","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Inhibition of an Allergen\u2013Antibody Reaction Related to Japanese Cedar Pollinosis Using DNA Aptamers Against the Cry j 2 Allergen"],"prefix":"10.1177","volume":"25","author":[{"given":"Kazumasa","family":"Ogihara","sequence":"first","affiliation":[{"name":"Tokyo University of Agriculture and Technology","place":["Japan"]},{"name":"DHC Corporation","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nasa","family":"Savory","sequence":"additional","affiliation":[{"name":"Tokyo University of Agriculture and Technology","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koichi","family":"Abe","sequence":"additional","affiliation":[{"name":"Tokyo University of Agriculture and Technology","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wataru","family":"Yoshida","sequence":"additional","affiliation":[{"name":"Tokyo University of Technology","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mitsuru","family":"Arakawa","sequence":"additional","affiliation":[{"name":"DHC Corporation","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masahiko","family":"Asahi","sequence":"additional","affiliation":[{"name":"DHC Corporation","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seika","family":"Kamohara","sequence":"additional","affiliation":[{"name":"DHC Corporation","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazunori","family":"Ikebukuro","sequence":"additional","affiliation":[{"name":"Tokyo University of Agriculture and Technology","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2015,12]]},"reference":[{"key":"e_1_3_3_2_2","first-page":"2001","article-title":"Nationwide epidemiological study allergic rhinitis","volume":"28","author":"Baba K","year":"2008","unstructured":"Baba K, and Nakae K. 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