{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T06:07:21Z","timestamp":1792735641595,"version":"4.5.0"},"reference-count":62,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Neurotrauma"],"published-print":{"date-parts":[[2010,1]]},"abstract":"<jats:p>\n                    There is emerging evidence to suggest that brain natriuretic peptide (BNP) is elevated after acute brain injury, and that it may play an adaptive role in recovery through augmentation of cerebral blood flow (CBF). Through a series of experiments, we tested the hypothesis that the administration of BNP after different acute mechanisms of central nervous system (CNS) injury could improve functional recovery by improving CBF. C57 wild-type mice were exposed to either pneumatic-induced closed traumatic brain injury (TBI) or collagenase-induced intracerebral hemorrhage (ICH). After injury, either nesiritide (hBNP) (8\u2009\u03bcg\/kg) or normal saline were administered via tail vein injection at 30\u2009min and 4\u2009h. The mice then underwent functional neurological testing via rotorod latency over the following 5 days and neurocognitive testing via Morris water maze testing on days 24\u201328. Cerebral blood flow (CBF) was assessed by laser Doppler from 25 to 90\u2009min after injury. After ICH, mRNA polymerase chain reaction (PCR) and histochemical staining were performed during the acute injury phase (&lt;24\u2009h) to determine the effects on inflammation. Following TBI and ICH, administration of hBNP was associated with improved functional performance as assessed by rotorod and Morris water maze latencies (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009&lt;\u20090.01). CBF was increased (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009&lt;\u20090.05), and inflammatory markers (TNF-\u03b1 and IL-6;\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009&lt;\u20090.05), activated microglial (F4\/80;\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009&lt;\u20090.05), and neuronal degeneration (Fluoro-Jade B;\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009&lt;\u20090.05) were reduced in mice receiving hBNP. hBNP improves neurological function in murine models of TBI and ICH, and was associated with enhanced CBF and downregulation of neuroinflammatory responses. hBNP may represent a novel therapeutic strategy after acute CNS injury.\n                  <\/jats:p>","DOI":"10.1089\/neu.2009.1022","type":"journal-article","created":{"date-parts":[[2009,10,5]],"date-time":"2009-10-05T13:58:06Z","timestamp":1254751086000},"page":"217-228","source":"Crossref","is-referenced-by-count":50,"title":["Brain Natriuretic Peptide Improves Long-Term Functional Recovery after Acute CNS Injury in Mice"],"prefix":"10.1177","volume":"27","author":[{"given":"Michael L.","family":"James","sequence":"first","affiliation":[{"name":"Duke University Medical Center"},{"name":"Duke University Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haichen","family":"Wang","sequence":"additional","affiliation":[{"name":"Duke University Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Talaignair","family":"Venkatraman","sequence":"additional","affiliation":[{"name":"Duke University Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pingping","family":"Song","sequence":"additional","affiliation":[{"name":"Duke University Medical Center"},{"name":"Duke University Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher D.","family":"Lascola","sequence":"additional","affiliation":[{"name":"Duke University Medical Center"},{"name":"Duke University Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel T.","family":"Laskowitz","sequence":"additional","affiliation":[{"name":"Duke University Medical Center"},{"name":"Duke University Medical Center"},{"name":"Duke University Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2010,1,1]]},"reference":[{"key":"e_1_3_3_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.33.1.290"},{"key":"e_1_3_3_3_1","doi-asserted-by":"publisher","DOI":"10.1067\/mhj.2002.125620"},{"key":"e_1_3_3_4_1","doi-asserted-by":"publisher","DOI":"10.1042\/cs0880159"},{"key":"e_1_3_3_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2007.04.018"},{"key":"e_1_3_3_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00234-008-0402-x"},{"key":"e_1_3_3_7_1","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1994.80.2.0301"},{"key":"e_1_3_3_8_1","doi-asserted-by":"publisher","DOI":"10.1089\/neu.1994.11.187"},{"key":"e_1_3_3_9_1","doi-asserted-by":"publisher","DOI":"10.1089\/089771503770195849"},{"key":"e_1_3_3_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-4328(98)00134-X"},{"key":"e_1_3_3_11_1","doi-asserted-by":"publisher","DOI":"10.3317\/jraas.2001.024"},{"key":"e_1_3_3_12_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000027274.03779.F3"},{"key":"e_1_3_3_13_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.108.530402"},{"key":"e_1_3_3_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12028-007-9030-2"},{"key":"e_1_3_3_15_1","doi-asserted-by":"publisher","DOI":"10.1159\/000094997"},{"key":"e_1_3_3_16_1","first-page":"1108","article-title":"Effects of intravenous atrial natriuretic peptide on cardiac sympathetic nerve activity in patients with decompensated congestive heart failure","volume":"45","author":"Kasama S.","year":"2004","unstructured":"Kasama S., , Toyama T., , Kumakura H., , Takayama Y., , Ishikawa T., , Ichikawa S., , Suzuki T., , Kurabayashi M. 2004. 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