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It is suspected that neurometabolic changes may underlie these changes. In this study we investigated the effects of sports concussion on brain metabolism using\n                    <jats:sup>1<\/jats:sup>\n                    H-MR spectroscopy by comparing a group of 12 non-concussed athletes with a group of 12 concussed athletes of the same age (mean 22.5 years) and education (mean 16 years). All athletes were scanned 1\u20136 days post-concussion in a 3T Siemens MRI, and were administered a symptom scale to evaluate post-concussion symptomatology. Participants also completed a neuropsychological test battery to assess verbal memory, visual memory, information processing speed, and reaction time, and no group differences were detected relative to controls. Concussed athletes showed a higher number of symptoms than non-concussed athletes, and they also showed a significant decrease in glutamate in the primary motor cortex (M1), as well as significant decreases in\n                    <jats:italic toggle=\"yes\">N<\/jats:italic>\n                    -acetylaspartate in the prefrontal and primary motor cortices. No changes were observed in the hippocampus. Furthermore, the metabolic changes in M1 correlated with self-reported symptom severity despite equivalent neuropsychological performance. These results confirm cortical neurometabolic changes in the acute post-concussion phase, and demonstrate for the first time a correlation between subjective self-reported symptoms and objective physical changes that may be related to increased vulnerability of the concussed brain.\n                  <\/jats:p>","DOI":"10.1089\/neu.2009.0962","type":"journal-article","created":{"date-parts":[[2009,9,17]],"date-time":"2009-09-17T11:37:52Z","timestamp":1253187472000},"page":"65-76","source":"Crossref","is-referenced-by-count":165,"title":["Neurometabolic Changes in the Acute Phase after Sports Concussions Correlate with Symptom Severity"],"prefix":"10.1177","volume":"27","author":[{"given":"Luke C.","family":"Henry","sequence":"first","affiliation":[{"name":"University of Montr\u00e9al","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00e9bastien","family":"Tremblay","sequence":"additional","affiliation":[{"name":"University of Montr\u00e9al","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yvan","family":"Boulanger","sequence":"additional","affiliation":[{"name":"University of Montr\u00e9al and H\u00f4pital Saint-Luc","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dave","family":"Ellemberg","sequence":"additional","affiliation":[{"name":"University of Montr\u00e9al","place":["Canada"]},{"name":"University of Montr\u00e9al","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maryse","family":"Lassonde","sequence":"additional","affiliation":[{"name":"University of Montr\u00e9al","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2010,1,1]]},"reference":[{"key":"e_1_3_3_2_1","first-page":"5","article-title":"SPECT brain perfusion findings in mild or moderate traumatic brain injury","volume":"3","author":"Abu-Judeh H.H.","year":"2000","unstructured":"Abu-Judeh H.H., , Parker R., , Aleksic S., , Singh M.L., , Naddaf S., , Atay S., , Kumar M., , Omar W., , El-Zeftawy H., , Luo J.Q., , Abdel-Dayem H.M. 2000. 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