{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T19:47:48Z","timestamp":1777924068630,"version":"3.51.4"},"reference-count":0,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2009,1,1]],"date-time":"2009-01-01T00:00:00Z","timestamp":1230768000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Neurotrauma"],"published-print":{"date-parts":[[2009,1]]},"abstract":"<jats:p>\n                    In the present study, we transplanted E13.5 spinal cord\u2013derived neural progenitor cells (NPCs) into the acutely avulsed ventral horn of adult rats. The results showed that NPCs survived and integrated nicely within the host ventral horn at 6 weeks post-grafting. Although the majority of grafted NPCs differentiated into astrocytes and only a small proportion into neuronal cells, interestingly, grafted NPCs in the avulsed ventral horn significantly enhanced the survival of injured motoneurons and promoted their regeneration into a peripheral nerve (PN) graft, as revealed by retrograde FluoroGold (FG) labeling. Specific ELISAs, Western blotting, and quantitative real-time reverse transcriptase polymerase chain reaction (RT-PCR) demonstrated that NPCs produced nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), and glial cell line\u2013derived neutrophilic factor (GDNF), both\n                    <jats:italic toggle=\"yes\">in vitro<\/jats:italic>\n                    and after transplantation\n                    <jats:italic toggle=\"yes\">in vivo<\/jats:italic>\n                    . These results indicate that NPCs have beneficial effects on the survival and axonal regeneration of avulsion-injured motoneurons after transplantation. Such beneficial effects are possibly due to their inherent ability to secrete various trophic factors after transplantation\n                    <jats:italic toggle=\"yes\">in vivo.<\/jats:italic>\n                  <\/jats:p>","DOI":"10.1089\/neu.2008.0656","type":"journal-article","created":{"date-parts":[[2009,2,6]],"date-time":"2009-02-06T23:31:30Z","timestamp":1233963090000},"page":"67-80","source":"Crossref","is-referenced-by-count":31,"title":["Neural Progenitor Cells Enhance the Survival and Axonal Regeneration of Injured Motoneurons after Transplantation into the Avulsed Ventral Horn of Adult Rats"],"prefix":"10.1177","volume":"26","author":[{"given":"Huanxing","family":"Su","sequence":"first","affiliation":[{"name":"The University of Hong Kong","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenming","family":"Zhang","sequence":"additional","affiliation":[{"name":"The University of Hong Kong","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiasong","family":"Guo","sequence":"additional","affiliation":[{"name":"The University of Hong Kong","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anchen","family":"Guo","sequence":"additional","affiliation":[{"name":"The University of Hong Kong","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiuju","family":"Yuan","sequence":"additional","affiliation":[{"name":"The University of Hong Kong","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wutian","family":"Wu","sequence":"additional","affiliation":[{"name":"The University of Hong Kong","place":["China"]},{"name":"The University of Hong Kong","place":["China"]},{"name":"The University of Hong Kong","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2009,1,1]]},"container-title":["Journal of Neurotrauma"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/neu.2008.0656","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/neu.2008.0656","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T21:10:52Z","timestamp":1777669852000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1089\/neu.2008.0656"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,1]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2009,1]]}},"alternative-id":["10.1089\/neu.2008.0656"],"URL":"https:\/\/doi.org\/10.1089\/neu.2008.0656","relation":{},"ISSN":["0897-7151","1557-9042"],"issn-type":[{"value":"0897-7151","type":"print"},{"value":"1557-9042","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,1]]}}}