{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T13:44:07Z","timestamp":1782913447540,"version":"3.54.5"},"reference-count":45,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2010,4,1]],"date-time":"2010-04-01T00:00:00Z","timestamp":1270080000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Neurotrauma"],"published-print":{"date-parts":[[2010,4]]},"abstract":"<jats:p>\n                    In this study we tested the hypothesis that hyperbaric oxygen preconditioning (HBO-PC) reduces retinal neuronal death due to optic nerve crush (ONC). Adult male Sprague-Dawley rats were subjected to ONC accompanied by a contralateral sham operation. HBO-PC was conducted four times by giving 100% oxygen at 2.5 atmospheres absolute (ATA) for 1\u2009h every 12\u2009h for 2 days prior to ONC. The rats were euthanized at 1 or 2 weeks after ONC. Retinal ganglion cell (RGC) density was counted by hematoxylin and eosin (H&amp;E) staining of the retina and retrograde labeling with FluoroGold application to the superior colliculus. Visual function was assessed by flash visual evoked potentials (FVEP). TUNEL straining and caspase-3 and caspase-9 activity in the retinas were assessed. The RGC density in the retinas of ONC HBO-PC-treated rats was significantly higher than that of the corresponding ONC-only rats (the survival rate was 67.2% versus 49.7% by H&amp;E staining, and 60.3% versus 28.9% by retrograde labeling with FluoroGold, respectively;\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009&lt;\u20090.01) at 2 weeks after ONC. FVEP measurements indicated a significantly better preserved latency and amplitude of the P1 wave in the ONC HBO-PC-treated rats than the ONC-only rats (92\u2009\u00b1\u20097\u2009msec, 21\u2009\u00b1\u20093\u2009\u03bcv in the sham-operated group, 117\u2009\u00b1\u200912\u2009msec, 14\u2009\u00b1\u20092\u2009\u03bcv in the HBO-PC-treated group, and 169\u2009\u00b1\u200915\u2009msec, 7\u2009\u00b1\u20091\u2009\u03bcv in the corresponding ONC group;\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009&lt;\u20090.01). TUNEL assays showed fewer apoptotic cells in the HBO-PC-treated group, accompanied by the suppression of caspase-3 and caspase-9 activity. These results demonstrate that HBO-PC appears to be neuroprotective against ONC insult via inhibition of neuronal apoptosis pathways.\n                  <\/jats:p>","DOI":"10.1089\/neu.2009.1005","type":"journal-article","created":{"date-parts":[[2010,1,13]],"date-time":"2010-01-13T10:37:33Z","timestamp":1263379053000},"page":"763-770","source":"Crossref","is-referenced-by-count":26,"title":["Hyperbaric Oxygen Preconditioning Promotes Survival of Retinal Ganglion Cells in a Rat Model of Optic Nerve Crush"],"prefix":"10.1177","volume":"27","author":[{"given":"Ruobing","family":"Wang","sequence":"first","affiliation":[{"name":"Changhai Hospital","place":["China"]},{"name":"Second Military Medical University","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiajun","family":"Xu","sequence":"additional","affiliation":[{"name":"Second Military Medical University","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaxin","family":"Xie","sequence":"additional","affiliation":[{"name":"Second Military Medical University","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhimin","family":"Kang","sequence":"additional","affiliation":[{"name":"Second Military Medical University","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuejun","family":"Sun","sequence":"additional","affiliation":[{"name":"Second Military Medical University","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na","family":"Chen","sequence":"additional","affiliation":[{"name":"Changhai Hospital","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Liu","sequence":"additional","affiliation":[{"name":"Changhai Hospital","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiajun","family":"Xu","sequence":"additional","affiliation":[{"name":"Second Military Medical University","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2010,4]]},"reference":[{"key":"e_1_3_3_2_1","doi-asserted-by":"publisher","DOI":"10.1089\/neu.1999.16.153"},{"key":"e_1_3_3_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0169-328X(99)00032-7"},{"key":"e_1_3_3_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004647-200205000-00001"},{"key":"e_1_3_3_5_1","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1397.027"},{"key":"e_1_3_3_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3940(01)02418-1"},{"key":"e_1_3_3_7_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1460-9568.2002.01977.x"},{"key":"e_1_3_3_8_1","first-page":"15","article-title":"Proteasome inhibitors eliminate protective effect of postconditioning in cultured neonatal cardiomyocytes","volume":"52","author":"Dosenko V.E.","year":"2006","unstructured":"Dosenko V.E., , Nagibin V.S., , Tumanovskaya L.V., , Zagoriy V.Y., , Moibenko A.A., , Vaage J. 2006. 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