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Motor function in WT and Bax null mice was evaluated using the round beam balance and the wire grip test on days 0\u20135. Spatial memory was assessed using a Morris Water Maze adopted for mice on days 14\u201318 post-injury. For histopathological analysis, animals were sacrificed 24\u2009h and 21 days post-injury. In all three behavioral tests, the sham and TBI-injured Bax null mice performed significantly worse than their WT sham and TBI-injured counterparts. However, Bax null mice exhibited a higher percentage of surviving neurons in the CA1 and CA3 regions of hippocampus measured at 21 days post-injury. At 24\u2009h after trauma, Bax null mice had fewer TUNEL positive cells in the CA1 and dentate regions of hippocampus as compared to WT mice, suggesting that deletion of the Bax gene ameliorates hippocampal cell death after TBI. Sham-operated Bax null mice had significantly greater brain volume as compared to WT mice. Thus, it is possible that Bax deficiency in the transgenic mice produces developmental behavioral effects, perhaps due to Bax's role in regulating cell death during development.<\/jats:p>","DOI":"10.1089\/neu.2007.0441","type":"journal-article","created":{"date-parts":[[2008,7,16]],"date-time":"2008-07-16T03:34:36Z","timestamp":1216179276000},"page":"755-767","source":"Crossref","is-referenced-by-count":54,"title":["Disruption of Bax Protein Prevents Neuronal Cell Death but Produces Cognitive Impairment in Mice following Traumatic Brain Injury"],"prefix":"10.1177","volume":"25","author":[{"given":"Roya","family":"Tehranian","sequence":"first","affiliation":[{"name":"Veterans Administration Pittsburgh Healthcare System"},{"name":"University of Pittsburgh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie E.","family":"Rose","sequence":"additional","affiliation":[{"name":"Veterans Administration Pittsburgh Healthcare System"},{"name":"University of Pittsburgh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"Vagni","sequence":"additional","affiliation":[{"name":"University of Pittsburgh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alicia M.","family":"Pickrell","sequence":"additional","affiliation":[{"name":"Veterans Administration Pittsburgh Healthcare System"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raymond P.","family":"Griffith","sequence":"additional","affiliation":[{"name":"University of Pittsburgh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Liu","sequence":"additional","affiliation":[{"name":"Veterans Administration Pittsburgh Healthcare System"},{"name":"University of Pittsburgh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert S.B.","family":"Clark","sequence":"additional","affiliation":[{"name":"University of Pittsburgh"},{"name":"University of Pittsburgh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. 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