{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T22:33:21Z","timestamp":1783031601189,"version":"3.54.6"},"reference-count":25,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Nucleic Acid Therapeutics"],"published-print":{"date-parts":[[2021,12,1]]},"abstract":"<jats:p>\n                    Ribosomal protein L3-like (RPL3L) is a poorly characterized ribosomal protein that is exclusively expressed in skeletal and cardiac muscle. RPL3L is also downregulated in Duchenne muscular dystrophy (DMD), suggesting that it may play an important role in muscle biology. In this study, we investigated the role of RPL3L in skeletal muscle of healthy C57 and dystrophic\n                    <jats:italic toggle=\"yes\">mdx<\/jats:italic>\n                    mice. We show that RPL3L is developmentally regulated and that intramuscular adeno-associated virus (AAV)-mediated RPL3L knockdown in the tibialis anterior of C57 and\n                    <jats:italic toggle=\"yes\">mdx<\/jats:italic>\n                    mice results in increased specific force with improved resistance to eccentric contraction induced muscle damage in dystrophic muscles. The mechanism by which RPL3L knockdown improves muscle function remains unclear. Histological observations showed a significant increase in muscle length and decrease in muscle cross-sectional area after RPL3L inhibition suggesting that this ribosomal protein may play a role in myofiber morphology. The endogenous downregulation of RPL3L in DMD may be a protective mechanism that attempts to improve skeletal muscle function and counteract the dystrophic phenotype.\n                  <\/jats:p>","DOI":"10.1089\/nat.2020.0928","type":"journal-article","created":{"date-parts":[[2021,6,3]],"date-time":"2021-06-03T15:07:10Z","timestamp":1622732830000},"page":"457-464","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":19,"title":["Knockdown of Muscle-Specific Ribosomal Protein L3-Like Enhances Muscle Function in Healthy and Dystrophic Mice"],"prefix":"10.1177","volume":"31","author":[{"given":"Betty R.","family":"Kao","sequence":"first","affiliation":[{"name":"Department of Biological Sciences, School of Life Sciences and the Environment, Royal Holloway University of London, Egham, United Kingdom."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0536-5231","authenticated-orcid":false,"given":"Alberto","family":"Malerba","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, School of Life Sciences and the Environment, Royal Holloway University of London, Egham, United Kingdom."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7241-9607","authenticated-orcid":false,"given":"Ngoc B.","family":"Lu-Nguyen","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, School of Life Sciences and the Environment, Royal Holloway University of London, Egham, United Kingdom."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pradeep","family":"Harish","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, School of Life Sciences and the Environment, Royal Holloway University of London, Egham, United Kingdom."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John J.","family":"Mccarthy","sequence":"additional","affiliation":[{"name":"Department of Physiology, University of Kentucky, Lexington, Kentucky, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Dickson","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, School of Life Sciences and the Environment, Royal Holloway University of London, Egham, United Kingdom."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda J.","family":"Popplewell","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, School of Life Sciences and the Environment, Royal Holloway University of London, Egham, United Kingdom."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2021,12,10]]},"reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.1006\/geno.1996.0538"},{"key":"e_1_3_5_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1982.tb01216.x"},{"key":"e_1_3_5_4_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.genet.33.1.261"},{"key":"e_1_3_5_5_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0001854"},{"key":"e_1_3_5_6_2","doi-asserted-by":"publisher","DOI":"10.1261\/rna.043653.113"},{"key":"e_1_3_5_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00439-020-02188-6"},{"key":"e_1_3_5_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.25294"},{"key":"e_1_3_5_9_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.151.6.1321"},{"key":"e_1_3_5_10_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.192571199"},{"key":"e_1_3_5_11_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2164-11-345"},{"key":"e_1_3_5_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/mus.23810"},{"key":"e_1_3_5_13_2","doi-asserted-by":"publisher","DOI":"10.1155\/2011\/210797"},{"key":"e_1_3_5_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/0960-8966(93)90110-6"},{"key":"e_1_3_5_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymthe.2018.07.011"},{"key":"e_1_3_5_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms14848"},{"key":"e_1_3_5_17_2","first-page":"3091","article-title":"Functional muscle recovery following dystrophin and myostatin exon splice modulation in aged mdx mice","volume":"28","author":"Lu-Nguyen N","year":"2019","unstructured":"Lu-Nguyen N, , Ferry A, , Schnell FJ, , Hanson GJ, , Popplewell L, , Dickson G, and Malerba A. (2019). Functional muscle recovery following dystrophin and myostatin exon splice modulation in aged mdx mice. 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