{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T19:46:06Z","timestamp":1777923966271,"version":"3.51.4"},"reference-count":41,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Nucleic Acid Therapeutics"],"published-print":{"date-parts":[[2021,12,1]]},"abstract":"<jats:p>\n                    Newly emerged highly pathogenic A\/H7N9 viruses with pandemic potential are effectively transmitted from birds to humans and require the development of novel antiviral drugs. For the first time, we studied the\n                    <jats:italic toggle=\"yes\">in vitro<\/jats:italic>\n                    and\n                    <jats:italic toggle=\"yes\">in vivo<\/jats:italic>\n                    antiviral activity against A\/H7N9 of oligodeoxyribonucleotides (ODNs), which were delivered into the cells in the proposed TiO\n                    <jats:sub>2<\/jats:sub>\n                    -based nanocomposites (TiO\n                    <jats:sub>2<\/jats:sub>\n                    \u223cODN). The highest inhibition of A\/H7N9\n                    <jats:italic toggle=\"yes\">in vitro<\/jats:italic>\n                    (\u223c400-fold) and efficient, sequence-specific, and dose-dependent protection (up to 100%) of A\/H7N9-infected mice was revealed when ODN was targeted to the conserved terminal 3\u2032-noncoding region of viral (\u2212)RNA. After the treatment with ODN, the virus titer values in the lungs of mice decreased by several orders of magnitude. The TiO\n                    <jats:sub>2<\/jats:sub>\n                    \u223cODN nanocomposite did not show toxicity in mice under the treatment conditions. The proposed approach for effective inhibition of the A\/H7N9 can be tested against other viruses, for example, new emerging influenza viruses and coronaviruses with pandemic potential.\n                  <\/jats:p>","DOI":"10.1089\/nat.2021.0061","type":"journal-article","created":{"date-parts":[[2021,10,19]],"date-time":"2021-10-19T12:35:16Z","timestamp":1634646916000},"page":"436-442","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["Effective Inhibition of Newly Emerged A\/H7N9 Virus with Oligonucleotides Targeted to Conserved Regions of the Virus Genome"],"prefix":"10.1177","volume":"31","author":[{"given":"Marina","family":"Repkova","sequence":"first","affiliation":[{"name":"Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of Russian Academy of Sciences, Novosibirsk, Russia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Asya","family":"Levina","sequence":"additional","affiliation":[{"name":"Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of Russian Academy of Sciences, Novosibirsk, Russia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zinfer","family":"Ismagilov","sequence":"additional","affiliation":[{"name":"Institute of Catalysis, Siberian Branch of Russian Academy of Sciences, Novosibirsk, Russia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natalia","family":"Mazurkova","sequence":"additional","affiliation":[{"name":"FBRI State Research Center of Virology and Biotechnology \u201cVector\u201d, Novosibirsk, Russia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oleg","family":"Mazurkov","sequence":"additional","affiliation":[{"name":"FBRI State Research Center of Virology and Biotechnology \u201cVector\u201d, Novosibirsk, Russia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valentina","family":"Zarytova","sequence":"additional","affiliation":[{"name":"Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of Russian Academy of Sciences, Novosibirsk, Russia."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2021,12,10]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1304459"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid2308.170640"},{"key":"e_1_3_4_4_2","volume-title":"et al","author":"Ke C","unstructured":"Ke C, , Mok CKP, , Zhu W, , Zhou H, , He J, , Guan W, , Wu J, , Song W, , Wang D, et al. 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